Abstract: Microbial fermentation is the main way of industrial production of lipase. Thermophilic lipase derived from wild bacteria could not meet the requirement of thermal stability of lipase for industrial production. The application of microbial lipase in industry has gradually become the focus of bioengineering research, and the construction of high-yield and well-characterized enzyme-producing strains is the focus of current research. Therefore, in this paper, the recent research progress on the thermophilic lipase involving the producing bacteria and enzymatic characterization, the heterologous expression system, structural modification, isolation, purification and immobilization and so on were reviewed, and the outstanding achievements were mainly described, so as to provide theoretical and methodological references for the research in this direction.
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2021, Vol. 47 
