综述与专题评论

铁皮石斛茎、叶、花的活性成分及综合利用研究进展

  • 严静 ,
  • 蔡易熹 ,
  • 陈燕兰 ,
  • 张慧莹 ,
  • 杜冰
展开
  • (华南农业大学 食品学院,广东 广州,510642)
硕士研究生(杜冰教授为通讯作者,E-mail:gzdubing@163.com)

收稿日期: 2020-12-08

  修回日期: 2020-12-17

  网络出版日期: 2021-09-27

基金资助

广东省重点领域研发计划项目(2020B020226008);广东省自然科学基金面上项目(2020A1515011268);广州城市职业学院科研团队项目(PK210201)

Research progress in active components and comprehensive utilization of stems,leaves and flowers of Dendrobium officinale

  • YAN Jing ,
  • CAI Yixi ,
  • CHEN Yanlan ,
  • ZHANG Huiying ,
  • DU Bing
Expand
  • (College of Food Science,South China Agricultural University,Guangzhou 510642,China)

Received date: 2020-12-08

  Revised date: 2020-12-17

  Online published: 2021-09-27

摘要

铁皮石斛是我国传统的名贵中药材,富含多种活性成分,备受人们青睐。铁皮石斛的药用部分为茎,随着铁皮石斛产品多样性不断丰富,非药用部分铁皮石斛叶和花的活性成分和加工利用方面也备受关注。该文从铁皮石斛茎、叶、花的活性成分和综合利用方面进行论述,旨在促进铁皮石斛叶和花的资源利用,促进铁皮石斛茎、叶、花相关产品的深加工,提高其附加值,为铁皮石斛茎、叶、花的综合利用提供有益借鉴。

本文引用格式

严静 , 蔡易熹 , 陈燕兰 , 张慧莹 , 杜冰 . 铁皮石斛茎、叶、花的活性成分及综合利用研究进展[J]. 食品与发酵工业, 2021 , 47(17) : 299 -306 . DOI: 10.13995/j.cnki.11-1802/ts.026336

Abstract

Dendrobium officinale is a traditional herbal Chinese medicine,which contains a variety of active components.The medicinal part of D.officinale is the stem.With the variety of D.officinale products,the active components and processing and utilization of D.officinale leaves and flowers were also concerned.In this article,the active components and comprehensive utilization of D.officinale stems,leaves and flowers were discussed,aiming to promote the utilization of resources of D.officinale leaves and flowers,promote the deep processing related products of stems,leaves and flowers of D.officinale,improve its added value,so as to provide a useful reference for the comprehensive utilization of D.officinale stems,leaves and flowers.

参考文献

[1] ZHAO Y,LIU Y,LAN X M,et al.Effect of Dendrobium officinale extraction on gastric carcinogenesis in rats[J].Evidence-Based Complementary and Alternative Medicine,2016,2016:1 213 090.
[2] FENG S G,HE R F,YANG S,et al.Start codon targeted (SCoT) and target region amplification polymorphism for evaluating the genetic relationship of Dendrobium species[J].Gene,2015,567(2):182-188.
[3] TANG H X,ZHAO T W,SHENG J J,et al.Dendrobium officinale Kimura et Migo:A review on its ethnopharmacology,phytochemistry,pharmacology,and industrialization[J].Evidence-Based Complementray and Alternative Medicine,2017:7 436 259.
[4] LUO Q L,TANG Z H,ZHANG X F,et al.Chemical properties and antioxidant activity of a water-soluble polysaccharide from Dendrobium officinale[J].International Journal of Biological Macromolecules,2016,89:219-227.
[5] WANG X J,TAO B,et al.Structural characterization and immunomodulating activity of polysaccharide from Dendrobium officinale[J].International Journal of Biological Macromolecules:Structure,Functionand Interactions,2016.
[6] CHEN H H,NIE Q X,HU J L,et al.Glucomannans alleviated the progression of diabetic kidney disease by improving kidney metabolic disturbance[J].Molecular Nutrition & Food Research,2019,63(12):e1801008.
[7] ZHENG H,PAN L L,XU P T,et al.An NMR-Based metabolomic approach to unravel the preventive effect of water-soluble extract from Dendrobium officinale Kimura & Migo on streptozotocin-induced diabetes in mice[J].Molecules,2017,22(9):1 543.
[8] XIA L J,LIU X F,GUO H Y,et al.Partial characterization and immunomodulatory activity of polysaccharides from the stem of Dendrobium officinale (Tiepishihu) in vitro[J].Journal Functional Foods,2012,4(1):294-301.
[9] 黄彪,何伟,吴建鸿,等.UPLC-MS/MS同时测定铁皮石斛茎、叶、花中酚类组分的含量[J].食品科学,2021,42(10):262-268.
HUANG B,HE W,WU J H,et al.Simultaneous determination of phenolic components in Dendrobium officinale stem,leave and flower by ultra high performance liquid chromatographytandem mass spectrometry[J].Food Science,2021,42(10):262-268.
[10] ZHANG Y,ZHANG L H,LIU J J,et al.Dendrobium officinale leaves as a new antioxidant source[J].Journal of Functional Foods,2017,37:400-415.
[11] LU H X,YANG K,ZHAN L H,et al.Optimization of flavonoid extraction in Dendrobium officinale leaves and their inhibitory effects on tyrosinase activity[J].International Journal of Analytical Chemistry,2019,2019:7 849 198.
[12] 张勇.铁皮石斛茎、叶、花多糖理化性质及抗氧化、免疫调节活性研究[D].杭州:浙江大学,2016.
ZHANG Y.Physicochemical properties,antioxidant and immunomodulatory activities of polysaccharides fr-om the stem,leaf and flower of Dendrobium officinale[D].Hangzhou:Zhejiang University,2016.
[13] 梁凯伦,方萍,施秋秋,等.铁皮石斛花对高糖高脂饮酒致高血压大鼠的降压作用及机制研究[J].中国中药杂志,2018,43(1):147-153.
LIANG K L,FANG P,SHI Q Q,et al.Antihypertensive effect and mechanism of Dendrobium officinale flos on high-blood pressure rats induced by high glucose and high fat compound alcohol[J].China Journalof Chinese Materia Medica,2018,43(1):147-153.
[14] 王楠楠,戴明珠,徐俞悦,等.铁皮石斛花对肾上腺皮质激素致肾阴虚模型小鼠的影响[J].中药药理与临床,2017,33(1):116-119.
WANG N N,DAI M Z,XU Y Y,et al.Effect of Dendrobium officinale flower on mice withadrenal hyperfunction[J].Pharmacology and Clinics of Chinese Materia Medica,2017,33(1):116-119.
[15] WANG D H,FAN B,WANG Y,et al.Optimum extraction,characterization,and antioxidant activitiesof polysaccharides from flowers of Dendrobium devonianum[J].International Journal of Analytical Chemistry,2018:3 013 497.
[16] ZHANG J Y,GUO Y,SI J P,et al.A polysaccharide of Dendrobium officinale ameliorates H2O2-induced apoptosis in H9c2 cardiomyocytes via PI3K/AKT and MAPK pathways[J].International Journal of Biological Macromolecules,2017,104(A):1-10
[17] ZENG Q,KO C H,SIU W S,et al.Polysaccharides of Dendrobium officinale Kimura & Migo protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo[J].Journal of Ethnopharmacology,2017,208:214-224.
[18] YU W X,REN Z Y,ZHANG X F,et al.Structural characterization of polysaccharides from Dendrobium of-ficinale and their effects on apoptosis of HeLa Cell Line[J].Molecules,2018,23(10).
[19] 曹雪原,唐雅楠,姜秀梅,等.铁皮石斛不同部位多糖含量及其抗氧化活性研究[J].食品与药品,2018,20(03):227-230.
CAO X Y,TANG Y N,JIANG X M,et al.Study on contents and antioxidant activity of polysaccharides in different parts of Dendrobium officinale Kimura et Migo[J].Food and Drug,2018,20(3):227-230.
[20] 周桂芬,庞敏霞,陈素红,等.铁皮石斛茎、叶多糖含量及多糖部位柱前衍生化-高效液相色谱指纹图谱比较研究[J].中国中药杂志,2014,39(5):795-802.
ZHOU G F,PANG M X,CHEN S H,et al.Comparison on polysaccharide content and PMP-HPLC fingerprints of polysaccharide in stems and leaves of Dendrobium officinale[J].China Journal of Chinese Materia Medica,2014,39(5):795-802.
[21] XIE S Z,LIU B,ZHANG DD,et al.Intestinal immunomodulating activity and structural characterization of a new polysaccharide from stems of Dendrobium officinale[J].Food & Function,2016,7(6):2 789-2 799.
[22] ZHANG X F,DUAN S N,TAO S C,et al.Polysaccharides from Dendrobium officinale inhibit proliferationof osteosarcoma cells and enhance cisplatin-induced apoptosis[J].Journal of Functional Foods,2020,73:104 143.
[23] XING X H,CUI S W,NIE S P,et al.Study on Dendrobium officinale O-acetyl-glucomannan (Dendronan®):Part II.Fine structures of O-acetylated residues[J].Carbohydrate Polymers,2015,117:422-433.
[24] YANG K,LU T T,ZHAN L H,et al.Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell[J].International Journal of Biological Macromolecules,2020,149:320-330.
[25] 张又元,陈乃伟,丁重阳,等.铁皮石斛茎部和叶部多糖的性质和活性[J].食品与生物技术学报,2017,36(9):959-965.
ZHANG Y Y,CHEN N W,DING C Y,et al.Characterization and bioactivity analysis of Dendrobium officinale stem and leaf polysacchride[J].Journal of Food Science and Biotechnology,2017,36(9):959-965.
[26] 张四杰,钱正,刘京晶,等.铁皮石斛花多糖相对分子质量及其单糖组成的研究[J].中国中药杂志,2017,42(20):3 919-3 925.
ZHANG S J,QIAN Z,LIU J J,et al.Relative molecular mass and monosaccharide composition of polysaccharide in Dendrobium officinale flowers[J].China Journal of Chinese Materia Medica,2017,42(20):3 919-3 925.
[27] GONZALEZ P S,O'PREY J,CARDACI S,et al.Mannose impairs tumour growth and enhances chemotherapy[J].Nature,2018,563(7 733):719-723.
[28] ZHANG D F,CHIA C,JIAO X,et al.D-mannose induces regulatory T cells and suppresses immunopathology[J].Nature Medicine,2017,23(9):1 036-1 045.
[29] 李芳,魏云,陈艳杰.铁皮石斛茎、叶、花中黄酮含量及其体外抗氧化活性研究[J].中医学报,2019,34(5):1 020-1 023.
LI F,WEI Y,CHEN Y J.Study on the content of flavonoids in stems,leaves and flowers of Dendrobiumofficinale Kimura & Migo and its antioxidant activity in vitro[J].China Journal of Chinese Medicine,2019,34(5):1 020-1 023.
[30] 张志信,张仕秀,谭福能.铁皮石斛不同部位生药红外光谱分析[J].文山学院学报,2019,32(3):13-17;21.
ZHANG Z X,ZHANG S X,TAN F N.Infrared spectrum analysis of different parts of Dendrobium officinale[J].Journal of Wenshan Teachers University,2019,32(3):13-17;21.
[31] 周桂芬, 吕圭源.铁皮石斛不同部位黄酮碳苷类成分及清除DPPH自由基能力比较研究[J].中国中药杂志,2012,37(11):1 536-1 540.
ZHOU G F,LV G Y.Comparative studies on scavenging DPPH freeradicals activity of flavone C-glycosides from different parts of Dendrobium officinale[J].China Journal of Chinese Materia Medica,2012,37(11):1 536-1 540.
[32] CHEN Y,WANG Y Z,LYU P,et al.Comparative transcriptomic analysis reveal the regulation me-chanism underlying MeJA-induced accumulation of alkaloids in Dendrobium officinale[J].Journal of Plant Research,2019,132:419-429.
[33] LIU J,ZHU T,NIU Q Q,et al.Dendrobium nobile alkaloids protects against H2O2-induced neuronal injury by suppressing JAK-STATs pathway activation in N2A cells[J].Biol Phar Bull,2020,43:716-724.
[34] 王亚芸,任建武.石斛碱的研究进展[J].山东农业大学学报(自然科学版),2015(1):152-158.
WANG Y Y,REN J W.The progress of study on Dendrobine[J].Journal of Shandong Agricultural University(Natural ence Edition),2015,46(36):152-158.
[35] 诸燕, 张爱莲,何伯伟,等.铁皮石斛总生物碱含量变异规律[J].中国中药杂志,2010,35(18):2 388-2 391.
ZHU Y,ZHANG A L,HE B W,et al.Quantitive variation of total alkaloids contents in Dendrobium officinale[J].China Journal of Chinese Materia Medica,2010,35(18):2 388-2 391.
[36] 尚喜雨.不同来源铁皮石斛不同部位生物碱的分布规律研究[J].安徽农业科学,2010,38(23):12 441-12 442.
SHANG X Y,Research on the distribution of the alkaloids in the different parts of the Dendrobium officinale with various origins[J].Journal of Anhui Agericultural Sciences,2010,38(23):12 441-12 442.
[37] 唐丽,李菁,龙华,等.不同生长龄铁皮石斛茎与叶中总多糖、总生物碱及总黄酮含量的差异[J].广东农业科学,2015,42(8):17-21.
TANG L,LI J,LONG H,et al.Content differences of total polysaccharides,total alkaloids and total flavonoids from stems and leaves of Dendrobium officinale at different growth ages[J].Guangdong Agricultural Sciences,2015,42(8):17-21.
[38] 李青,谢翠翠,李翔,等.铁皮石斛的化学成分及其在化妆品中的开发利用[J].日用化学工业,2017,47(2):109-113.
LI Q,XIE C C,LI X,et al.Chemical compositions of Dendrobium officinale and their development of applications in cosmetics[J].China Surfactant Detergent & Cosmetics,2017,47(2):109-113.
[39] 曲继旭,贺雨馨,陈龙,等.3种石斛氨基酸组成及营养评价[J].辽宁中医药大学学报,2018,20(2):60-62.
QU J X,HE Y X,CHEN L,et al.Determination of amino acids in three Dendrobium species and nutritional evaluation[J].Journal of Liaoning University of Traditional Chinese Medicine,2018,20(2):60-62.
[40] 刘振鹏,郭英英,刘京晶,等.铁皮石斛品系与部位对氨基酸含量的影响[J].中国中药杂志,2015,40(8):1 468-1 472.
LIU Z P,GUO Y Y,LIU J J,et al.Effect of strains and parts on amino acids of Dendrobium officinale[J].China Journal of Chinese Materia Medica,2015,40(8):1 468-1 472.
[41] 龚庆芳,何金祥,黄宁珍,等.铁皮石斛花化学成分及抗氧化活性研究[J].食品科技,2014,39(12):106-110.
GONG Q F,HE J X,HUANG N Z,et al.Chemical composition and antioxidant activities effects of Dendrobium officinale flower[J].Food Science and Technology,2014,39(12):106-110.
[42] GUO L H,QI J X,DU D,et al.Current advances of Dendrobium officinale polysaccharides in dermatology:A literature review[J].Pharmaceutical Biology,2020,58(1):664-673.
[43] LAM Y,NG T B,YAO R M,et al.Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants[J].Evidence-Based Complementary and Alternative Medicine,2015,2015:841 752.
[44] VIJAYENDRA S V N,SHAMALAT R.Film forming microbial biopolymers for commercial applications—A review[J].Critical Reviews in Biotechnology,2014,34(4):338-357.
[45] 张珍林,闵运江,刘明宇,等.铁皮石斛花保湿柔肤水配方工艺优化[J].轻工学报,2020,35(4):61-66.
ZHANG Z L,MIN Y H,LIU M Y,et al.Optimization of formulation process for Dendrobium officinale flower moisturizing toner[J].Journal of Light Industry,2020,35(4):61-66
[46] 李坚,冉周.石斛多糖的微生物发酵法提取及保湿功效研究[J].广东化工,2020,47(18):71-73.
LI J,RAN Z.Study on extraction and moisturizing effect of polysaccharides from Dendrobium officinale under fermentation[J].Guangdong Chemical industry,2020,47(18):71-73.
[47] 杨兵勋,于善凯,孙继军,等.铁皮石斛与大豆异黄酮提取物协同抗氧化作用评价[J].中国现代应用药学,2009,26(11):885-887.
YANG B X,YU S K,SUN J J,et al.Assessment of Dendrobium officinale and soybean isoflavone's synergistic antioxidative function[J].Chinese Journal of Modern Applied Pharmacy,2009,26(11):885-887.
[48] 赵文慧,马津真,聂晓静,等.铁皮石斛醇提取物对自发性高血压大鼠降压作用的研究[J].浙江中医杂志,2018,53(8):564-566.
ZHAO W H,MA J Z,NIE X J,et al.Study on the antihypertensive effect of Dendrobium officinale alcohol extract on spontaneously hypertensive rats[J].Zhejiang Journal of Traditional Chinese Medicine,2018,53(8):564-566.
[49] 马津真,赵文慧,聂晓静,等.不同方法提取的铁皮石斛提取物对自发性高血压大鼠的降压作用及其机制研究[J].中国现代应用药学,2018,35(12):1 811-1 816.
MA J Z,ZHAO W H,NIE X J,et al.Antihypertensiveeffect and mechanism of Dendrobii officinalis caulis extract by different extraction methods in spontaneously hypertensive rats[J].Chinese Journal of Modern Applied Pharmacy,2018,35(12):1 811-1 816.
[50] 陈思思,吴悦,任泽明,等.铁皮石斛叶和黄精单用及配伍对自发性高血压大鼠降压作用的研究[J].浙江中医杂志,2019,54(8):567-568.
CHEN S S,WU Y,REN Z M,et al.Study on the antihypertensive effect of Dendrobium officinale leaf and Radix polygoni multiflorum on spontaneously hypertensive rats[J].Zhejiang Journal of Traditional Chinese Medicine,2019,54(8):567-568.
[51] 何晓艳,吴人照,杨兵勋,等.铁皮石斛花对自发性高血压大鼠降压作用研究[J].浙江中医杂志,2016,51(2):152-154.
HE X Y,WU R Z,YANG B X,et al.Effect of Dendrobium officinale on blood pressure in spontaneously hypertensive rats[J].Zhejiang Journal of Traditional Chinese Medicine,2016,51(2):152-154.
[52] 季爱兵,曾胤,彭文书,等.铁皮石斛水提物对高脂血症小鼠血脂和血糖的影响[J].食品研究与开发,2017,38(3):176-180.
JI A B,ZENG Y,PENG W S,et al.Effect of water extract from Dendrobium officinale on blood lipid and blood sugar of mice with hyperlipemia[J].Food Research and Development,2017,38(3):176-180.
[53] 刘婷,苏洁,王娅君,等.复方铁皮石斛叶超微粉改善高脂血症小鼠的脂质代谢作用[J].现代食品科技,2020,36(4):18-24.
LIU T,SU J,WANG Y J,et al.Lipid metabolism of compound Dendrobium officinale leaf ultrafine powder on hyperlipidemia mice[J].Modern Food Science&Technology,2020,36(4):18-24.
[54] 姚尧,赵路,李军珂.铁皮石斛水提取物对糖尿病小鼠肠道微生物及脂类代谢的影响[J].中医药信息,2019,36(2):44-49.
TAO R,ZHAO L,LI J K.Effects of aqueous extract of Dendrobium officinale on intestinal microorganism and lipid metabolism in DM mice[J].Information on Traditional Chinese Medicine,2019,36(2):44-49.
[55] WANG K P,WANG H X,LIU Y G,et al.Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism[J].Journal of Functional Foods,2018,40:261-271.
[56] 莫建梅,刘莺燕,李庆国,等.“龙头凤尾”铁皮石斛基因鉴别及复方胶囊降血糖研究[J].江苏农业科学,2019,47(1):182-185.
MO J M,LIU Y Y,LI Q G,et al.Genetic identification of Dendrobium candidum and hypoglycemic effect of its compound capsules[J].Jiangsu Agricultural Sciences,2019,47(1):182-185.
[57] WANG R,SUN P,ZHOU Y,et al.Preventive effect of Dendrobium officinale Wall.ex Lindl.on activated carbon-induced constipation in mice[J].Experimental and Therapeutic Medicine,2015,9(2):563-568.
[58] LUO D D,QU C,LIN G S,et al.Character and laxative activity of polysaccharides isolated from Dendrobium officinale[J].Journal of Functional Foods,2017,34:106-117.
[59] 邓陈哲.铁皮石斛多糖对便秘小鼠肠道细菌多样性及相关酶活性的影响[J].中国临床药理学杂志,2018,34(15):1 875-1 877.
DENG C Z.Effects of Dendrobium polysaccharides on intestinal bacterial diversity and related enzyme activities in constipation mice[J].The Chinese Journal of Clinical Pharmacology,2018,34(15):1 875-1 877.
[60] 龙承星,贺璐,郭艳芳,等.铁皮石斛多糖对脾虚便秘小鼠免疫、肠道微生物及酶活性的影响[J].天然产物研究与开发,2017,29(6):1 020-1 024;1 034.
LONG C X,HE L,GUO Y F,et al.Effects of Dendrobium officinale polysaccharide on immunity,intestinal microbiota and enzyme activity in mice with spleen deficiency constipation[J].Natural Product Research and Development,2017,29(6):1 020-1 024;1 034.
[61] 王琪,赵维薇,陈雪玲,等.复合速溶茶粉制备工艺优化及功能成分分析[J].食品工业科技,2020,41(19):198-204;239.
WANG Q,ZHAO W W,CHEN X L,et al.Optimization of preparation process and analysis of functional components of compound instant tea powder[J].Science and Technology of Food Industry.2020,41(19):198-204;239.
[62] 张雅琼,丁作明,安彦峰,等.铁皮石斛药材不同加工方法的比较[J].中国民族民间医药,2015,24(1):39-41.
ZHANG Y Q,DING Z M,AN Y F,et al.The comparison of processing methods for traditional Chinese medicinal materials in Dendrobium officinale Wall.ex Lindl[J].Chinese Journal of Ethnomedicine and Ethnopharmacy,2015,24(1):39-41.
[63] 陆倩倩,杨薇,何靖,等.铁皮石斛液体口香糖的研制[J].山地农业生物学报,2020,39(4):82-87.
LU Q Q,YANG W,HE J,et al.Preparation of liquid gum of Dendrobium officinale[J].Journal of Mountain Agriculture and Biology,2020,39(4):82-87.
[64] 张蕊,范方宇,费海燕,等.铁皮石斛饼干加工工艺研究[J].粮食与油脂,2020,33(2):69-72.
ZHANG R,FAN F Y,FEI H Y,et al.Study on processing technology of Dendrobium officinale biscuits[J].Cereals & Oils,2020,33(2):69-72.
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