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石斛多糖改善糖尿病作用的影响因素及机制研究进展

  • 方静宇 ,
  • 谢华凌 ,
  • 冯思敏 ,
  • 李振皓 ,
  • 李明焱 ,
  • 徐靖 ,
  • 邵平
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  • 1(浙江工业大学 食品科学与工程学院,浙江 杭州,310014)
    2(浙江寿仙谷医药股份有限公司,浙江 金华,321200)
硕士研究生(邵平教授为通讯作者,E-mail:pingshao325@zjut.edu.cn)

收稿日期: 2020-05-13

  修回日期: 2020-07-18

  网络出版日期: 2021-03-08

基金资助

浙江省科技厅重点研发项目(2019C02070;2018C02012)

Research progress on the influencing factors and mechanism of Dendrobium polysaccharide in ameliorating diabetic symptoms

  • FANG Jingyu ,
  • XIE Hualing ,
  • FENG Simin ,
  • LI Zhenhao ,
  • LI Mingyan ,
  • XU Jing ,
  • SHAO Ping
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  • 1(College of Food Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China)
    2(Zhejiang Shouxiangu Pharmaceutical Co.Ltd., Jinhua 321200, China)

Received date: 2020-05-13

  Revised date: 2020-07-18

  Online published: 2021-03-08

摘要

石斛属植物是目前广泛应用的补品和珍贵食品,它含有多糖、生物碱、氨基酸和微量元素等多种活性成分。近年来,随着代谢相关疾病的高发,石斛在防治糖尿病中的作用逐渐被挖掘。现代药理学研究证实,石斛多糖作为石斛中的主要活性成分,具有显著的降血糖效果,同时可以改善糖尿病的并发症,有被开发为保健食品、药品的潜力。针对此现状,该文阐述了石斛多糖在糖尿病中的药理作用(降血糖、防治糖尿病并发症),总结了影响石斛多糖药理活性的因素,并归纳了其主要作用机制的研究进展,为石斛多糖在防治糖尿病方面的研究及应用提供参考。

本文引用格式

方静宇 , 谢华凌 , 冯思敏 , 李振皓 , 李明焱 , 徐靖 , 邵平 . 石斛多糖改善糖尿病作用的影响因素及机制研究进展[J]. 食品与发酵工业, 2021 , 47(3) : 237 -244 . DOI: 10.13995/j.cnki.11-1802/ts.024475

Abstract

Dendrobium is currently been widely used in supplements and precious foods. It contains a variety of bioactive ingredients such as polysaccharides, alkaloids, amino acids and trace elements. Due to the high incidence of metabolic-related diseases, the bioactivities of Dendrobium in the prevention and treatment of diabetes have been gradually tapped, and also received more and more attention. Modern pharmacological studies have confirmed that Dendrobium polysaccharide, as the main bioactive ingredient in Dendrobium, had a significant effect on lowering blood sugar, and could improve the complications of diabetes. And thus had the potential to be developed as a health food and medicine. This article described the pharmacological effects of Dendrobium polysaccharides in diabetes (lowering blood sugar, preventing and treating diabetes complications) and summarized the factors and main mechanisms about the pharmacological activity of Dendrobium polysaccharides. So it provides guide for the research and application in the prevention and treatment of diabetes.

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