食品与发酵工业 >

2021 , Vol. 47 >Issue 14: 94 - 99

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.025923

研究报告

蒲公英不同提取物对酒精性肝损伤的保护作用

  • 夏金 ,
  • 陈义伦
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  • 山东农业大学 食品科学与工程学院,山东 泰安,271018
硕士研究生(陈义伦教授为通讯作者,E-mail:cylun@sdau.edu.cn)

收稿日期: 2020-10-21

  修回日期: 2020-12-11

  网络出版日期: 2021-08-20

基金资助

山东省农业重大应用技术创新项目(2130106)

收起

Protective effect of different dandelion extracts on alcoholic liver injury

  • XIA Jin ,
  • CHEN Yilun
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  • (College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China)

Received date: 2020-10-21

  Revised date: 2020-12-11

  Online published: 2021-08-20

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摘要

通过动物和细胞实验,研究蒲公英水提物、醇提物对酒精性诱导的肝损伤相关指标(谷草转氨酶、谷丙转氨酶、甘油三酯、丙二醛、超氧化物歧化酶、谷胱甘肽)的影响规律;在此基础上,分析蒲公英水提物、醇提物的体内、体外抗氧化特性,探究蒲公英提取物保肝作用机制。结果表明,蒲公英水提物、醇提物均具有保护酒精性肝损伤的作用;与醇提物相比,水提物作用剂量更低,能有效降低血清中谷草转氨酶和肝脏中谷胱甘肽的含量,更好地保护肝细胞线粒体;抗氧化特性及相关性分析表明,蒲公英提取物的保肝效果与其抗氧化作用密切相关。

关键词： 蒲公英; 提取物; 酒精性肝损伤; 抗氧化; 保肝

本文引用格式

夏金 , 陈义伦 . 蒲公英不同提取物对酒精性肝损伤的保护作用[J]. 食品与发酵工业, 2021 , 47(14) : 94 -99 . DOI: 10.13995/j.cnki.11-1802/ts.025923

Abstract

The effects of dandelion water extract and alcohol extract on alcohol-induced liver injury related indicators (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, triglyceride, malondialdehyde, superoxide dismutase, glutathione) were studied by animal and cell experiments. Then the antioxidant properties of water and alcohol extract of dandelion were determined in vitro and in vivo, and the liver-protecting mechanism of dandelion extract was explored. The results showed that both water extract and alcohol extract of dandelion had protective effect on alcoholic liver injury. Compared with alcohol extract, the water extract had lower action dose, and could effectively reduce the content of glutathione transaminase in serum and glutathione in liver, and better protect the mitochondria of hepatocytes. The antioxidant properties and correlation analysis showed that the liver protective effect of the dandelion extract was closely related to its antioxidant effect.

Key words： dandelion; extract; alcoholic liver injury; antioxidant; protect liver

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