为提高酿酒酵母合成番茄红素能力，从底盘宿主种类、功能基因拷贝数、启动子种类等方面综合考虑，优化番茄红素合成途径与酿酒酵母底盘宿主间的适配性。结果表明，以酿酒酵母CEN.PK2-1C为宿主，采用多拷贝质粒pRS42K为载体，使用组成型启动子控制番茄红素合成途径表达时，番茄红素合成水平显著提高，产量比初始菌株提高了约70倍，达到3.62 mg/L，表明改善外源代谢途径与酵母底盘间的适配性是提高目标产物合成的有效手段。

To improve the production of lycopene biosynthesis in Saccharomyces cerevisiae, the adaptation between lycopene biosynthesis pathway and normal metabolism of the chassis was optimized through investigating the species of chassis host, the copy number of functional gene and the type of promoter. The results proved that lycopene could be efficiently produced when using Saccharomyces CEN.PK2-1C as chassis, coupling with multi-copy plasmid pRS42K, and employing constitutive promoter to control the expression of lycopene biosynthesis pathway. Comparing with the initial engineered strain, yield of lycopene was increased by about 70 times, reaching 3.62 mg/L, suggesting that improving the adaptation between exogenous metabolic pathway and yeast host was an effective approach to enhance the synthesis of target products.