Please wait a minute...
 
 
食品与发酵工业  2021, Vol. 47 Issue (8): 290-296    DOI: 10.13995/j.cnki.11-1802/ts.025641
  综述与专题评论 本期目录 | 过刊浏览 | 高级检索 |
植物多糖在Ⅱ型糖尿病降血糖作用方面的研究进展
周雯1,2, 庄蕾1, 3, 吴森1, 3*
1(青海省高原家畜遗传资源保护与创新利用重点实验室(青海大学),青海 西宁,810016)
2(青海大学 农牧学院,青海 西宁,810016)
3(青海大学 畜牧兽医科学院,青海 西宁,810016)
Research progress of plant polysaccharides in hypoglycemic effect of type 2 diabetes mellitus
ZHOU Wen1,2, ZHUANG Lei1,3, WU Sen1,3*
1(Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining 810016, China)
2(College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China)
3(Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China)
下载:  HTML   PDF (1536KB) 
输出:  BibTeX | EndNote (RIS)      
摘要 Ⅱ型糖尿病(type 2 diabetes mellitus,T2DM)是一种复杂的代谢紊乱性疾病,发病机理复杂,会引起多种并发症,严重威胁人类健康。传统治疗药物在降血糖的同时会带来许多副作用,而一些具有降血糖作用的植物多糖因其来源广泛、毒副作用小,引起人们关注。越来越多的研究证明,一些来源于可食用天然植物的多糖具有很好的降血糖活性。该文在简述T2DM发病因素的同时,综述了一些植物多糖在T2DM降血糖方面的研究进展,以期为治疗T2DM的植物多糖产品研发、T2DM的日常预防及相关治疗提供理论参考。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
周雯
庄蕾
吴森
关键词:  植物多糖  Ⅱ型糖尿病  发病机理  降血糖    
Abstract: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder disease. The pathogenesis of T2DM is complex and have various complications. It seriously threatened human health. Traditional therapeutic drugs bring many side effects while lowering blood glucose. However, some plant polysaccharides with lower blood sugar effects have attracted people's attention because of their wide sources and low side effects. A growing number of studies have proved that some polysaccharides derived from edible natural plant have significant hypoglycemic activity. This review describes the pathogenesis T2DM briefly and elaborates the research progress of the hypoglycemic effect of plant polysaccharides in T2DM, in order to provide theoretical reference for the research and development of plant polysaccharide products in the treatment of T2DM, daily prevention and related treatment of T2DM.
Key words:  plant polysaccharides    type 2 diabetes mellitus    pathogenesis    hypoglycemia
               出版日期:  2021-04-25      发布日期:  2021-05-20      期的出版日期:  2021-04-25
基金资助: 青海省科学技术厅自然科学基金项目(2020-ZJ-947Q);牧科院基本科研业务费自主选题项目(MKY-2019-05);青海省“高端创新人才千人计划”(引进拔尖人才)
作者简介:  硕士研究生(吴森副研究员为通讯作者,E-mail:wusenkgdsss@hotmail.com)
引用本文:    
周雯,庄蕾,吴森. 植物多糖在Ⅱ型糖尿病降血糖作用方面的研究进展[J]. 食品与发酵工业, 2021, 47(8): 290-296.
ZHOU Wen,ZHUANG Lei,WU Sen. Research progress of plant polysaccharides in hypoglycemic effect of type 2 diabetes mellitus[J]. Food and Fermentation Industries, 2021, 47(8): 290-296.
链接本文:  
http://sf1970.cnif.cn/CN/10.13995/j.cnki.11-1802/ts.025641  或          http://sf1970.cnif.cn/CN/Y2021/V47/I8/290
[1] 汪磊. 刺梨多糖的分离纯化、降血糖作用及其对肠道微生态的影响[D].广州:华南理工大学, 2019.WANG L.Isolation, purification and hypoglycemic activity of polysaccharides from Rosa roxburghii Tratt fruit and their effect on gut microflora[D].Guangzhou:South China University of Technology, 2019.
[2] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志, 2018, 38(4):292-344.Chinese Diabetes Society.Guidelines for the prevention and control of type 2 diabetes in China (2017 edition)[J].Chinese Journal of Practical Internal Medicine, 2018, 38(4):292-344.
[3] CHO N H, SHAW J E, KARURANGA S, et al.IDF Diabetes Atlas:Global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Research and Clinical Practice, 2018, 138:271-281.
[4] CHEN H, NIE Q, HU J, et al.Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on type 2 diabetic rats[J].Journal of Agricultural and Food Chemistry, 2019, 67(18):5 278-5 288.
[5] ZHOU M G, WANG H D, ZENG X Y, et al.Mortality, morbidity, and risk factors in China and its provinces, 1990-2017:A systematic analysis for the global burden of disease study 2017[J].The Lancet, 2019, 394(10 204):1 145-1 158.
[6] 孟庆龙, 金莎, 刘雅婧, 等.植物多糖药理功效研究进展[J].食品工业科技, 2020, 41(11):335-341.MENG Q L, JIN S, LIU Y J, et al.Research progress in pharmacological efficacy of plant polysaccharides[J].Food Industry Technology, 2020, 41(11):335-341.
[7] 肖瑞希, 陈华国, 周欣.植物多糖降血糖作用及机制研究进展[J].食品科学, 2019, 40(11):254-260.XIAO R X, CHEN H G, ZHOU X.Recent progress in understanding of hypoglycemic effect and underlying mechanism of plant polysaccharides[J].Food Science, 2019, 40(11):254-260.
[8] DURRUTY P,MARIA S,SANHUEZA L.Pathogenesis of Type 2 Diabetes Mellitus[M].London:IntechOpen, 2019:1-18.
[9] 张旭东, 张雷.胰岛素抵抗与2型糖尿病[J].解剖科学进展, 2008,14(1):92-95.ZHANG X D, ZHANG L.Relationship of type 2 diabetes mellitus with insulin resistance[J].Progress of Anatomical Sciences, 2008,14(1):92-95.
[10] ZHOU Y D, ZHANG E M, CHRISTINE B, et al.Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway[J].Human Molecular Genetics, 2012, 21(1):196-207.
[11] MALONE J I, HANSEN B C.Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?[J].Pediatric Diabetes, 2019, 20(1):5-9.
[12] 杨永青, 杨明庆.肥胖诱发胰岛素抵抗的炎性机制[J].中国生物化学与分子生物学报, 2012, 28(8):692-699.YANG Y Q, YANG M Q.Inflammatory mechanisms in obesity-induced insulin resistance[J].Chinese Journal of Biochemistry and Molecular Biology, 2012, 28(8):692-699.
[13] 彭伟霞, 俞茂华.老年糖尿病[J].国外医学(内科学分册), 2004(7):296-299.PENG W X, YU M H.Senile diabetes[J].International Journal of Internal Medicine, 2004(7):296-299.
[14] SCHMITZ N, DESCHENES S S, BURNS R J, et al.Depression and risk of type 2 diabetes:The potential role of metabolic factors[J].Molecular Psychiatry, 2016, 21(12):1 726-1 732.
[15] LINA R, RYTAS O.Adding salt to meals as a risk factor of type 2 diabetes mellitus:A case-control study[J].Nutrients, 2017, 9(1):67.
[16] 丁静云, 梁真.葡萄糖毒性对胰岛β细胞功能影响的研究进展[J].深圳中西医结合杂志, 2015, 25(17):197-199.DING J Y, LIANG Z.Recent studies of glucotoxicity of pancreas islet β cell function[J].Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2015, 25(17):197-199.
[17] 周和超, 黄贵心.脂毒性与胰岛素抵抗的相关研究进展[J].国外医学(老年医学分册), 2007(1):28-32.ZHOU H C, HUANG G X.Research progress on the relationship between lipotoxicity and insulin resistance[J].International Journal of Geriatrics, 2007(1):28-32.
[18] LI Y, LI S, HE S L, et al. Structural analysis and antidiabetic activity study of three acidic-type polysaccharides from Crepis crocea (Lam.) Babc[J].Natural Product Research, 2020(22):1-6.
[19] 丁婷, 杨建华, 路新卫, 等.桃胶粗多糖对糖尿病小鼠免疫调节和血糖影响初探[J].食品工业, 2009, 30(6):7-9.DING T, YANG J H, LU X W, et al.Investigation on the effect of blood-glucose level and immunity in diabetic mice by taking peach resin[J].The Food Industry, 2009, 30(6):7-9.
[20] 唐思梦, 杨泽民, 陈伟强, 等.黄芪多糖保护胰岛β细胞改善大鼠2型糖尿病[J].第二军医大学学报, 2017, 38(4):482-487.TANG S M, YANG Z M,CHEN W Q, et al.Astragalus polysaccharide improves type 2 diabetes mellitus in rats by protecting islet β cells[J].Academic Journal of Second Military Medical University, 2017, 38(4):482-487.
[21] YANG S, QU Y, ZHANG H, et al.Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms[J].Food & Function, 2020, 11(1):424-434.
[22] SHAO T, YUAN P, ZHU L, et al.Carbon nanoparticles inhibit A-glucosidase activity and induce a hypoglycemic effect in diabetic mice[J].Molecules, 2019, 24(18):3 257-3 266.
[23] ZHANG Y, WANG H, ZHANG L, et al.Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress[J].International Journal of Biological Macromolecules, 2020, 145:944-949.
[24] 刘振宇, 邹圣灿.燕麦β-葡聚糖复合物改善II型糖尿病大鼠症状及作用机制研究[J].轻工科技, 2020, 36(5):107-110.LIU Z Y, ZOU S C.Oat β-glucan complex improves the symptoms of type 2 diabetes mellitus rats and its mechanism of action[J].Light Industry Science and Technology, 2020, 36(5):107-110.
[25] SU J, LIU X, LI H, et al.Hypoglycaemic effect and mechanism of an RG-II type polysaccharide purified from Aconitum coreanum in diet-induced obese mice[J].International Journal of Biological Macromolecules, 2020, 149:359-370.
[26] YUAN Y, ZHOU J, ZHENG Y, et al.Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice[J].Biomed Pharmacother, 2020, 127:110 182.
[27] 李爱云, 杨京, 张昕宇, 等.小檗碱治疗2型糖尿病降血糖机制的研究进展[J].中国实验方剂学杂志, 2019, 25(22):219-226.LI A Y, YANG J, ZHANG X Y, et al.Research progress on effect of hypoglycemic mechanism of berberine in treatment of type 2 diabetes mellitus[J].Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(22):219-226.
[28] 高攀攀, 李盼盼, 蔡晓萌.黄芪多糖通过PI3K/Akt途径抑制小鼠胰岛βTC-6细胞凋亡的机制研究[J].营养学报, 2019, 41(3):265-269.GAO P P, LI P P, CAI X M.Inhibition of apoptosis though PI3K/Akt pathway by βTC-6 cells astragalus polysaccharides in pancreatic[J].Acta Nutrimenta Sinica, 2019, 41(3):265-269.
[29] 杨光. 多花黄精多糖对GLP-1分泌与表达的调节及其分子机制研究[D].合肥:合肥工业大学, 2018.YANG G.The effect of Polygonatum cyrtonema Hua polysaccharides (PCP) on the expression and secretion of GLP-1 and its molecular mechanism[D].Hefei:Hefei University of Technology, 2018.
[30] 李跃松, 王静, 潘凌峰, 等.胰岛素抵抗与血尿酸、空腹血糖和血脂代谢关系的分析[J].现代预防医学, 2012, 39(22):5 951-5 953;5 959.LI Y S, WANG J, PAN L F, et al.Study on the association among insulin resistance, serum uric acid, fasting blood glucose and lipids metabolism[J].Modern Preventive Medicine, 2012, 39(22):5 951-5 953;5 959.
[31] CHEN Y, LIU D, WANG D, et al. Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice[J].Food and Chemical Toxicology, 2019, 126:295-302.
[32] SHAN X, LIU X, HAO J, et al. In vitro and in vivo hypoglycemic effects of brown algal fucoidans[J].Int J Biol Macromol, 2016, 82:249-255.
[33] TASLIMI P, GULCIN I.Antidiabetic potential:In vitro inhibition effects of some natural phenolic compounds on α-glycosidase and α-amylase enzymes[J].Journal of Biochemical and Molecular Toxicology, 2017, 31(10):e21 956.
[34] DAUB C D, MABATE B, MALGAS S, et al.Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, alpha-glucosidase[J].International Journal of Biological Macromolecules, 2020, 151:412-420.
[35] HUANG Z, LIN F, ZHU X, et al.An exopolysaccharide from Lactobacillus plantarum H31 in pickled cabbage inhibits pancreas alpha-amylase and regulating metabolic markers in HepG2 cells by AMPK/PI3K/Akt pathway[J].International Journal of Biological Macromolecules, 2020, 143:775-784.
[36] 路国兵, 任春久, 崔为正, 等.桑叶多糖MLPⅡ对糖尿病模型大鼠肝脏胰岛素抵抗的改善作用[J].蚕业科学, 2012, 38(1):116-121.LU G B, REN C J, CUI W Z, et al.Improvement effect of polysaccharide MLPⅡ from mulberry leaves on hepatic insulin resistance in diabetic model rat[J].Science of Sericulture, 2012, 38(1):116-121.
[37] QIAO Z, DU X, ZHUANG W, et al.Schisandra chinensis acidic polysaccharide improves the insulin resistance in type 2 diabetic rats by inhibiting inflammation[J].Journal of Medicinal Food, 2020, 23(4):358-366.
[38] 王云威, 王景雪.铁皮石斛多糖对2型糖尿病小鼠降糖降脂的作用[J].食品科学, 2020,41(21):127-132.WANG Y W, WANG J X.Effect of Dendrobium officinale polysaccharide on hypoglycemic and lipid-lowering effects in type 2 diabetic mice[J].Food Science, 2020,41(21):127-132.
[39] CHEN J, LI L, ZHOU X, et al. Preliminary characterization and antioxidant and hypoglycemic activities in vivo of polysaccharides from Huidouba[J].Food & Function, 2018, 9(12):6 337-6 348.
[40] 宋紫临, 吴丽丽, 秦灵灵, 等.PI3K/AKT信号通路与糖尿病的研究进展[J].世界科学技术-中医药现代化, 2019, 21(6):1 264-1 269.SONG Z L, WU L L, QIN L L, et al.Research progress of PI3K/AKT signaling pathway and diabetes mellitus[J].Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2019, 21(6):1 264-1 269.
[41] CAI W D, DING Z C, WANG Y Y, et al.Hypoglycemic benefit and potential mechanism of a polysaccharide from Hericium erinaceus in streptozotoxin-induced diabetic rats[J].Process Biochemistry, 2020, 88:180-188.
[42] PETI W, PAGE R.Molecular basis of MAP kinase regulation[J].Protein Science, 2013, 22(12):1 698-1 710.
[43] 向阳, 杨晨晨, 韩曾娇, 等.刺糖多糖对小鼠腹腔巨噬细胞核转录因子、丝裂原活化蛋白激酶及氨基末端激酶信号通路相关基因和蛋白表达的影响[J].新乡医学院学报, 2019, 36(8):706-714.XIANG Y, YANG C C, HAN C J, et al.Effect of polysaccharide from Saccharum alhagi on the expression of nuclear transcription factor-κB, mitogen-activated protein kinase and c-Jun N-terminal kinase signal pathway related genes and proteins in peritoneal macrophages of mice[J].Journal of Xinxiang Medical University, 2019, 36(8):706-714.
[44] SHUKLA R, BANERJEE S, TRIPATHI Y B.Pueraria tuberosa extract inhibits iNOS and IL-6 through suppression of PKC-alpha and NF-κB pathway in diabetes-induced nephropathy[J].The Journal of pharmacy and pharmacology, 2018, 70(8):1 102-1 112.
[45] LI X, ZHAO Z, KUANG P, et al. Regulation of lipid metabolism in diabetic rats by Arctium lappa L.polysaccharide through the PKC/NF-kappaB pathway[J].International Journal of Biological Macromolecules, 2019, 136:115-122.
[46] 王琪. 太子参多糖通过Nrf2分子途径改善肝脏胰岛素抵抗机制研究[D].西宁:青海大学, 2015.WANG Q.Mechanism of Radix pseudostellariae polysaccharide through the Nrf2 pathway to improve hepatic insulin resistance[D].Xining:Qinghai University, 2015.
[47] 贺云, 杨丽霞, 邱连利.从肠道微生态角度探讨2型糖尿病的发病机制以及治疗措施[J].中国实验方剂学杂志, 2020, 26(15):229-234.HE Y, YANG L X, QIU L L.Discussion on pathogenesis and treatment of type 2 diabetes from perspective of intestinal microecology[J].Chinese Journal of Experimental Traditional Medical Formulae, 2020, 26(15):229-234.
[48] SHANG X L, PAN L C, TANG Y, et al.1H NMR-based metabonomics of the hypoglycemic effect of polysaccharides from Cordyceps militaris on streptozotocin-induced diabetes in mice[J].Natural Product Research, 2020, 34(10):1 366-1 372.
[49] WANG L, LI C, HUANG Q, et al.Polysaccharide from Rosa roxburghii Tratt fruit attenuates hyperglycemia and hyperlipidemia and regulates colon microbiota in diabetic db/db mice[J].Journal of Agricultural and Food Chemistry, 2020, 68(1):147-159.
[1] 符群, 郐滨, 钟明旭, 吴小杰. 超声波辅助酶解法提取北虫草菌素及其降血糖活性研究[J]. 食品与发酵工业, 2021, 47(9): 120-127.
[2] 孟洋, 卢红梅, 杨双全, 章之柱, 陈莉, 刘兵, 王利萍. 铁皮石斛复配花茶制作工艺及其功能性研究[J]. 食品与发酵工业, 2021, 47(8): 170-179.
[3] 刘婷, 周欣, 赵超, 龚小见, 陈华国. 植物多糖对肾损伤干预效果及作用机制研究进展[J]. 食品与发酵工业, 2021, 47(7): 269-277.
[4] 彭明芳, 李培骏, 单杨, 陈玉秋, 杨岱峻, 雷丽嫦, 黄芝辉, 余孔新. 比较基因组揭示广西酸菜乳杆菌碳水化合物活性酶谱[J]. 食品与发酵工业, 2021, 47(4): 68-73.
[5] 刘韫滔, 黄伟民, 李诚, 刘爱平, 王体强, 唐婷婷. 木姜叶柯全发酵茶的活性成分及其降血糖活性研究[J]. 食品与发酵工业, 2020, 46(20): 53-60.
[6] 曾铁鑫, 姚志仁, 李豫, 朱开梅, 兰圆圆, 顾生玖. 巴戟天不同极性萃取相的抗氧化及降血糖活性[J]. 食品与发酵工业, 2020, 46(19): 192-196.
[7] 张世奇, 唐兰兰, 孙劲毅, 杨娟, 惠永海. 辣椒素降糖作用及其机制研究进展[J]. 食品与发酵工业, 2020, 46(13): 262-269.
[8] 田文慧, 杨永晶, 吴云, 陈薇. 树莓果肉多糖在1型糖尿病大鼠中的免疫调节和抗氧化活性研究[J]. 食品与发酵工业, 2020, 46(12): 102-108.
[9] 司倩, 焦婷, 杨树荣, 孙珊珊, 王刚, 赵建新, 张灏, 陈卫. 两歧双歧杆菌缓解Ⅱ型糖尿病的效果差异及机制分析[J]. 食品与发酵工业, 2019, 45(22): 12-19.
[10] 曾桥, 韦承伯, 夏飞, 李祥. 响应面法优化超声波辅助提取杜仲叶茯砖茶绿原酸及其体外降血糖抗氧化活性[J]. 食品与发酵工业, 2018, 44(9): 204-211.
[11] 贾福怀,许璐云,王彩霞,袁媛,熊菲菲,雷蕾. 降糖类保健食品配方及功效成分研究现状与展望[J]. 食品与发酵工业, 2017, 43(10): 282-287.
[12] 李丹丹, 宋烨, 吴茂玉, 朱风涛, 于滨, 马晓燕,. 植物多糖的水解及水解物结构的研究进展[J]. 食品与发酵工业, 2013, 39(07): 165-170.
[13] 赵国华,曾凯红,阚健全,陈宗道. 羧甲基豆渣膳食纤维的制备及其性能研究[J]. 食品与发酵工业, 2003, 29(7): 88-.
[14] 张拥军,王兰州,姚惠源. 南瓜中降血糖活性成分的提取及其功能性质的研究[J]. 食品与发酵工业, 2002, 28(6): 32-.
No Suggested Reading articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
版权所有 © 《食品与发酵工业》编辑部
地址:北京朝阳区酒仙桥中路24号院6号楼111室
本系统由北京玛格泰克科技发展有限公司设计开发  技术支持:support@magtech.com.cn