重金属铅摄入对生物体造成不利影响,严重时引发肾脏和肝脏的不可逆损伤。植物乳植杆菌被认为是重要的益生菌,对生物体产生诸多益处。该研究旨在阐明植物乳植杆菌CCFM8661对铅中毒小鼠毒性作用的缓解效果。该研究针对BALB/c小鼠,灌胃醋酸铅水溶液建立铅中毒小鼠模型,利用酶联免疫试验、组织病理学等方法测定补充植物乳植杆菌CCFM8661对铅中毒小鼠的毒性作用的缓解效果。结果发现,模型组的体重、抗氧化能力、组织病理以及组织含铅量较对照组相比均发生显著的负面变化,说明造模有效。补充植物乳植杆菌CCFM8661能够逆转模型组中的体重、抗氧化能力、组织病理学以及组织含铅量的恶化,缓解铅中毒小鼠的毒性作用。该研究为开发针对慢性铅中毒的益生菌治疗方法提供了理论依据。
Heavy metal lead ingestion can have detrimental effects on organisms, leading to irreversible damage to the kidneys and liver.Lactiplantibacillus plantarum is considered an important probiotic and has been recognized for its various advantages for organisms.This study aimed to investigate the protective effect of L. plantarum CCFM8661 against lead toxicity in mice.Using BALB/c mice, a lead poisoning mouse model was established by orally administering lead acetate solution.Enzyme-linked immunosorbent assay and histopathology were employed to evaluate the mitigating effect of L. plantarum CCFM8661 on lead toxicity in mice.Results revealed significant negative changes in body weight, antioxidant capacity, kidney tissue pathology, and tissue lead content in the model group compared to the control group, indicating the successful establishment of the model.However, supplementation with L. plantarum CCFM8661 reversed the deterioration observed in the model group, including body weight, antioxidant capacity, histopathology, and tissue lead content.Consequently, this study provides a theoretical foundation for developing probiotic treatment methods targeting chronic lead poisoning.
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