The herb of Panax notoginseng was fermented by three Paecilomyces fungi(Paecilomyces hepiali,Paecilomyces militaris and Paecilomyces cicadae),and the changes of useful components in the fermentation products were detected.The results showed that the strains of Paecilomyces hepiali and Paecilomyces militaris could transform ginsenoside Rb1 into ginsenoside Rd.The fermentation products achieved high yield of rare ginsenoside Rd,and contained adenosine,cordycepin and mannito.This study indicated that abundant and new medicinal resources could be got by the interaction between medicinal microbes and herbal medicines.