作为丝孢类真菌的代表菌株,标准菌株ATCC 16404被列入包括《美国药典》在内的各类标准中。2008年,Jan Houseknecht等人通过表型结合基因型的多相鉴定技术,确认该菌株为巴西曲霉(Aspergillus brasiliensis)。2010年新版《美国药典》和世界微生物菌种数据中心(WDCM)编制的《培养基相关参考菌株目录》采纳了该菌株新的分类学描述。这一变化会导致各国对标准中涉及的黑曲霉标准菌株重新进行分类学鉴定,并对内部相关的SOP进行修改。文中详细介绍了该菌株的历史、基本特征、在标准中的应用情况以及新的多相分类鉴定研究进展。

As a representative of filamentous fungi,Aspergillus niger ATCC 16404 was cited in various standards including USP.It was reclassified as A.brasiliensis through polyphasic taxonomic approach including phenotypic and genotypic analysis by Jan Houseknecht in 2008.The new taxonomy description was accepted by USP(2010)and Reference Strain Catalogue for Performance Testing Culture Media by WDCM.This change will lead to reclassification of A.niger referred in various standards and modification relevant internal SOP.The history,characters,application in criterion and recent polyphasic taxonomic were introduced.