Advances on process regulation of Ganoderma triterpene acids production by liquid fermentation
LI Li1,2, YANG Yunli1,2, YANG Xiaofan3, HE Wei3, YUAN Kai3, ZHU Weiyu3, PENG Chao3, HE Yifan1,2, DONG Yinmao1,2, ZHOU Weiqiang3*
1(College of chemistry and materials engineering of Beijing Technolgoy & Business University, Beijing 100048,China) 2(Beijing Key Lab of Plant Resource Research and Development, Beijing 100048,China) 3(Nutrition & Health Research Institute, COFCO Corporation, Beijing 102209,China)
Abstract: Ganoderma triterpene acids (GTAs) are one of the main characteristic components of Ganoderma lucidum to exert its immunoregulatory function. The production methods of GTAs include fruit body extraction, sporoderm-broken spores and liquid submerged fermentation. The liquid fermentation of G. lucidum is viewed as a research hotspot globally due to its advantages, including short cycle, easy and precise control of fermentation conditions and feasible industrial production. In this paper, the regulation of GTAs liquid submerged fermentation is reviewed in two aspects, fermentation conditions and exogenous elicitors, which can provide a reference for fermentation technology to increase the production of GTAs, and prospect for related research.
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