从中国工业微生物菌种资源库优选的38株乳酸菌中，筛选得到1株γ-氨基丁酸(γ-aminobutyric acid，GABA)产量较高的植物乳杆菌CICC 6238。通过紫外诱变育种，CICC 6238的GABA产量提高至(1.196±0.033) g/L，是原菌株的2.33倍。与商业益生菌嗜酸乳杆菌NCFM和鼠李糖乳杆菌HN001相比，CICC 6238对胆盐、人工胃液和人工肠液具有良好的耐受性。CICC 6238耐胆盐存活率为(36.90±1.63)%，显著高于NCFM[(15.16±1.73)%]；在人工胃液消化3 h的存活率为(84.05±1.87)%，显著高于HN001[(61.97±2.45)%]；在人工肠液消化6 h后的存活率为(61.50±1.94)%，略低于HN001[(77.44±3.08)%]和NCFM[(79.42±2.08)%]。CICC 6238对4种肠道致病菌尤其是福氏志贺氏菌具有明显的抑制作用，抑菌圈可达(28.31±0.27) mm。CICC 6238既能高产GABA，又具有潜在的益生特性，可作为功能益生菌，应用于未来功能性食品及保健食品的研究开发。

Lactobacillus plantarum CICC 6238 was screened out for γ-aminobutyric acid (GABA) production from 38 lactic acid bacteria deposited in the China Center of Industrial Culture Collection (CICC). The high-yield GABA strains were obtained by ultraviolet mutagenesis，and its production of GABA was (1.196±0.033) g/L，which was 2.33 times as much as original strain. CICC 6238 was studied extensively for its high tolerance to simulated gastric, intestine juices and bile salts with commercial probiotic strains (Lactobacillus acidophilus NCFM and Lactobacillus rhamnosus HN001) as positive control. After incubation in bile salt environment, the survival rate of CICC 6238 was (36.90±1.63)% significantly higher than NCFM [(15.16±1.73)%]. After digestion in artificial gastric juice for 3 hours, the survival rate of CICC6238 was (84.05±1.87)%, which was remarkably greater than that of HN001 [(61.97±2.45)%]. After incubation in artificial intestine juices for 6 hours, the survival rate of CICC 6238 was (61.50±1.94)%, which was slightly lower than that of HN001 [(77.44±3.08)%] and NCFM [(79.42±2.08)%]. And CICC 6238 also could inhibit the growth of four kinds of intestinal tract pathogenic bacteria, especially Shigella flexneri with the inhibition zone reaching to (28.31±0.27) mm. The results suggested that CICC 6238 has high-yield of GABA and potential probiotic properties, which showed good potential for application in functional foods and health-related products.