以纯度和晶体平均粒径为关键指标,研究了L-鸟氨酸-阿司匹林复合盐(L-ornithine-aspirin compound salt,以下简称"LOA")溶析结晶操作策略,如晶种加入策略、溶析剂加入量及流加速率等。根据LOA在乙醇/水二元溶剂体系中的溶解度曲线,将其结晶过程分成了5个阶段。结果表明,乙醇和LOA溶液的体积比为0.8时加入4%的晶种以及第III阶段适当降低乙醇流加速率有利于晶体生长。得到的产品纯度为97.9%,平均粒径为270.6μm。

Using purity,yield and average particle diameter of LOA as key indicators,various strategies of solventing-out crystallization of LOA,such as crystal seed addition,feeding rate and volume of antisolvent were studied.The process of the crystallization of LOA was divided into five stages based on the solubility curve of LOA in the ethanol / water system.The results showed that the crystalline growth was improved if 4% crystal seeds were added when the volume ratio of ethanol to LOA solution was 0.8 and the adding rate of ethanol in stage Ⅲ appropriately slowed down.The crystallization purity was 97.9%,and the average particle diameter was 270.6μm.