[1] 李思怡, 姜雨彤, 妥彦峰, 等.微生物发酵法制备乳源生物活性肽研究进展[J].食品科学, 2023, 44(21):312-321.
LI S Y, JIANG Y T, TUO Y F, et al.Research progress in preparation of bioactive peptides from milk by microbial fermentation[J].Food Science, 2023, 44(21):312-321.
[2] 库尔旦·胡达依别尔根, 刘学莲, 卡吾萨尔·恰依马尔旦, 等.分离、鉴定和筛选具有益生特性和降胆固醇能力的发酵马乳源益生菌[J].食品与发酵工业, 2025, 51(11):171-178.
KURDAN H, LIU X L, KAWUSAER Q, et al.Isolation, identification, and screening of probiotic strains with cholesterol-lowering potential from fermented mare’s milk[J].Food and Fermentation Industries, 2025, 51(11):171-178.
[3] 付英杰, 张启东, 范武, 等.组学技术在食品风味解析中的应用研究进展[J].河南工业大学学报(自然科学版), 2025, 46(3):135-147.
FU Y J, ZHANG Q D, FAN W, et al.Research progress on the applications of omics technologies in food flavor analysis[J].Journal of Henan University of Technology (Natural Science Edition), 2025, 46(3):135-147.
[4] 朱华伟, 李寅.合成生物制造2025[J].生物工程学报, 2025, 41(1):1-78.
ZHU H W, LI Y.Biomanufacturing driven by engineered organisms[J].Chinese Journal of Biotechnology, 2025, 41(1):1-78.
[5] YU Y, LIU S C, ZHANG X C, et al.Identification and prediction of milk-derived bitter taste peptides based on peptidomics technology and machine learning method[J].Food Chemistry, 2024, 433:137288.
[6] 钱宇辰, 聂挺, 花彦铭, 等.人工智能算法在抗菌肽预测领域的应用[J].食品科学, 2025, 46(11):384-393.
QIAN Y C, NIE T, HUA Y M, et al.Application of artificial intelligence algorithms in the field of antimicrobial peptide prediction[J].Food Science, 2025, 46(11):384-393.
[7] 王姝, 徐春明.深度学习在抗菌肽设计、发现与预测中的应用:现状与展望[J].食品与发酵工业, 2024, 50(21):366-378.
WANG S, XU C M.Application of deep learning in the design, discovery, and prediction of antimicrobial peptides:Current status and prospects[J].Food and Fermentation Industries, 2024, 50(21):366-378.
[8] 孙雪姣, 李蕊, 刘雨萌, 等.乳中生物活性肽对人体健康影响的研究进展[J].乳业科学与技术, 2018, 41(3):42-46.
SUN X J, LI R, LIU Y M, et al.Recent progress of research on health benefits of bioactive peptides derived from milk proteins for humans[J].Journal of Dairy Science and Technology, 2018, 41(3):42-46.
[9] SRIVASTAVA U, NATARAJ B H, KUMARI M, et al.Antioxidant and immunomodulatory potency of Lacticaseibacillus rhamnosus NCDC24 fermented milk-derived peptides:A computationally guided in-vitro and ex-vivo investigation[J].Peptides, 2022, 155:170843.
[10] ABEDIN M M, CHOURASIA R, CHIRING PHUKON L, et al.Characterization of ACE inhibitory and antioxidant peptides in yak and cow milk hard chhurpi cheese of the Sikkim Himalayan region[J].Food Chemistry:X, 2022, 13:100231.
[11] CHOURASIA R, ABEDIN M M, PHUKON L C, et al.Unearthing novel and multifunctional peptides in peptidome of fermented chhurpi cheese of Indian Himalayan region[J].Food Research International, 2025, 201:115651.
[12] BROWN L, PINGITORE E V, MOZZI F, et al.Lactic acid bacteria as cell factories for the generation of bioactive peptides[J].Protein and Peptide Letters, 2017, 24(2):146-155.
[13] HARPER A R, DOBSON R C J, MORRIS V K, et al.Fermentation of plant-based dairy alternatives by lactic acid bacteria[J].Microbial Biotechnology, 2022, 15(5):1404-1421.
[14] VENEGAS-ORTEGA M G, FLORES-GALLEGOS A C, MARTÍNEZ-HERNÁNDEZ J L, et al.Production of bioactive peptides from lactic acid bacteria:A sustainable approach for healthier foods[J].Comprehensive Reviews in Food Science and Food Safety, 2019, 18(4):1039-1051.
[15] DALIRI E B, LEE B H, PARK B J, et al.Antihypertensive peptides from whey proteins fermented by lactic acid bacteria[J].Food Science and Biotechnology, 2018, 27(6):1781-1789.
[16] TANG H W, PHAPUGRANGKUL P, FAUZI H M, et al.Lactic acid bacteria bacteriocin, an antimicrobial peptide effective against multidrug resistance:A comprehensive review[J].International Journal of Peptide Research and Therapeutics, 2021, 28(1):14.
[17] ZHANG J, XIAO Y, WANG H C, et al.Lactic acid bacteria-derived exopolysaccharide:Formation, immunomodulatory ability, health effects, and structure-function relationship[J].Microbiological Research, 2023, 274:127432.
[18] ABDUL HAKIM B N, XUAN N J, OSLAN S N H.A comprehensive review of bioactive compounds from lactic acid bacteria:Potential functions as functional food in dietetics and the food industry[J].Foods, 2023, 12(15):2850.
[19] 姚松青.羊肉中活性肽的抗氧化功能及应用研究[D].成都:成都大学, 2024.
YAO S Q.Research on the antioxidant function and application of active peptides in mutton[D].Chengdu:Chengdu University, 2024.
[20] 赵以轩,马臻棋,王学红.Irisin在胃肠道恶性肿瘤疾病中的研究进展[J].现代消化及介入诊疗, 2024, 29(8):1015-1020.
ZHAO Y X,MA Z Q,WANG X H.Research progress of Irisin in gastrointestinal malignant tumor diseases[J].Modern Interventional Diagnosis and Treatment in Gastroenterology, 2024, 29(8):1015-1020.
[21] 赵烜影.水牛β-酪蛋白亚型结构表征及体外消化和抗氧化性能分析[D].哈尔滨:东北农业大学, 2018.
ZHAO X Y.Structure characterization, digestion in vitro and antioxidation of β-casein phenotypes in buffalo[D].Harbin:Northeast Agricultural University, 2018.
[22] 张凯, 刘媛, 王健, 等.固定化酶ESM-BAP酶解制备甜杏仁ACE抑制肽及其工艺优化[J].农产品加工, 2024(10):47-52;56.
ZHANG K, LIU Y, WANG J, et al.Preparation of ACE-inhibiting peptide from sweet almond by enzymatic digestion with immobilized enzyme ESM-BAP and its process optimization[J].Farm Products Processing, 2024(10):47-52;56.
[23] 冯钰瑶, 米顺利.藻类活性肽的功能活性和应用研究进展[J].食品科技, 2022, 47(3):259-264.
FENG Y Y, MI S L.Active functions and application research progress of algal peptides[J].Food Science and Technology, 2022, 47(3):259-264.
[24] 张文静, 毛咏荷, 李宁, 等.酸羊乳发酵及其健康功效研究进展[J].中国乳品工业, 2024, 52(2):38-45.
ZHANG W J, MAO Y H, LI N, et al.Research advance on fermentation of goat milk and its health beneficial effects[J].China Dairy Industry, 2024, 52(2):38-45.
[25] 赵斐然, 张紫怡, 魏冠棉, 等.传统发酵豆制品中血管紧张素转换酶抑制四肽的构效关系研究[J].食品与发酵工业, 2025, 51(11):216-226.
ZHAO F R, ZHANG Z Y, WEI G M, et al.Structure-activity relationship of angiotensin converting enzyme inhibitor tetrapeptides in traditional fermented soybean products[J].Food and Fermentation Industries, 2025, 51(11):216-226.
[26] RUBAK Y T, NURAIDA L, ISWANTINI D, et al.Angiotensin-I-converting enzyme inhibitory peptides in milk fermented by indigenous lactic acid bacteria[J].Veterinary World, 2020, 13(2):345-353.
[27] 高楠, 李逸涵, 孙佳琦, 等.抗菌肽应用研究进展[J].农业生物技术学报, 2025, 33(6):1382-1397.
GAO N, LI Y H, SUN J Q, et al.Research progress on the application of antimicrobial peptides[J].Journal of Agricultural Biotechnology, 2025, 33(6):1382-1397.
[28] JI S Q, AN F Y, ZHANG T W, et al.Antimicrobial peptides:An alternative to traditional antibiotics[J].European Journal of Medicinal Chemistry, 2024, 265:116072.
[29] 王梦婷, 卢永忠.抗弧菌多肽的设计及筛选[J].生物技术, 2025, 35(2):164-168.
WANG M T, LU Y Z.Design and screening of anti-Vibrio peptides[J].Biotechnology, 2025, 35(2):164-168.
[30] 何容肖, 吴杨博, 张淑霞, 等.食品级重组乳酸乳球菌强组成型分泌猪肠道益生的pEGF-p40[J].畜牧兽医学报, 2025, 56(5):2243-2258.
HE R X, WU Y B, ZHANG S X, et al.Intestinal beneficial pEGF-p40 secreted by a food-grade recombinant Lactococcus lactis strong constitutive expression system[J].Acta Veterinaria et Zootechnica Sinica, 2025, 56(5):2243-2258.
[31] 蔡育诚, 吴灌原, 杨海冬, 等.益生菌在动物健康管理中的作用机制及其应用现状[J].中国畜牧兽医, 2025, 52(5):2101-2114.
CAI Y C, WU G Y, YANG H D, et al.Mechanisms and current applications of probiotics in animal health management[J].China Animal Husbandry & Veterinary Medicine, 2025, 52(5):2101-2114.
[32] JI H F, LI M, HAN X, et al.Lactobacilli-mediated regulation of the microbial-immune axis:A review of key mechanisms, influencing factors, and application prospects[J].Foods, 2025, 14(10):1763.
[33] 朱一, 武俊瑞, 纪帅奇, 等.乳源活性肽在功能性食品中的应用[J].中国乳品工业, 2024, 52(10):47-51;63.
ZHU Y, WU J R, JI S Q, et al.Progress on the application of milk derived active peptides in functional foods[J].China Dairy Industry, 2024, 52(10):47-51;63.
[34] YANG B, ZHENG F L, STANTON C, et al.Lactobacillus reuteri FYNLJ109L1 attenuating metabolic syndrome in mice via gut microbiota modulation and alleviating inflammation[J].Foods, 2021, 10(9):2081.
[35] 阮昕, 汪慎燚, 徐恰, 等.乳源免疫调节肽通过泛素-蛋白酶体途径抑制卵巢癌耐药性及其机制研究[J].安徽医科大学学报, 2018, 53(7):989-993.
RUAN X, WANG S Y, XU Q, et al.Immunomodulating peptide inhibits the drug resistance of ovarian cancer cell through the ubiquitin-proteasome pathway[J].Acta Universitatis Medicinalis Anhui, 2018, 53(7):989-993.
[36] IRAM D, KINDARLE U A, SANSI M S, et al.Peptidomics-based identification of an antimicrobial peptide derived from goat milk fermented by Lactobacillus rhamnosus (C25)[J].Journal of Food Biochemistry, 2022, 46(12):e14450.
[37] 杨动听, 王晔洋, 杨选, 等.食品呈味肽的呈味机制及计算机辅助分析研究进展[J].食品工业科技, 2024, 45(13):378-388.
YANG D T, WANG Y Y, YANG X, et al.Progress on the tasting mechanism and computer aided analysis of food taste-modulating peptides[J].Science and Technology of Food Industry, 2024, 45(13):378-388.
[38] AN F Y, LI M, ZHAO Y, et al.Metatranscriptome-based investigation of flavor-producing core microbiota in different fermentation stages of dajiang, a traditional fermented soybean paste of Northeast China[J].Food Chemistry, 2021, 343:128509.
[39] FAN Y H, GAN R J, ZHANG Z Y, et al.Flavor effect, application status, and research trend of umami peptides based on microbial fermentation in food[J].Food Microbiology, 2025, 130:104769.
[40] XIAO M Y, HUANG T, XU Y Z, et al.Metatranscriptomics reveals the gene functions and metabolic properties of the major microbial community during Chinese Sichuan Paocai fermentation[J].Food Microbiology, 2021, 98:103573.
[41] 石琳, 贾玮, 张荣, 等.酸奶滋味特征感知、形成过程与分析评价方法研究进展[J].食品工业科技, 2025, 46(9):445-455.
SHI L, JIA W, ZHANG R, et al.Progress of yoghurt taste characteristics perception, formation process and analysis and evaluation methods[J].Science and Technology of Food Industry, 2025, 46(9):445-455.
[42] AMORIM F G, COITINHO L B, DIAS A T, et al.Identification of new bioactive peptides from Kefir milk through proteopeptidomics:Bioprospection of antihypertensive molecules[J].Food Chemistry, 2019, 282:109-119.
[43] HELAL A, TAGLIAZUCCHI D.Peptidomics profile, bioactive peptides identification and biological activities of six different cheese varieties[J].Biology, 2023, 12(1):78.
[44] KAYACAN ØAKMAKOĞLU S, DERE S, BEKI·ROĞLU H, et al.Production of bioactive peptides during yogurt fermentation, their extraction and functional characterization[J].Food Bioscience, 2024, 61:104805.
[45] HU Y, LING Y X, QIN Z Y, et al.Isolation, identification, and synergistic mechanism of a novel antimicrobial peptide and phenolic compound from fermented walnut meal and their application in Rosa roxbughii Tratt spoilage fungus[J].Food Chemistry, 2024, 433:137333.
[46] YANG J, ZHAO P P, WANG Q Q, et al.Peptidomics-inspired discovery and activity evaluation of antioxidant peptides in multiple strains mixed fermentation of Porphyra yezoensis[J].Food Chemistry, 2024, 455:139779.
[47] HARYANI Y, ABDUL HALID N, GOH S G, et al.Efficient metabolic pathway modification in various strains of lactic acid bacteria using CRISPR/Cas9 system for elevated synthesis of antimicrobial compounds[J].Journal of Biotechnology, 2024, 395:53-63.
[48] LIU Z Y, HU R, HUANG L J, et al.Lactic acid bacteria with weak post-acidification potential applied for low-salt Paocai fermentation:A perspective from screening to molecular mechanism[J].LWT, 2024, 206:116531.
[49] MARULO S, DE CARO S, NITRIDE C, et al.Bioactive peptides released by lactic acid bacteria fermented pistachio beverages[J].Food Bioscience, 2024, 59:103988.
[50] ZHANG X, ZHENG Y R, LIU Z M, et al.Insights into characteristic metabolites and potential bioactive peptides profiles of fresh cheese fermented with three novel probiotics based metabolomics and peptidomics[J].Food Chemistry:X, 2024, 21:101147.
[51] ZHANG X D, DE LA FUENTE-NUNEZ C, WANG J.Artificial intelligence accelerates efficient mining of functional peptides[J].Life Medicine, 2023, 2(2):lnad005.
[52] JIN H, QUAN K Y, YOU L J, et al.A genomic compendium of cultivated food-derived lactic acid bacteria unveils their contributions to human health[J].Science Bulletin, 2025, 70(11):1761-1765.
[53] 汤传根, 王璟, 张烁, 等.功能肽合成和挖掘策略研究进展[J].合成生物学, 2025, 6(2):461-478.
TANG C G,WANG J, ZHANG S, et al.Advances in synthesis and mining strategies for functional peptides[J].Synthetic Biology Journal, 25, 6(2):461-478.
[54] CHANG J R, WANG H T, SU W T, et al.Artificial intelligence in food bioactive peptides screening:Recent advances and future prospects[J].Trends in Food Science & Technology, 2025, 156:104845.
[55] HABIB H M, ISMAIL R, AGAMI M, et al.Exploring the impact of bioactive peptides from fermented milk proteins:A review with emphasis on health implications and artificial intelligence integration[J].Food Chemistry, 2025, 481:144047.
[56] SHI H Y, ZHANG S L.Accurate prediction of anti-hypertensive peptides based on convolutional neural network and gated recurrent unit[J].Interdisciplinary Sciences:Computational Life Sciences, 2022, 14(4):879-894.
[57] SZYMCZAK P, SZCZUREK E.Artificial intelligence-driven antimicrobial peptide discovery[J].Current Opinion in Structural Biology, 2023, 83:102733.
[58] CHARIZANI E, DUSHKU E, KYRITSI M, et al.Predicting the immunomodulatory activity of probiotic lactic acid bacteria using supervised machine learning in a Cornu aspersum snail model[J].Fish & Shellfish Immunology, 2024, 152:109788.
[59] SUN T J, BU H L, YAN X, et al.LABAMPsGCN:A framework for identifying lactic acid bacteria antimicrobial peptides based on graph convolutional neural network[J].Frontiers in Genetics, 2022, 13:1062576.
[60] YUAN J M, MA D L, YANG Y T, et al.A review and prospects:Multi-omics and artificial intelligence-based approaches to understanding the effects of lactic acid bacteria and yeast interactions on fermented foods[J].Innovative Food Science & Emerging Technologies, 2025, 99:103874.
[61] CARPI F M, COMAN M M, SILVI S, et al.Comprehensive pan-genome analysis of Lactiplantibacillus plantarum complete genomes[J].Journal of Applied Microbiology, 2022, 132(1):592-604.
[62] GOH Y J, BARRANGOU R, KLAENHAMMER T R.In vivo transcriptome of Lactobacillus acidophilus and colonization impact on murine host intestinal gene expression[J].MBio, 2021, 12(1):e03 399-20.
[63] BALLARD J, WANG Z X, LI W R, et al.Deep learning-based approaches for multi-omics data integration and analysis[J].BioData Mining, 2024, 17(1):38.
[64] AHMED Z, WAN S B, ZHANG F, et al.Artificial intelligence for omics data analysis[J].BMC Methods, 2024, 1(1):4.
[65] HASHEMI S, VOSOUGH P, TAGHIZADEH S, et al.Therapeutic peptide development revolutionized:Harnessing the power of artificial intelligence for drug discovery[J].Heliyon, 2024, 10(22):e40265.
[66] CHICCO D, HEIDER D, FACCHIANO A.Editorial:Artificial intelligence bioinformatics:Development and application of tools for omics and inter-omics studies[J].Frontiers in Genetics, 2020, 11:309.
