综述与专题评论

异构酶在生物制造中的研究进展

  • 徐铮 ,
  • 徐恺 ,
  • 陈昱金 ,
  • 李丽 ,
  • 付铭洋
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  • (南京工业大学 食品与轻工学院, 江苏 南京, 211816)
博士, 副教授(通讯作者, E-mail:xuzheng@njtech.edu.cn)

收稿日期: 2020-07-21

  修回日期: 2020-08-31

  网络出版日期: 2021-03-31

基金资助

江苏省六大人才高峰项目(NY-056)

Recent advances on isomerases for bio-manufacturing

  • XU Zheng ,
  • XU Kai ,
  • CHEN Yujin ,
  • LI Li ,
  • FU Mingyang
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  • (College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China)

Received date: 2020-07-21

  Revised date: 2020-08-31

  Online published: 2021-03-31

摘要

异构体是指具有相同分子式而原子空间排布不同的化合物, 异构体现象在自然界中广泛存在, 例如常见的糖类、氨基酸、手性药物等化合物。催化异构体之间相互转化的反应即为异构反应, 生物体内的异构反应主要通过异构酶来实现。随着现代生物技术的不断发展, 越来越多的异构酶获得了挖掘、研究、应用, 多种化合物可以通过生物异构反应来制造, 这对于化工产业是强有力的补充与发展。研究人员结合自身工作, 综述了近年来异构酶在生物化工领域的研究与应用进展。

本文引用格式

徐铮 , 徐恺 , 陈昱金 , 李丽 , 付铭洋 . 异构酶在生物制造中的研究进展[J]. 食品与发酵工业, 2021 , 47(5) : 244 -251 . DOI: 10.13995/j.cnki.11-1802/ts.025135

Abstract

Isomers are chemical compounds that have the same molecular formula but different space arrangements of atoms. Isomers are widely existed in nature, including lots of sugar, amino acids, and chiral drugs. The transformation between different isomers is called isomerization. The isomerization reaction in vivo was mainly catalyzed by isomerases. With the development of modern biotechnology, more and more isomerases have been investigated and used for different applications. Lots of chemicals can be produced through catalysis of isomerases, showing a powerful supplementary to the chemical industry. Based on our research, recent studies of isomerization reactions in biochemical field were reviewed.

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