妊娠期缺铁性贫血是常见的妊娠并发症,严重影响母婴健康。该研究旨在建立妊娠期缺铁性贫血大鼠模型,探讨阿胶低聚肽的改善作用及其潜在机制。通过饲喂低铁饲料建立妊娠期缺铁性贫血大鼠模型,将其分为6组:模型对照组、常规铁剂对照组、3个阿胶低聚肽干预组(低、中、高剂量)和1个联合干预组(常规铁剂+低剂量阿胶低聚肽),观察大鼠血常规指标、血清铁代谢相关指标以及微量元素水平、肝功能、肾功能、炎症和氧化应激相关指标、妊娠结局指标的变化。结果显示,阿胶低聚肽干预及联合干预可有效提升妊娠期缺铁性大鼠血红蛋白水平进而改善贫血,作用机制可能与调节铁代谢并减轻炎症发生有关。研究表明,阿胶低聚肽对妊娠期缺铁性贫血具有明确的改善功效,最优剂量为300 mg/kg阿胶低聚肽联合5.43 mg/kg硫酸亚铁,为膳食干预该疾病提供了新的思路和实验依据。
Iron deficiency anemia (IDA) is a prevalent complication during pregnancy, posing significant risks to maternal and fetal health.This study established a rat model of gestational IDA and investigated the therapeutic effects and underlying mechanisms of donkey-hide gelatin oligopeptides (DGOP).A low-iron diet successfully induced gestational IDA in rats.The animals were divided into six groups:model control, conventional iron supplement control, three DGOP intervention groups (low, medium, and high doses), and one combination group (conventional iron plus low-dose DGOP).Comprehensive measurements included blood routine parameters, serum iron metabolism markers, trace element levels, liver and kidney function, inflammatory and oxidative stress indicators, and pregnancy outcomes.Results demonstrated that DGOP interventions, particularly at medium and high doses, and the combination treatment significantly increased hemoglobin levels and improved anemia.These treatments also regulated key iron metabolism indicators and reduced pro-inflammatory cytokine levels.The study observed no significant effects on liver or kidney function or oxidative stress markers.DGOP exhibits significant efficacy in ameliorating gestational IDA, with its mechanism related to improved iron metabolism and reduced inflammation.These findings identify 300 mg/kg donkey-hide gelatin oligopeptides combined with 5.43 mg/kg ferrous sulfate as the optimal dosage for treating gestational iron deficiency anemia.The study supports donkey-hide gelatin oligopeptides’ potential as a dietary intervention for managing IDA during pregnancy.
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