The allergenicity reduction effect of bioprocessing technology on main allergens in aquatic products
XIAO Ye1,2,3, YE Jingqin1,2,3, YAN Jun1,2, SHI Wenzheng1,2, LU Ying1,2,3*
1(College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China) 2(Shanghai Engineering Research Center of Aquatic Product Processing & Preservation, Shanghai 201306, China) 3(Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation,Ministry of Agriculture, Shanghai 201306, China)
Abstract: In recent years, with the increasing consumption of aquatic products, the related allergic incidence rises year by year. Common allergy symptoms include skin itching, abdominal pain and diarrhea, etc., and severe cases will be life-threatening. The article reviewed the bioprocessing technologies such as enzyme modification, fermentation, and genetic improvement, as well as their advantages and disadvantages. And it also summarized the research status and reduction mechanism of applying biological processing technology on reducing the allergenicity of aquatic products allergenic proteins which to provide theoretical guidance for the use of biological processing technology to develop low-allergenic aquatic processed food.
SCHEURER S, TODA M, VIETHS S.What makes an allergen?[J].Clinical and Experimental Allergy, 2015, 45(7):1 150-1 161.
[2]
CARRARD A, RIZZUTI D, SOKOLLIK C.Update on food allergy[J].Allergy, 2015, 70(12):1 511-1 520.
[3]
PERKIN J E.Update on food allergy research[J].Allergies and Adverse Reactions, 1994, 9(3):22-32.
[4]
THONG B Y H, CHENG Y K, LEONG K P, et al.Immediate food hypersensitivity among adults attending a clinical immunology/allergy centre in Singapore[J].Singapore Medical Journal, 2007, 48(3):236-240.
[5]
SCOTT H, SICHERER, HUGH A, et al.Food allergy:a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management[J].Journal of Allergy and Clinical Immunology, 2018, 141(1):41-58.
[6]
BESLER M, STEINHART H, PASCHKE A.Stability of food allergens and allergenicity of processed foods[J].Journal of Chromatography B, 2001, 756(1-2):207-228.
[7]
MOU H, GAO M X, ZHAO J, et al.Influence of gamma irradiation and heat treatment on the immunogenicity of five epitopes of pen a1[J].Food Science and Technology Research, 2014, 20(5):955-960.
[8]
刘光明, 余惠琳, 黄秀秀, 等.加工处理方式对蟹类原肌球蛋白的消化稳定性和过敏原性的影响[J].中国食品学报, 2011, 11(4):14-22.LIU G M, YU H L, HUANG X X, et al.Effects of processing methods on digestibility and allergenicity of crab tropomyosin[J].Journal of Chinese Institute of Food Science and Technology, 2011, 11(4):14-22.
[9]
PATRICK G, STEFAN V, ANDREA W, et al.Maillard reaction and enzymatic browning affect the allergenicity of pru av 1, the major allergen from cherry (prunus avium)[J].Agricultural and Food Chemistry, 2004(12):4 002-4 007.
[10]
徐静, 李一尘, 徐君怡, 等.食品加工对过敏原活性的影响[J].食品安全质量检测学报, 2012, 3(4):259-263.XU J, LI Y C, XU J Y, et al.Effects of processing on food allergens[J].Journal of Food Safety and Quality, 2012, 3(4):259-263.
[11]
BRENNA O, POMPEI C, ORTOLANI C, et al.Technological processes to decrease the allergenicity of peach juice and nectar[J].Journal of Agricultural and Food Chemistry, 2000, 48(2):493-497.
[12]
吴海明, 胡志和, 王丽娟.凡纳滨对虾主要过敏原鉴定及酶法消减技术的研究[J].食品科学, 2010, 31(17):272-276.WU H M, HU Z H, WANG L J, et al.Identification and enzymatic elimination of major allergens in litopenaeus vannamei[J].Food Science, 2010, 31(17):272-276.
[13]
FU L L, SONG J Y, WANG C, et al.Bifidobacterium infantis potentially alleviates shrimp tropomyosin-induced allergy by tolerogenic dendritic cell-dependent induction of regulatory t cells and alterations in gut microbiota[J].Frontiers in Immunology, 2017, 8:1 536.
[14]
WAI C Y Y, LEUNG N Y H, HO M H K, et al.Immunization with hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity[J].PLOS One, 2014, 9(11):111 649.
[15]
李风铃, 李沂光, 孙天乐, 等.水产品中主要过敏原的研究与展望[J].中国渔业质量与标准, 2018, 8(1):16-23.LI F L, LI Y G, SON T L, et al.Research advances and perspectives on allergens of aquatic products[J].Chinese Fishery Quality and Standards, 2018, 8(1):16-23.
[16]
张永霞, 杨阳, 蔡秋凤, 等.水产食物过敏原及其抗原表位的研究进展[J].中国渔业质量与标准, 2015, 5(5):1-8.ZHANG Y X, YANG Y, CAI Q F, et al.The research of seafood allergens and its epitopes[J].Chinese Fishery Quality and Standards, 2015, 5(5):1-8.
[17]
UNTERSMAYR E, SZALAI K, RIEMER A B, et al.Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen[J].Molecular Immunology, 2006, 43(9):1 454-1 461.
[18]
农小献, 宾石玉, 蒙涛, 等.小清蛋白研究进展[J].生物技术通讯, 2011, 22(6):887-891.NONG X X, BIN S Y, MENG T, et al.Research progress of parvalbumins[J].Letters in Biotechnology, 2011, 22(6):887-891.
[19]
YANG Y, CAO M J, ALCOCER M, et al.Mapping and characterization of antigenic epitopes of arginine kinase of Scylla paramamosain[J].Molecular Immunology, 2015, 65(2):310-320.
[20]
AYUSO R, SÁNCHEZ-GARCIA S, PASCAL M, et al.Is epitope recognition of shrimp allergens useful to predict clinical reactivity?[J].Clinical & Experimental Allergy, 2012, 42(2):293-304.
[21]
ZHENG L N, LIN H, PAWAR R, et al.Mapping IgE binding epitopes of major shrimp (Penaeus monodon) allergen with immunoinformatics tools[J].Food and Chemical Toxicology, 2011, 49(11):2 954-2 960.
[22]
孙超, 王彦波, 傅玲琳.甲壳类水产品主要过敏原致敏反应及免疫调控机制[J].中国食品学报, 2014, 14(7):185-191.SON C, WANG Y B, FU L L.Molecular mechanisms on sensitization and immune regulation of major allergens from crustaceans[J].Journal of Chinese Institute of Food Science and Technology, 2014, 14(7):185-191.
[23]
毛海燕. 拟穴青蟹精氨酸激酶的过敏性及其构效关系的初步研究[D].厦门:集美大学, 2013.MAO H Y.Preliminary study on the allergenicity and structure-activity relationship of arginine kinase from Scylla paramamosain[D].Xiamen:Jimei University, 2013.
[24]
CHEN H L, CAO M J, CAI Q F, et al.Purification and characterisation of sarcoplasmic calcium-binding protein, a novel allergen of red swamp crayfish (Procambarus clarkii)[J].Food Chemistry, 2013, 139(1-4):213-223.
[25]
AYUSO R, GRISHINA G, BARDINA L, et al.Myosin light chain is a novel shrimp allergen, Lit v 3[J].Journal of Allergy and Clinical Immunology, 2008, 122(4):795-802.
[26]
WNUK W, JAUREGUI-ADELL J.Polymorphism in high-affinity calcium-binding proteins from crustacean sarcoplasm[J].European Journal of Biochemistry, 1983, 131(1):177-182.
[27]
宋益银, 林蕾, 苏秀榕, 等.锯缘青蟹(Scylla serrata)特异性过敏原的研究[J].海洋与湖沼, 2009, 40(1):62-67.SONG Y Y, LIN L, SU X R, et al.The specific allergens in crab Scylla serrata[J].Oceanologia Et Limnologia Sinica, 2009, 40(1):62-67.
[28]
BAUERMEISTER K, WANGORSCH A, GAROFFO L P, et al.Generation of a comprehensive panel of crustacean allergens from the North Sea Shrimp Crangon crangon[J].Molecular Immunology, 2011, 48(15-16):1 983-1 992.
[29]
HAMADA Y, NAGASHIMA Y, KAZUO S.Identification of collagen as a new fish allergen[J].Bioscience Biotechnology and Biochemistry, 2001, 65(2):285-291.
[30]
LIU R, KRISHNAN H B, XUE W T, et al.Characterization of allergens isolated from the freshwater fish blunt snout bream (Megalobrama amblycephala)[J].Journal of Agricultural and Food Chemistry, 2011, 59(1):458-463.
[31]
FEI D X, LIU Q M, CHEN F, et al.Assessment of the sensitizing capacity and allergenicity of enzymatic cross-linked arginine kinase, the crab allergen[J].Molecular Nutrition and Food Research, 2016, 60(7):1 707-1 718.
[32]
MEJRHIT N, AZDAD O, CHDA A, et al.Evaluation of the sensitivity of Moroccans to shrimp tropomyosin and effect of heating and enzymatic treatments[J].Food and Agricultural Immunology, 2017(1):1-12.
[33]
TIAN S, MA J, AHMED I, et al.Effect of tyrosinase-catalyzed crosslinking on the structure and allergenicity of turbot parvalbumin mediated by caffeic acid[J].Journal of the Science of Food and Agriculture, 2019,99(7):3 504-3 508.
[34]
王学丽, 李娅茹, 王梦梦,等.体外模拟胃液消化对虾中主要过敏原原肌球蛋白抗原表位的影响[J].中国免疫学杂志, 2019, 35(19):2 319-2 325.WANG X L, LI Y R, WANG M M, et al.Effects of in vitro simulated gastric fluid digestion on epitopes of major allergen tropomyosin in shrimp[J].Chinese Journal of Immunology, 2019, 35(19):2 319-2 325.
[35]
谢秀玲, 李欣, 高金燕, 等.非热加工对食物过敏原影响的研究进展[J].食品科学, 2013, 34(17):344-349.XIE X L, LI X, GAO J Y, et al.A review of studies on the effect of non-thermal processing on food allergens[J].Food Science, 2013, 34(17):344-349.
[36]
阿木尔吉日嘎拉. 乳酸菌的免疫调节作用研究[D].呼和浩特:内蒙古农业大学, 2006.AR M E.The modulating effect of lactic acid bacteria on immune system[D].Hohhot:Inner Mongolia Agricultural University, 2006.
[37]
NERMES M, SALMINEN S, ISOLAURI E.Is there a role for probiotics in the prevention or treatment of food allergy?[J].Current Allergy and Asthma Reports, 2013, 13(6):622-630.
[38]
高卿, 李振兴, 米娜莎, 等.海鲈鱼鱼肉发酵过程中小清蛋白IgE结合能力的变化[J].食品科学, 2017, 38(22):88-94.GAO Q, LI Z X, MI N S, et al.Effect of fermentation on Ig E binding ability of sea bass (Lateolabrax japonicus) parvalbumin[J].Food Science, 2017, 38(22):88-94.
[39]
傅玲琳, 赵淑淑, 王彦波.具有缓解对虾原肌球蛋白致敏性乳酸菌的筛选及其免疫调节作用[J].中国食品学报, 2018, 18(2):15-21.FU L L, ZHAO S S, WANG Y B.Screening and immunomodulatory effects of lactic acid bacterial strains with relieving sensitization of shrimp tropomyosin[J].Journal of Chinese Institute of Food Science and Technology, 2018, 18(2):15-21.
[40]
史晓磊. 基因工程在降低植物性食品致敏性中应用[J].粮食与油脂, 2009(9):4-6.SHI X L.Application of genetic engineering in reduction of the allergenicity of plant food[J].Food And Oil, 2009(9):4-6.
[41]
REESE G, VIEBRANZ J, LEONG-KEE S M, et al.Reduced allergenic potency of vr9-1, a mutant of the major shrimp allergen pen a 1 (tropomyosin)[J].Journal of Immunology, 2005, 175(12):8 354-8 364.
[42]
蔺海鑫. pH及糖基化处理对菲律宾蛤仔原肌球蛋白性质的影响[D].青岛:中国海洋大学, 2015.LIN H X.Effect of pH shifts and glycation on lgE-binding capacity and conformational structure of tropomyosin from short-neck clam (Ruditapes philippinarum)[D].Qingdao:Ocean University of China, 2015.
[43]
刘光明, 沈苑, 曹敏杰, 等.虾类过敏原的识别、纯化和检测技术研究[J].中国食品学报, 2008, 8(6):142-148.LIU G M, SHENG Y, CAO M J, et al.Study on the identification, purification and detection technique of shrimp allergen[J].Journal of Chinese Institute of Food Science and Technology, 2008, 8(6):142-148.
[44]
刘光明, 曹敏杰, 袁静静, 等.酶水解海蟹加工下脚料制备调味品原料[J].中国食品学报, 2009, 9(6):83-89.LIU G M, CAO M J, YUAN J J, et al.Preparation of raw condiment with enzyme hydrolysate of the processing leftover from marine crab[J].Journal of Chinese Institute of Food Science and Technology, 2009, 9(6):83-89.
[45]
李振兴, 高卿, 米娜莎, 等.一种利用微生物降低鱼类过敏原活性的方法:中国, CN106722382A[P].2017-05-31.LI Z X, GAO Q, MI N S, et al.A method that uses microorganisms to reduce fish allergen activity:China, CN106722382A[P].2017-05-31.
[46]
FU L L, PENG J X, ZHAO S S, et al.Lactic acid bacteria-specific induction of CD4+Foxp3+T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling[J].Scientific Reports, 2017, 7(1):1 987.
[47]
李振兴, 袁方舟, 米娜莎, 等.一种降低刀额新对虾过敏原原肌球蛋白的方法:中国, CN106072071B[P].2019-10-01.LI Z X, YUAN F Z, MI N S, et al.A method to reduce the amount of myosin of the new shrimp allergen:China, CN106072071B[P].2019-10-01.
[48]
胡晓利, 布冠好.高压均质与酶法联合改性对大豆蛋白抗原性及结构的影响[J].河南工业大学学报(自然科学版), 2018, 39(6):29-35.HU X L, BU G H.Effects of combination of high pressure homogenization and enzymatic and modification on the antigenicity and structure of soybean protein isolates[J].Journal of Henan University of Technology(Natural Science Edition), 2018, 39(6):29-35.