[1] GABRIELLI O,ZAMPINI L,GALEAZZI T,et al.Preterm milk oligosaccharides during the first month of lactation[J].Pediatrics,2011,128(6):e1520-e1531.
[2] ANDERSON A,DONALD A S.Improved method for the isolation of 2' fucosyllactose from human milk[J].Journal of Chromatography A,1981,211(1):170-174.
[3] HEINONEN I M.Safety of 2'-O-fucosyllactose as a novel food ingredient pursuant to regulation(EC) No 258/97[J].EFSA Journal,2015,13(7):4 184.
[4] BYCH K,MIKŠ M H,JOHANSON T,et al.Production of HMOs using microbial hosts-from cell engineering to large scale production[J].Current Opinion in Biotechnology,2019,56:130-137.
[5] SHI R,MA J W,YAN Q J,et al.Biochemical characterization of a novel α-L-fucosidase from Pedobacter sp.and its application in synthesis of 3extasciiacutex-fucosyllactose and 2extasciiacutex-fucosyllactose[J].Applied Microbiology and Biotechnology,2020,104(13):5 813-5 826.
[6] 温晓鹿,王丽,杨雪芬,等.合生素替代抗生素对断奶仔猪生长性能、肠道黏膜形态与免疫性能及结肠微生态的影响[J].动物营养学报,2019,31(5):2 088-2 097.
WEN X L,WANG L,YANG X F,et al.Effects of synbiotics substitution of antibiotics on growth performance,intestinal mucosal morphology,immune performance and colonic microbial ecosystem of weaned piglets[J].Chinese Journal of Animal Nutrition,2019,31(5):2 088-2 097.
[7] 刘爽,王津,邹妍,等.2'-岩藻糖基乳糖的功能及其应用现状[J].营养学报,2020,42(2):187-192.
LIU S,WANG J,ZOU Y,et al.The health benefits of 2'-fucosyllactose and its application in infant formula products[J].Acta Nutrimenta Sinica,2020,42(2):187-192.
[8] HICKEY R M.The role of oligosaccharides from human milk and other sources in prevention of pathogen adhesion[J].International Dairy Journal,2012,22(2):141-146.
[9] WEICHERT S,JENNEWEIN S,HÜFNER E,et al.Bioengineered 2'-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines[J].Nutrition Research(New York,N.Y.),2013,33(10):831-838.
[10] ZHANG G F,ZHAO J J,WEN R,et al.2'-Fucosyllactose promotes Bifidobacterium bifidum DNG6 adhesion to Caco-2 cells[J].Journal of Dairy Science,2020,103(11):9 825-9 834.
[11] GOEHRING K C,MARRIAGE B J,OLIVER J S,et al.Similar to those who are breastfed,infants fed a formula containing 2'-fucosyllactose have lower inflammatory cytokines in a randomized controlled trial[J].The Journal of Nutrition,2016,146(12):2 559-2 566.
[12] XIAO L,LEUSINK-MUIS T,KETTELARIJ N,et al.Human milk oligosaccharide 2'-fucosyllactose improves innate and adaptive immunity in an influenza-specific murine vaccination model[J].Frontiers in Immunology,2018,9:452.
[13] ZEHRA S,KHAMBATI I,VIERHOUT M,et al.Human milk oligosaccharides attenuate antigen-antibody complex induced chemokine release from human intestinal epithelial cell lines[J].Journal of Food Science,2018,83(2):499-508.
[14] LI A L,NI W W,LI Y,et al.Effect of 2'-fucosyllactose supplementation on intestinal flora in mice with intestinal inflammatory diseases[J].International Dairy Journal,2020,110:104797.
[15] FACINELLI B,MARINI E,MAGI G,et al.Breast milk oligosaccharides:Effects of 2'-fucosyllactose and 6'-sialyllactose on the adhesion of Escherichia coli and Salmonella fyris to Caco-2 cells[J].The Journal of Maternal-Fetal & Neonatal Medicine,2019,32(17):2 950-2 952.
[16] VÁZQUEZ E,BARRANCO A,RAMÍREZ M,et al.Effects of a human milk oligosaccharide,2'-fucosyllactose,on hippocampal long-term potentiation and learning capabilities in rodents[J].The Journal of Nutritional Biochemistry,2015,26(5):455-465.
[17] MATTHIES H,STAAK S,KRUG M.Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation[J].Brain Research,1996,725(2):276-280.
[18] AGOSTON K,HEDEROS M J,BAJZA I,et al.Kilogram scale chemical synthesis of 2'-fucosyllactose[J].Carbohydrate Research,2019,476:71-77.
[19] CHIN Y W,KIM J Y,LEE W H,et al.Enhanced production of 2'-fucosyllactose in engineered Escherichia coli BL21 star(DE3) by modulation of lactose metabolism and fucosyltransferase[J].Journal of Biotechnology,2015,210:107-115.
[20] BAUMGÄRTNER F,SEITZ L,SPRENGER G A,et al.Construction of Escherichia coli strains with chromosomally integrated expression cassettes for the synthesis of 2'-fucosyllactose[J].Microbial Cell Factories,2013,12(1):40.
[21] NI Z J,LI Z K,WU J Y,et al.Multi-path optimization for efficient production of 2'-fucosyllactose in an engineered Escherichia coli C41(DE3) derivative[J].Frontiers in Bioengineering and Biotechnology,2020,8:611900.
[22] 马婉晴,章珍,刘悦琳,等.大肠杆菌分解代谢产物阻遏效应研究进展[J].遗传,2010,32(6):571-576.
MA W Q,ZHANG Z,LIU Y L,et al.Advances in mechanism of Escherichia coli carbon catabolite repression[J].Hereditas(Beijing),2010,32(6):571-576.
[23] DROUILLARD S,DRIGUEZ H,SAMAIN E.Large-scale synthesis of H-antigen oligosaccharides by expressing Helicobacter pylori alpha1,2-fucosyltransferase in metabolically engineered Escherichia coli cells[J].Angewandte Chemie(International Ed.in English),2006,45(11):1 778-1 780.
[24] HUANG D,YANG K X,LIU J,et al.Metabolic engineering of Escherichia coli for the production of 2'-fucosyllactose and 3-fucosyllactose through modular pathway enhancement[J].Metabolic Engineering,2017,41:23-38.
[25] PARSCHAT K,SCHREIBER S,WARTENBERG D,et al.High-titer de novo biosynthesis of the predominant human milk oligosaccharide 2'-fucosyllactose from sucrose in Escherichia coli[J].ACS Synthetic Biology,2020,9(10):2 784-2 796.
[26] HOLLANDS K,BARON C M,GIBSON K J,et al.Engineering two species of yeast as cell factories for 2'-fucosyllactose[J].Metabolic Engineering,2019,52:232-242.
[27] DENG J Y,CHEN C M,GU Y,et al.Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis[J].Metabolic Engineering,2019,55:179-190.
[28] YU S,LIU J J,YUN E J,et al.Production of a human milk oligosaccharide 2'-fucosyllactose by metabolically engineered Saccharomyces cerevisiae[J].Microbial Cell Factories,2018,17(1):1-10.
[29] LI C,WU M,GAO X,et al.Efficient biosynthesis of 2'-fucosyllactose using an in vitro multienzyme cascade[J].Journal of Agricultural and Food Chemistry,2020,68(39):10 763-10 771.
[30] CHIN Y W,KIM J Y,KIM J H,et al.Improved production of 2'-fucosyllactose in engineered Escherichia coli by expressing putative α-1,2-fucosyltransferase,WcfB from Bacteroides fragilis[J].Journal of Biotechnology,2017,257:192-198.
[31] JUNG S M,CHIN Y W,LEE Y G,et al.Enhanced production of 2'-fucosyllactose from fucose by elimination of rhamnose isomerase and Arabinose isomerase in engineered Escherichia coli[J].Biotechnology and Bioengineering,2019,116(9):2 412-2 417.
[32] CHIN Y W,SEO N,KIM J H,et al.Metabolic engineering of Escherichia coli to produce 2'-fucosyllactose via salvage pathway of guanosine 5'-diphosphate(GDP)-L-fucose[J].Biotechnology and Bioengineering,2016,113(11):2 443-2 452.
[33] SEYDAMETOVA E,YU J,SHIN J,et al.Search for bacterial α1,2-fucosyltransferases for whole-cell biosynthesis of 2'-fucosyllactose in recombinant Escherichia coli[J].Microbiological Research,2019,222:35-42.
[34] CHEN Q,WU H Y,JI,M H,et al.Engineering a colanic acid biosynthesis pathway in E.coli for manufacturing 2'-fucosyllactose[J].Process Biochemistry,2020,94:79-85.
