天然存在的霉菌毒素的暴露会影响人体健康。环境中的许多真菌毒素会对组蛋白修饰状态产生影响，这种表观遗传改变在疾病的发生与发展中往往发挥重要作用。近年来，真菌毒素在表观遗传学层面的致毒机制也已成为研究热点。然而截止目前，专注于真菌毒素致毒的组蛋白修饰方面的综述仍然缺乏。文章综述了黄曲霉毒素(AFB1)、脱氧雪腐镰刀菌烯醇(DON)、赭曲霉毒素(OTA)、伏马毒素(FB1)、T-2毒素等多种真菌毒素对组蛋白修饰影响的最新研究进展及其可能的作用机制，为进一步揭示环境毒素污染对人体健康的影响及食品安全风险评估提供了参考依据。

The exposure of naturally occurring mycotoxins affects human health and plays a vital role in cancer initiation and progression.Increasing evidences indicated that exposure to mycotoxin was associated with many diseases.Many mycotoxins have been proved to alter the histone modification status，such epigenetic changes are related to the occurrence and development of many disease.Recently, the mode of mycotoxins epigenetic research has been advanced in research hotspots.However, there is still no study on histone modification of mycotoxin-induced toxicity.In this paper, the effects of several mycotoxins including aflatoxin (AFB1), deoxynivalenol (DON), ochratoxin (OTA), fumonisim B1 (FB1) and T-2 toxin on histone modification，and the involved pathogenic mechanisms were reviewed.This may be helpful for revealing effects of mycotoxin contamination on human healthy and provide a reference for assessment of food safety risk.