[1] 徐任生.天然产物化学[M].第二版.北京:科学出版社,2004.
XU R S.Chemistry of natural product[M].2nd ed.Beijing:Science Press,2004.
[2] 杨梦莉,赖泳红,郭凤根,等.灯盏花内生真菌分离及其产黄酮内生真菌的初步研究[J].西南农业学报,2018,31(2):318-321.
YANG M L,LAI Y H,GUO F G,et al.Isolation and selection of flavones-forming endophytic fungi from Erigeron breviscapus[J].Southwest China Journal of Agricultural Sciences,2018,31(2):318-321.
[3] XIAO Y,HAN F,LEE I S.Microbial transformation of licochalcones[J].Molecules,2020,25(1):60.
[4] MUKHERJEE A,MISHRA S,KOTLA N K,et al.Semisynthetic quercetin derivatives with potent antitumor activity in colon carcinoma[J].Acs Omega,2019,4(4):7 285-7 298.
[5] LI Y,LI Y,HE J,et al.The relationship between pharmacological properties and structure-activity of chrysin derivatives[J].Mini Reviews in Medicinal Chemistry,2019,19(7):555-568.
[6] 金永生,刘超美,吴秋业,等.新型金雀异黄素衍生物 5-羟基-4'-硝基-7-取代酰氧基异黄酮的合成及抗肿瘤活性研究[J].第二军医大学学报,2005,26(2):182-185.
JIN Y S,LIU C M,WU Q Y,et al.Design and synthesis of genistein derivatives 5-hydroxy-4'-nitro-7-substituted-acyloxo-isoflavone and their antitumor effects[J].Academic Journal of Second Military Medical University,2005,26(2):182-185.
[7] 刘建中,翁玲玲,郑虎.异黄酮哌嗪衍生物的合成[J].中国药物化学杂志,2000(1):49-51;56.
LIU J Z,WENG L L,ZHENG H.Synthesis of isoflavone piperazine derivatives[J].Chinese Journal of Medicinal Chemistry,2000(1):49-51;56.
[8] 邹丽秋,王彩霞,匡雪君,等.合成途径及合成生物学研究进展[J].中国中药杂志.2016.41(22):4 124-4 128.
ZOU L Q,WANG C X,KUANG X J,et al.Advance in flavonoids biosynthetic pathway and synthetic biology[J].China Journal of Chinese Materia Medica,2016,41(22):4 124-4 128.
[9] NABAVI S M,AMEC D,TOMCZYK M,et al.Flavonoid biosynthetic pathways in plants:Versatile targets for metabolic engineering[J].Biotechnology Advances,2020,38:107 316.
[10] PANDEY R P,PARAJULI P,KOFFAS M A G,et al.Microbial production of natural and non-natural flavonoids:Pathway engineering,directed evolution and systems/synthetic biology[J].Biotechnology Advances,2016,34(5):634-662.
[11] TRANTAS E A,KOFFAS M A G,XU P,et al.When plants produce not enough or at all:Metabolic engineering of flavonoids in microbial hosts[J].Frontiers in Plant Science,2015,6:7.
[12] WANG X,LI Z,POLICARPIO L,et al.De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering[J].Applied Microbiology and Biotechnology,2020:104(11):1-13.
[13] RODRIGUEZ A,STRUCKO T,STAHLHUT S G,et al.Metabolic engineering of yeast for fermentative production of flavonoids[J].Bioresource Technology,2017,245:1 645-1 654.
[14] HWANG E I,KANEKO M,OHNISHI Y,et al.Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster[J].Applied and Environmental Microbiology,2003,69(5):2 699-2 706.
[15] KOOPMAN F,BEEKWILDER J,CRIMI B,et al.De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae[J].Microbial Cell Factories,2012,11(1):155.
[16] TRANTAS E,PANOPOULOS N,VERVERIDIS F.Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae[J].Metabolic Engineering,2009,11(6):355-366.
[17] LV Y,EDWARDS H,ZHOU J,et al.Combining 26s rDNA and the Cre-loxP system for iterative gene integration and efficient marker curation in Yarrowia lipolytica[J].ACS Synthetic Biology,2019,8(3):568-576.
[18] PARK S R,YOON J A,PAIK J H,et al.Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae[J].Journal of Biotechnology,2009,141(3-4):181-188.
[19] MIYAHISA I,KANEKO M,FUNA N,et al.Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster[J].Applied Microbiology and Biotechnology,2005,68(4):498-504.
[20] MIYAHISA I,FUNA N,OHNISHI Y,et al.Combinatorial biosynthesis of flavones and flavonols in Escherichia coli[J].Applied Microbiology and Biotechnology,2006,71(1):53-58.
[21] ZHU S,WU J,DU G,et al.Efficient synthesis of eriodictyol from L-tyrosine in Escherichia coli[J].Applied and Environmental Microbiology,2014,80(10):3 072-3 080.
[22] LIM C G,FOWLER Z L,HUELLER T,et al.High-yield resveratrol production in engineered Escherichia coli[J].Applied and Environmental Microbiology,2011,77(10):3 451-3 460.
[23] KIM M J,KIM B G,AHN J H.Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli[J].Applied Microbiology and Biotechnology,2013,97(16):7 195-7 204.
[24] WATTS K T,LEE P C,SCHMIDT-DANNERT C.Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli[J].BMC Biotechnology,2006,6(1):22.
[25] LU Y,YE C,CHE J,et al.Genomic sequencing,genome-scale metabolic network reconstruction,and in silico flux analysis of the grape endophytic fungus Alternaria sp.MG1[J].Microbial Cell Factories,2019,18(1):13.
[26] ISAKA M,JATURAPAT A,RUKSEREE K,et al.Phomoxanthones A and B,novel xanthone dimers from the endophytic fungus Phomopsis species[J].Journal of Natural Products,2001,64(8):1 015-1 018.
[27] TIAN X,HUANG C,HUANG J.Identification of flavonoids and flavonoid-producing endophytic fungi isolated from Opisthopappus taihangensis (Ling) C.Shih[J].Bangladesh Journal of Botany,2017,46(3):1 063-1 070.
[28] 周宁.甘蔗叶产黄酮内生真菌的筛选与鉴定[D].南宁:广西大学,2017.
ZHOU N.Screening and identification of flavonoids-producing endophytic fungi from sugarcane leaves[D].Nanning:Guangxi University,2017.
[29] XU J,KJER J,SENDKER J,et al.Chromones from the endophytic fungus Pestalotiopsis sp.isolated from the Chinese mangrove plant Rhizophora mucronata[J].Journal of Natural Products,2009,72(4):662-665.
[30] WAGENAAR M M,CLARDY J.Dicerandrols,new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint[J].Journal of Natural Products,2001,64(8):1 006-1 009.
[31] 张海龙,李善春,卢维浩,等.银杏内生真菌多样性与产黄酮类物质真菌的分离和鉴定[J].土壤,2015,47(1):135-141.
ZHANG H L,LI S C,LU W H,et al.Distribution and identification of flavonoid-producing endophytic Fungi in Ginkgo biloba L[J].Soils,2015,47(1):135-141.
[32] TANG Z,WANG Y,YANG J,et al.Isolation and identification of flavonoid-producing endophytic fungi from medicinal plant Conyza blinii H.Lév that exhibit higher antioxidant and antibacterial activities[J].PeerJ,2020,8:e8978.
[33] 柯树炜,吕金慧,陈萍,等.产黄酮番木瓜内生真菌的筛选和鉴定[J].生物技术通报,2019,35(3):47-52.
KE S W,LV J H,CHEN P,et al.Isolation and identification of flavonoids-producing endophytic fungi in papaya[J].Biotechnology Bulletin,2019,35(3):47-52.
[34] 李姝诺,李亚东,王琦,等.越橘产黄酮类化合物内生真菌的筛选[J].吉林农业大学学报,2009,31(5):587-591.
LI S N,LI Y D,WANG Q,et al.Bolting flavonoid-producing endophytic fungi from Vaccinium[J].Journal of Jilin Agricultural University,2009,31(5):587-591.
[35] WIJERATNE E M K,TURBYVILLE T J,FRITZ A,et al.A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity[J].Bioorganic & Medicinal Chemistry,2006,14(23):7 917-7 923.
[36] 王欢.瑞香狼毒内生真菌分离鉴定与发酵产物黄酮的检测[D].杨凌:西北农林科技大学,2016.
WANG H.Isolation and identification of fungal endophytes of Stellera chamaejasme L.and testing for flavonoids produced through fermentation[D].Yangling:Northwest A&F University,2016.
[37] 康帅涛,李晓东,许环军,等.黄酮及其衍生物的高效合成和抗肿瘤活性[J].沈阳药科大学学报,2011,28(11):862-867;881.
KANG S L,LI X D,XU H J,et al.Efficient synthesis and antitumor activities of flavone and its derivatives[J].Journal of Shenyang Pharmaceutical University,2011,28(11):862-867;881.
[38] 段新方,张站斌,段新红.5,3',4'-三羟基-6,7-二甲氧基黄酮的另法全合成[J].有机化学,2003(4):353-355.
DUAN X F,ZHANG Z B,DUAN X H.Modified Synthesis of 5,3',4'-trihydroxyl-6,7-dimethoxyflavone[J].Chinese Journal of Organic Chemistry,2003(4):353-355.
[39] CHAUDHARY A K,HWANG I Y,JO Y J,et al.Enzymatic synthesis of amentoflavone glycoside using recombinant oleandomycin glycosyltransferase[J].Journal of Industrial and Engineering Chemistry,2015,25:304-307.
[40] MKRTCHYAN S,IAROSHENKO V O.Visible-light-mediated arylation of ortho-hydroxyarylenaminones:Direct access to isoflavones[J].Chemical Communications,2020,56(17):2606-2609.
[41] GAO C,MAYON P,MACMANUS D A,et al.Novel enzymatic approach to the synthesis of flavonoid glycosides and their esters[J].Biotechnology and Bioengineering,2000,71(3):235-243.
[42] CHAUDHARY A K,HWANG I Y,JO Y J,et al.Enzymatic synthesis of amentoflavone glycoside using recombinant oleandomycin glycosyltransferase[J].Journal of Industrial and Engineering Chemistry,2015,25:304-307.
[43] DYMARSKA M,JANECZKO T,KOSTRZEWA-SUSOW E.Glycosylation of methoxylated flavonoids in the cultures of Isaria fumosorosea KCH J2[J].Molecules,2018,23(10):2 578.
[44] MANDALARI G,BENNETT R N,BISIGNANO G,et al.Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel,a byproduct of the essential oil industry[J].Journal of Applied Microbiology,2007,103(6):2 056-2 064.
[45] WEI Q K,CHEN T R,CHEN J T.Using of Lactobacillus and Bifidobacterium to product the isoflavone aglycones in fermented soymilk[J].International Journal of Food Microbiology,2007,117(1):120-124.
[46] GAYA P,PEIROTN ,LANDETE J M.Transformation of plant isoflavones into bioactive isoflavones by lactic acid bacteria and Bifidobacteria[J].Journal of Functional Foods,2017,39:198-205.
[47] GAYOT S,SANTARELLI X,COULON D.Modification of flavonoid using lipase in non-conventional media:Effect of the water content[J].Journal of Biotechnology,2003,101(1):29-36.
[48] ARAÚJO K C F,DE MB COSTA E M,PAZINI F,et al.Bioconversion of quercetin and rutin and the cytotoxicity activities of the transformed products[J].Food and Chemical Toxicology,2013,51:93-96.
[49] BUISSON D,QUINTIN J,LEWIN G.Biotransformation of polymethoxylated flavonoids:access to their 4'-O-demethylated metabolites[J].Journal of Natural Products,2007,70(6):1 035-1 038.
[50] KOSTRZEWA-SUSOW E,JANECZKO T.Microbial transformations of 5-hydroxy-and 5-methoxyflavone in Aspergillus niger and Penicillium chermesinum cultures[J].Journal of Microbiology,Biotechnology and Food Sciences,2018,3(6):448-452.
[51] DIAS T A,DUARTE C L,LIMA C F,et al.Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin[J].European Journal of Medicinal Chemistry,2013,65:500-510.
[52] COPMANS D,ORELLANA-PAUCAR A M,STEURS G,et al.Methylated flavonoids as anti-seizure agents:Naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models[J].Neurochemistry International,2018,112:124-133.
[53] 梅青刚,袁伟成,王淳.黄酮醇类化合物的合成研究进展[J].有机化学,2015,35(1):70-84.
MEI Q G,YUAN W C,WANG C.Progress in the synthesis of 3-hydroxyflavones[J].Chinese Journal of Organic Chemistry,2015,35(1):70-84.