一株高产胞外多糖的嗜热链球菌MN-002,筛选自传统发酵乳品。为进一步探究嗜热链球菌MN-002对机体疲劳的缓解功效,采用108只雄性小鼠随机分为3组,分别灌胃生理盐水、MN-002发酵乳和MN-002菌粉45 d。通过小鼠负重游泳实验并检测血乳酸、血清尿素和肝糖原指标,对嗜热链球菌MN-002的抗疲劳功效进行分析。结果表明,MN-002发酵乳和菌粉均显著提升了小鼠的运动耐力,增加了肝脏中肝糖元储备量,降低了血乳酸和血清尿素氮含量。结果表明,嗜热链球菌MN-002发酵乳和菌粉均有缓解体力疲劳的功效,活菌数有效剂量均为2×108 CFU/d,为嗜热链球菌MN-002在抗疲劳方面的应用以及产品开发提供了理论依据。
A strain with high production of extracellular polysaccharides,Streptococcus thermophilus MN-002,was selected from traditional fermented dairy products.To further explore the efficacy of S.thermophilus MN-002 in relieving body fatigue,108 male mice were randomly divided into three groups,and were administered by saline,MN-002 fermented milk and MN-002 powder for 45 d.The anti-fatigue effect of S.thermophilus MN-002 was analyzed through the weight-bearing swimming test of mice and the detection of blood lactic acid,serum urea and liver glycogen indexes.The results showed that both fermented milk and bacterial powder significantly improved the exercise tolerance of mice,increased hepatic glycogen,and reduced blood lactate content and serum urea nitrogen.Therefore,it was concluded that MN-002 fermented milk and powder had the effect of relieving physical fatigue,and the effective dose was 2×108CFU/d.This provides a theoretical basis for the application of S.thermophilus MN-002 in anti-fatigue and product development.
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