采用低温酸法提取云南鲷鱼皮酸溶性胶原蛋白（ASC），对ASC的氨基酸组成、亚基组成、结构特征、热稳定性以及溶解性等理化性质进行了研究，为云南鲷鱼皮的综合利用提供了理论依据。研究表明，ASC的主要氨基酸为甘氨酸、脯氨酸和丙氨酸，酪氨酸、蛋氨酸和半胱氨酸含量较低，脯氨酸的羟化率为35.47%；SDS-PAGE电泳图谱表明ASC主要由α₁、α₂以及β链组成，符合I型胶原蛋白的特征；ASC的最大紫外吸收波长为230 nm；红外光谱和X-射线图谱表明ASC分子排列规则紧凑，具有完整的三螺旋结构；差示热量扫描显示ASC的热变性温度分别为82.1和222.3℃，表明ASC的热稳定性较好；扫描电镜显示ASC分子呈三维的多片状结构，分布均匀，适合用作食品、药品和化妆品的载体和生物医学的基料；在pH值小于4或NaCl浓度低于4%（w/v）时，ASC具有良好的溶解性。

The acid soluble collagen (ASC) of skin of Yunnan bream was extracted, and the amino acids composition, subunit composition, structural characteristics, thermal stability and solubility of which were investigated. Research showed that ASC was rich in Gly, Pro, Ala, low in Tyr, Met, Cys, and the hydroxylation rate of proline was 35.47%; SDS-PAGE revealed that ASC was mainly composed of α₁、α₂ and β chains, which was in accordance with the structural features of type I collagen; The maximum UV absorption wavelength was at 230 nm; XRD and FTIR showed that the molecule of ASC was closely and regularly arranged and the helical structure of which was maintained; DSC showed the thermal denaturation temperature of ASC were 86.5 and 226.2℃; SEM showed that ASC was uniformly distributed and had a multi-layered micro structure, which was suitable to be used as carrier in food, medicine and cosmetics industry, and base material in biomedicine; the solubility of ASC was relatively high under acidic (pH<4) and low NaCl concentration (<4% (w/v)) conditions. This paper provided a theoretical basis for the comprehensive utilization of skin of Yunnan bream.