Abstract: Iron is an essential trace element for the human body and is widely involved in basic biological processes such as oxygen transport and electron transport. Iron intake requires a strict adjustment mechanism to ensure the body's iron homeostasis, and maintaining the body's iron homeostasis is mainly achieved through fine regulation of intestinal iron absorption. Iron is widely involved in the functional regulation of specific immune systems such as immunocompetent cells and their cytokines and non-specific immune systems such as the phagocyte complement system. Intestinal microbes are closely related to the regulation of body iron homeostasis and affect the body's immune system function. Iron deficiency can cause significant changes in the balance and diversity of intestinal flora which could potentially affect intestinal immunity. This article reviews the effects of iron homeostasis, iron deficiency on intestinal flora and immunity, and the development of new iron supplements. It is proposed that iron may be used as a class of “de-biotics” to affect the balance of intestinal flora. New iron supplements development should focus on the overall impact of the host and intestinal flora, and provide new ideas for the development of new iron supplements so as to prevent and intervene with iron deficiency-related diseases.
管玲娟,曹丛丛,屠飘涵,等. 缺铁对肠道免疫功能的影响及新型补铁剂的研究进展[J]. 食品与发酵工业, 2020, 46(19): 264-270.
GUAN Lingjuan,CAO Congcong,TU Piaohan,et al. Research progress of the effect of iron deficiency on intestinal immune function and new iron supplements[J]. Food and Fermentation Industries, 2020, 46(19): 264-270.
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