食品与发酵工业 >

2021 , Vol. 47 >Issue 22: 295 - 300

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.026913

综述与专题评论

电化学传感器在赭曲霉毒素A检测中的应用研究进展

  • 高栋 ,
  • 陈秀金 ,
  • 李兆周 ,
  • 王耀 ,
  • 何凯锋 ,
  • 王静 ,
  • 黄正迪 ,
  • 孙凤霞
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  • 1(河南科技大学 食品与生物工程学院,河南 洛阳,471000)
    2(食品加工与安全国家级实验教学示范中心,河南 洛阳,471000)
    3(石河子大学 食品学院,新疆 石河子,832003)
硕士研究生(陈秀金副教授为通讯作者,E-mail:chenxiujin9610@126.com)

收稿日期: 2021-01-30

  修回日期: 2021-03-12

  网络出版日期: 2021-12-16

基金资助

国家自然科学基金项目(31701694;31702218);河南省自然科学基金(182300410038);河南省青年人才托举工程项目(2020HYTP029);河南省高等学校青年骨干教师培养计划(2018GGJS048);河南科技大学食品与生物工程学院大学生研究训练计划(SP202003);石河子大学的自然科学基金(ZZZC201908A);石河子大学高层次人才科研启动项目(RCZK201920)

收起

Application and research progress of electrochemical sensors for the detection of ochratoxin A

  • GAO Dong ,
  • CHEN Xiujin ,
  • LI Zhaozhou ,
  • WANG Yao ,
  • HE Kaifeng ,
  • WANG Jing ,
  • HUANG Zhengdi ,
  • SUN Fengxia
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  • 1(College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China)
    2(National Demonstration Center for Experimental Food Processing and Safety Education, Luoyang 471000, China)
    3(School of Food Science and Technology, Shihezi University, Shihezi 832003, China)

Received date: 2021-01-30

  Revised date: 2021-03-12

  Online published: 2021-12-16

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摘要

赭曲霉毒素A (ochratoxin A,OTA) 是一种由曲霉菌和青霉菌等产生的次级代谢产物,广泛存在于各种食品、粮食和动物饲料中,具有强烈的肝毒性和肾毒性、免疫抑制、致畸、致癌和致突变作用,严重危害人类健康。传统的OTA分析方法检测成本高,操作复杂且灵敏度低,限制了其应用领域。因此,亟需开发一种低成本、高灵敏度、准确快速的OTA检测方法。电化学传感器具有便携、价廉和快速的优势,具有很好的应用前景。该文对检测OTA的电化学传感器(电化学免疫传感器、分子印迹电化学传感器、电化学适配体传感器和其他电化学传感器)的机理和优缺点进行综述,并对OTA电化学传感器发展方向进行了展望。

关键词： 赭曲霉毒素A; 电化学免疫传感器; 分子印迹电化学传感器; 电化学适配体传感器; 其他电化学传感器

本文引用格式

高栋 , 陈秀金 , 李兆周 , 王耀 , 何凯锋 , 王静 , 黄正迪 , 孙凤霞 . 电化学传感器在赭曲霉毒素A检测中的应用研究进展[J]. 食品与发酵工业, 2021 , 47(22) : 295 -300 . DOI: 10.13995/j.cnki.11-1802/ts.026913

Abstract

Ochratoxin A(OTA)is a secondary metabolite produced by fungi such as Aspergillus and Penicillium. It extensively exists in a variety of products, such as food, grain and animal feed. It also has a stronger hepatotoxicity, nephrotoxicity, teratogenic, carcinogenic and mutagenic effect, which seriously endangered human health. The disadvantages of traditional OTA analysis methods, such as high cost, complex operation and low sensitivity limit their application fields. Therefore, it is imperative to develop a low cost, highly sensitive, accurate, and rapid method for the detection of OTA. Electrochemical sensors have the advantages of portability, low price and fast, so they have a good application prospect. This review summarizes the mechanism, advantages and disadvantages of electrochemical sensors for the detection of OTA, such as electrochemical immunosensors, molecularly imprinted electrochemical sensors, electrochemical aptasensors and other electrochemical sensors, and prospects the development of electrochemical sensors for OTA determination in the future.

Key words： ochratoxin A; electrochemical immunosensors; molecularly imprinted electrochemical sensors; electrochemical aptasensors; other electrochemical sensors

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