《生物分离工程》是生物工程学科领域的核心课程,但传统实验教学模式难以开展生物分离工程综合性专业实验。利用虚拟仿真技术和互联网技术构建虚拟仿真实验系统,有利于破解时空障碍,推进生物技术领域工程教育的改革。该文着重介绍了工业尺度的生物分离工程综合性虚拟仿真实验教学系统的建设思路。为了激发学生的主观能动性与创新意识,以培养利用专业知识解决生物分离工程实际问题的能力为实验教学目标,以典型生物农药多抗菌素的规模化分离提取为实验任务导向,实验内容涵盖分离技术、分离设备与过程控制。教学实践表明:生物分离工程综合性虚拟仿真实验教学系统具有极高的教学效率,实现理论知识与应用实践的融合,改变了灌输式的实验教学手段,激发了学生的主观能动性与创新意识,提升了学生的专业能力与素养。
Bioseparation engineering is one of the core courses in bioengineering,but it is difficult to carry on the comprehensive specialized experiments of bioseparation by traditional experiment teaching mode.Virtual simulation experiment system is constructed by virtual simulation and internet technology,which can break the barriers of time-space and promote engineering education reform in biological technology field.The construction thoughts of virtual simulation comprehensive experiment teaching system for scale bioseparation were introduced in this paper.To stimulate students' subjective initiative and innovative consciousness,the abilities using professional knowledge to solve practical bioseparation problems are developed as experiment teaching objectives,the scale separation of polyoxin was made as experimental mission.The experimental contents covered separation technology,separation devices and process controls.The result of teaching practice showed that virtual simulation comprehensive bioseparation experiment teaching system enhances the teaching efficiency obviously.The theoretical knowledge is combined with application practice and “spoon-feed” teaching method is changed in this experiment.The subjective initiative and innovative consciousness of students are activated.The ability and accomplishment of students are also enhanced.
[1] 胡永红,何淑冰,俞苏洋.高校专业教育与创新创业教育融合的教学模式改革探索——以“生物分离工程”课程为例[J].创新创业理论研究与实践,2020,3(13):110-113.
[2] 栗孟飞,张真,孙萍,等.科研反哺综合模式在生物分离工程教学中的应用[J].生物学杂志,2020,37(2):110-112.
[3] 徐军伟,韩本勇,李涛,等.工程教育认证下《生物分离工程》课程教学改革探索与实践[J].广东化工,2021,48(4):209-210.
[4] 杨杰,孙丹枫,张丽娟,等.汽车检测与维修虚拟仿真实验教学资源建设[J].时代汽车,2020(23):21-25.
[5] 杨万霞. “互联网+”背景下高校虚拟仿真实验教学体系的构建与应用[J].吉林省教育学院学报,2021,37(2):116-119.
[6] 张志宾,刘云海,谢宗波,等.“新工科”建设背景下地方普通高校化工虚拟仿真实验教学体系的探讨[J].教育现代化,2019,6(55):97-98.
[7] 杨建华,姚池,刘成林,等.水利工程虚拟仿真实验教学中心的建设[J].实验技术与管理,2018,35(1):245-248;265.
[8] ALI N M,ULLAH S.Review to analyze and compare virtual chemistry laboratories for their use in education[J].Journal of Chemical Education,2020,97(10):3 563-3 574.
[9] DOMINGUES L,ROCHA I,DOURADO F,et al.Virtual laboratories in(bio)chemical engineering education[J].Education for Chemical Engineers,2010,5(2):e22-e27.
[10] MARTÍN-LARA M Á,RONDA A.Implementation of modeling tools for teaching biorefinery(focused on bioethanol production) in biochemical engineering courses:Dynamic modeling of batch,semi-batch,and continuous well-stirred bioreactors[J].Energies,2020,13(21):5 772.
[11] DE LAS HERAS S C,KENSINGTON-MILLER B,YOUNG B,et al.Benefits and challenges of a virtual laboratory in chemical and biochemical engineering:Students' experiences in fermentation[J].Journal of Chemical Education,2021,98(3):866-875.
[12] 谢晖,罗艳霞,沈晓敏,等.虚拟仿真课程的“行为-能力”双模态智能评价——以“现代工科微生物学仿真实验”课程为例[J].现代教育技术,2020,30(10):105-111.
[13] 杨文婷,杨立,黄静,等.啤酒发酵虚拟仿真项目在发酵工程系列课程的应用与实践[J].山东化工,2019,48(3):116-118.
[14] 常雅宁,彭钰珂,魏东芝,等.虚拟仿真技术在酶工程实验教学上的应用[J].实验室研究与探索,2019,38(2):237-239;244.
[15] 何书英,刘煜,郑珩,等.生物制药虚拟仿真实验教学平台的建设与应用[J].实验技术与管理,2017,34(8):118-120;161.
[16] 杨旭,胡晓龙,宋丽丽,等.虚拟仿真实验平台助力白酒酿造工艺实践教学[J].食品与发酵工业,2021,47(5):309-314.
[17] 欧阳平凯, 胡永红,姚忠.生物分离原理及技术[M].3版.北京:化学工业出版社,2019.
[18] 张敏,刘俊波.对高校虚拟仿真实验教学项目建设的若干思考[J].中国现代教育装备,2020(1):10-13.
[19] 张玉皓,胡永红,邓人伦,等.农用抗生素多抗菌素高产菌株的诱变及发酵优化[J].中国科技论文,2017,12(24):2 857-2 862.
