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食品与发酵工业  2021, Vol. 47 Issue (7): 301-306    DOI: 10.13995/j.cnki.11-1802/ts.025355
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耿雪营, 郭藏, 米生权*, 张艳贞, 郭俊霞, 陈文
(北京联合大学 健康与环境学院,北京,100023)
Plasma glucose regulating activity of tannin
GENG Xueying, GUO Cang, MI Shengquan*, ZHANG Yanzhen, GUO Junxia, CHEN Wen
(College of Health and Environment, Beijing Union University, Beijing 100023, China)
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摘要 高血糖是多种慢性病的共同危险因素,调节血糖也是慢性病防治的重要手段。单宁作为一种天然活性物质,广泛存在于植物中,具有良好的血糖调节活性。该文简述了植物单宁的分类、提取方法及具有的生物学活性功能,重点梳理了植物单宁的血糖调节活性作用机制。植物单宁血糖调节活性作用机制可分为:抑制α-葡萄糖苷酶和α-淀粉酶的活性,影响食物中碳水化合物分解,延缓碳水化合物的吸收率;促进葡萄糖转运蛋白4的表达,提高体内葡萄糖转运能力,改善胰岛素抵抗;通过激活酪氨酸激酶活性,影响酪氨酸蛋白磷酸化水平,促进细胞对葡萄糖摄取能力等。但目前抑制糖异生、促进糖元酵解方面研究较为匮乏,这可能成为单宁血糖调节活性研究的一个新切入点。
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关键词:  单宁  血糖  α-葡萄糖苷酶  α-淀粉酶  葡萄糖转运蛋白4  酪氨酸蛋白    
Abstract: Hyperglycemia is a common risk factor of many chronic diseases, plasma glucose regulating is also an important method for preventing and treating chronic diseases.As a natural active substance, tannins widely exist in plants and have an outstanding activity on plasma glucose regulating.The classification, extraction and bioactive functions of plant tannins were briefly described, focusing on the mechanism of plasma sugar regulating the activity of plant tannins.Plant tannins can delay carbohydrate absorption by inhibiting the activities of α-glucosidase and α-amylase, improved insulin resistance by promoting the expression of glucose transporter 4 and improving the transport capacity of glucose, affect the phosphorylation level of tyrosine protein to promote the ability of cells to uptake glucose by activating tyrosine kinase activity.However, there were few reports on the inhibition of gluconeogenesis and the promotion of glycolysis, indicating a breakthrough point in the study of blood glucose regulation activity of tannin.
Key words:  tannin    plasma glucose    α-glucosidase    α-amylase    glucose transporter 4    tyrosine protein
收稿日期:  2020-08-13      修回日期:  2020-09-27           出版日期:  2021-04-15      发布日期:  2021-05-20      期的出版日期:  2021-04-15
基金资助: 国家重点研发计划项目(2018YFC1311400);北京联合大学人才强校优选计划项目(BPHR2017CZ03);北京联合大学研究生教育教学研究与改革项目(JY2019Y006)
作者简介:  硕士研究生(米生权副教授为通讯作者,
耿雪营,郭藏,米生权,等. 单宁的血糖调节活性功能研究进展[J]. 食品与发酵工业, 2021, 47(7): 301-306.
GENG Xueying,GUO Cang,MI Shengquan,et al. Plasma glucose regulating activity of tannin[J]. Food and Fermentation Industries, 2021, 47(7): 301-306.
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