Abstract: With the severe problem of population aging, the number of patients with neurodegenerative diseases is increasing annually, which brings troubles to public health and leads to more social problems. Bovine milk-derived neuroprotective peptides attenuate symptoms of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease by inhibiting neuro-inflammation and β-amyloid plaque deposition caused by oxidative damage and cause no side effects. Recent researches related to milk-derived neuroprotective peptides are mainly efficacy evaluation, but there is still few relevant and comprehensive research focus on their mechanism in vivo. This review focuses on bovine milk-derived bioactive peptides and summarizes researches about their structure-activity relationships, neuroprotective efficacy and mechanism, which confirms the unique value of those bioactive peptides in neuroprotection.
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2022, Vol. 48 
