综述与专题评论

普拉梭菌与结肠炎关系的研究进展

  • 黄佳慧 ,
  • 薛营 ,
  • 周瑶 ,
  • 赵凯
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  • 1(齐齐哈尔大学 生命科学与农林学院,黑龙江 齐齐哈尔,161006)
    2(台州学院 生命科学学院,浙江省植物进化生态学与保护重点实验室,台州市生物医药与高端剂型重点实验室,浙江 台州,318000)
第一作者:硕士研究生(周瑶副教授和赵凯教授为共同通信作者,E-mail:zhouyao830226@163.com;zybin395@126.com)

收稿日期: 2024-05-26

  修回日期: 2024-08-12

  网络出版日期: 2025-04-29

基金资助

浙江省‘尖兵’‘领雁’研发攻关计划项目(2022C02031);浙江省重点研发计划项目(2021C02049);台州市科技计划项目(22gyb01,23gya02)

Research progress on the relationship between Faecalibacterium prausnitzii and colitis

  • HUANG Jiahui ,
  • XUE Ying ,
  • ZHOU Yao ,
  • ZHAO Kai
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  • 1(College of Life Science and Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China)
    2(Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Taizhou University, Taizhou 318000, China)

Received date: 2024-05-26

  Revised date: 2024-08-12

  Online published: 2025-04-29

摘要

炎症性肠病是一种破坏胃肠道的慢性、复发性、炎症性肠道疾病。肠道菌群长期存在于人类胃肠道中,对人体产生局部和全身作用,并与炎症性肠病的发生和发展密切相关。普拉梭菌是一种肠道共生菌,该菌及其外囊泡和代谢产物能够改善结肠炎,但其具体作用机制尚未阐明。该文综述了普拉梭菌及其代谢产物在肠道屏障方面对结肠炎的作用,并介绍了应用下一代益生菌,粪便移植和丁酸盐治疗炎症性肠病存在的挑战与问题,以期为炎症性肠病的治疗提供理论参考。

本文引用格式

黄佳慧 , 薛营 , 周瑶 , 赵凯 . 普拉梭菌与结肠炎关系的研究进展[J]. 食品与发酵工业, 2025 , 51(7) : 371 -377 . DOI: 10.13995/j.cnki.11-1802/ts.040009

Abstract

Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disorder that damages the gastrointestinal tract.The gut microbiota, which resides in the human gastrointestinal tract, plays a crucial local and systemic role and is closely related to the onset and progression of IBD.Faecalibacterium prausnitzii is a type of gut symbiotic bacteria whose extracellular vesicles and metabolic products have been shown to ameliorate colitis, but the specific mechanisms of action remain unclear.This article reviews the effects of F. prausnitzii and its metabolites on intestinal barrier function in relation to colitis and discusses the challenges and issues associated with the application of next-generation probiotics, fecal transplantation, and butyrate therapy for treating IBD, aiming to provide theoretical references for the treatment of IBD.

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