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响应第二信使分子环状二核苷酸的细菌核糖开关研究进展

  • 刘政言 ,
  • 宋馨 ,
  • 王光强 ,
  • 夏永军 ,
  • 艾连中 ,
  • 熊智强
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  • 1(上海理工大学 健康科学与工程学院,上海食品微生物工程研究中心,上海,200093)
    2(上海交通大学 农业与生物学院,上海,200240)
第一作者:硕士研究生(熊智强教授为通信作者,E-mail:xiongzq@hotmail.com)

收稿日期: 2025-01-13

  修回日期: 2025-03-24

  网络出版日期: 2025-10-27

基金资助

国家自然科学基金面上项目(2272300);国家自然科学基金区域创新发展联合基金重点项目(U22A20550)

Advances in bacterial riboswitch response to second messenger molecule cyclic dinucleotides

  • LIU Zhengyan ,
  • SONG Xin ,
  • WANG Guangqiang ,
  • XIA Yongjun ,
  • AI Lianzhong ,
  • XIONG Zhiqiang
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  • 1(Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
    2(School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China)

Received date: 2025-01-13

  Revised date: 2025-03-24

  Online published: 2025-10-27

摘要

第二信使分子在细菌响应外界环境变化的信号传导过程中发挥重要作用。环状二核苷酸(cyclic dinucleotides,CDG)是一类新发现的第二信使分子包括环二鸟苷酸(cyclic diguanosine monophosphate,c-di-GMP)和环二腺苷酸(cyclic diadenosine monophosphate,c-di-AMP),调控细菌细胞壁代谢、钾离子稳态、生物膜形成和DNA修复等生理功能。为理解CDG分子调控机制,该文综述了响应CDG的核糖开关结构及其调控机制,通过系统分析CDG核糖开关对基因表达的调控作用,旨在深化对信号转导机制的理解,以期为第二信使分子介导的信号网络调控研究提供借鉴。

本文引用格式

刘政言 , 宋馨 , 王光强 , 夏永军 , 艾连中 , 熊智强 . 响应第二信使分子环状二核苷酸的细菌核糖开关研究进展[J]. 食品与发酵工业, 2025 , 51(20) : 378 -385 . DOI: 10.13995/j.cnki.11-1802/ts.042083

Abstract

Second messenger molecules play an important role in signaling in bacteria in response to changes in the external environment.Cyclic dinucleotides (CDG) are a newly discovered class of second messenger molecules, including c-di-GMP and c-di-AMP, which regulate the physiological functions of bacterial cell wall metabolism, potassium ion homeostasis, biofilm formation, and DNA repair.In order to understand the regulatory mechanism of CDG, this paper reviews the structure and regulatory mechanism of CDG riboswitches, and systematically analyzes the regulatory effect of CDG riboswitches on gene expression, aiming to deepen the understanding of signal transduction mechanism, which provide a reference for the study of the second messenger molecule-mediated signal network regulations.

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