食品与发酵工业 >

2019 , Vol. 45 >Issue 16: 286 - 292

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.020861

综述与专题评论

电渗析技术在氨基酸分离中的应用进展与趋势

  • 熊能 ,
  • 陈涛 ,
  • 孙自立 ,
  • 柳志强
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  • 1 (生物有机合成浙江省重点实验室(浙江工业大学),浙江 杭州,310014)
    2 (教育部生物转化与生物净化重点实验室(浙江工业大学),浙江 杭州,310014)
    3 (手性生物制造国家地方联合工程研究中心(浙江工业大学),浙江 杭州,310014)
博士,讲师(柳志强为通讯作者,E-mail:microliu@zjut.edu.cn)

收稿日期: 2019-04-16

  网络出版日期: 2019-09-23

基金资助

浙江省公益技术研究计划(LGG19B060003);中国博士后科学基金(2017M621969)

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Research progress and trends of electrodialysis in amino acid separation

  • XIONG Neng ,
  • CHEN Tao ,
  • SUN Zili ,
  • LIU Zhiqiang
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  • 1 (Key Laboratory of Bioorganic Synthesis of Zhejiang Province (Zhejiang University of Technology), Hangzhou 310014, China)
    2 (Engineering Research Center of Bioconversion and Biopurification (Zhejiang University of Technology), Hangzhou 310014, China)
    3 (National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals (Zhejiang University of Technology), Hangzhou 310014, China)

Received date: 2019-04-16

  Online published: 2019-09-23

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摘要

电渗析是新兴的先进分离技术,最近在氨基酸分离领域逐渐得到应用。它具有分离效率高,选择性好,操作简单,节约用水等优点,发展前景广阔。该文首先将电渗析与其他氨基酸分离技术进行对比,指出了其优势与限制,随后分析了膜材料与操作条件等对氨基酸分离效率的影响,以及制约电渗析技术发展最大的问题-膜污染,并介绍了应对膜污染的数种解决方案。发现根据具体分离的氨基酸,选用具有较好选择性的膜材料及匹配的pH等操作条件,即能够获得较理想的产品收率。而膜污染的防治可以依靠对原料液进行净化和预处理、执行电极倒换和设备清洗等操作,以及对膜材料进行改性制备抗污染膜来实现。该文综述了当前电渗析技术在氨基酸分离中的应用情况,期望为氨基酸分离领域的研究者提供理论支持和参考,并加速电渗析技术在氨基酸工业中的产业化进程。

关键词： 电渗析; 氨基酸; 生物分离; 膜分离; 膜污染

本文引用格式

熊能 , 陈涛 , 孙自立 , 柳志强 . 电渗析技术在氨基酸分离中的应用进展与趋势[J]. 食品与发酵工业, 2019 , 45(16) : 286 -292 . DOI: 10.13995/j.cnki.11-1802/ts.020861

Abstract

Electrodialysis is an emerging technique that has recently applied in the field of amino acid separation. It has the advantages of high separation efficiency, good selectivity, simple operation and reduced water consumption, and has broad prospects for development. This paper first compares electrodialysis with other techniques in amino acid separation, points out its advantages and limitations, then analyses the influence of membrane materials and operation conditions on the separation efficiency, as well as the biggest problem that limits the development of electrodialysis: membrane fouling. Several solutions for membrane fouling are also introduced. It is found that depending on the separated amino acid, selecting the membrane with specific selectivity, as well as the matching operation conditions such as pH is crucial. A favorable product yield can therefore be achieved. The prevention and control of membrane fouling can be achieved by purifying and pretreating the feed solution, performing electrode switching and equipment cleaning, and modifying the membrane material to prepare anti-fouling membrane. In this paper, the current application of electrodialysis in amino acid separation has been reviewed. It is expected to provide theoretical support and reference for researchers in the field of amino acid separation, and accelerate the industrialization of electrodialysis in the amino acid industry.

Key words： electrodialysis; amino acid; bioseparation; membrane separation; membrane fouling

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