建立了一种罐头食品中的BADGE(bisphenol A diglycidyl ether,双酚A-二环氧甘油醚)、NOGE(novolacglycidyl ether,酚醛清漆甘油醚)及其衍生物含量的超高效液相色谱-串联质谱检测法。前处理包括正己烷/丙酮微波辅助萃取,Varain-PS-DVB固相萃取柱净化等。样品经BEH C18色谱柱(100 mm×2.1 mm,1.7μm)分离,以乙腈和0.2%甲酸水为流动相,进行梯度洗脱,在API 4000-QTRAP质谱仪电喷雾正离子、多反应监测(MRM)模式下进行检测。分析物检出限达到0.010 2 ng/g到0.197 2 ng/g,三水平加标回收率在65.7%～99.1%。

An ultra-performance liquid chromatography with tandem mass spectrometry method for determination of bisphenol A diglycidyl ether(BADGE),novolac glycidyl ether(NOGE) and its derivatives from canned food has been developed.The proposed method includes microwave-assisted extraction followed by puri?cation by solid phase extraction(SPE).After separation by BEH C18(column 100 mm×2.1 mm,1.7 μm),the sample was detected by API 4000-QTRAP mass spectrometry under positive electrospray ionization mode,with acetonitrile and 0.2% aqueous formic acid as mobile phase.The detection limits were 0.010 2~0.197 2 ng/g,and recoveries at three different concentrations ranged from 65.7% to 99.1%.This method was successfully applied to canned fish and meat,the highest total contents of 3~6 R-NOGE reached 209.03 mg/6 dm2.