研究了采用多种膜分离技术生产霉酚酸的工艺。通过陶瓷膜、超滤膜、纳滤膜的组合试验,对膜组件进行了筛选,得到了优化的试验方案。通过工艺优化,霉酚酸收率提高至65%～70%,有机溶剂用量减少70%,溶剂损耗减少80%以上,大幅度降低了生产成本,简化了生产工艺,提高了产品的收率和质量,使工艺过程更安全,环保。

Several membrane separation techniques,including ceramic membrane,ultrafiltration membrane and nanofiltration membrane,have been studied on mycophenolic acid production.The optimized conditions have been obtained.This method simplifies the mycophenolic acid production process,enhances product purity and yield,and promotes the benefit of environmental safety.The yield is increased to 65%~70%,the input organic solvent is reduced by 70%,and the usage of organic solvent was decreased by 80%,so the production cost was significantly reduced.The method also presents great application value under the current policies which advocate resource conservation,green production,and sustainable development.