为优化桑叶提取物压片糖果的造粒工艺,采用单因素实验分别研究高速造粒机喷枪压力、制粒刀转速和蠕动泵转速对于粉体流动性指数和平均粒径的影响。并在此基础上,选择造粒机喷枪压力、制粒刀转速和蠕动泵转速3个条件为考察因素,以粉体特性指标流动性指数和粉体平均粒径为响应值,采用Design Expert 8.0软件中Box-Benhnken中心组合设计3因素3水平响应面实验。通过建立响应面回归模型并对实验结果进行统计分析,证明了喷枪压力、制粒刀转速和蠕动泵转速对于粉体流动性指数和平均粒径有显著性影响。最优粉体造粒工艺为喷枪压力0.5 MPa,制粒刀转速2 600 r/min,蠕动泵转速2.6 r/min,该条件下粉体流动性指数为77.8,平均粒径为127.11 μm,具有良好的流动性。
In order to optimize the granulation process of mulberry leaf extract tableting candy, single factor experiments were used to estimate the effects of spray gun pressure, granulation knife speed and rotating speed of the peristaltic pump on powder fluidity index and average particle size. And based on this, the spray gun pressure, granulation knife speed and rotating speed of the peristaltic pump were selected as the investigation factors, and powder fluidity index and average particle size were used as the response value. The central combination design of Box-Benhnken was designed using Design Expert 8.0 software including three-factor and three-level response surface experiments. Through the establishment of response surface regression model and statistical analysis of the experimental results, it was proved that the spray gun pressure, granulation knife speed and rotating speed of the peristaltic pump had a significant influence on the powder fluidity index and the average particle size. The optimized powder granulation process was as follows: the pressure of spray gun was 0.5 MPa, the speed of granulating knife was 2 600 r/min, and the speed of peristaltic pump was 2.6 r/min. Under these conditions, the powder fluidity index and average particle size were 77.8 μm and 127.11 μm, respectively, and the powder had good fluidity.
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