研究了榆干离褶伞(Lyophyllum ulmarium,L.u)发酵液的体外溶栓作用和降血脂作用。将血凝块与L.u发酵液37℃恒温孵育,测定血凝块溶解时间;观察给予L.u发酵液后对小鼠体内出、凝血时间的影响;采用高脂血症动物模型,观察L.u发酵液对血脂水平的影响。结果显示,L.u发酵液明显延长凝血时间及出血时间,明显降低高脂血症小鼠总甘油三酯和总胆固醇含量。可以证明,L.u发酵液具有溶栓作用,其机制可能与其抗凝作用和降血脂作用有关。

To observe the fibrinolytic function of fermentation broth of Lyophyllum ulmarium(L.u) in vitro and its hypolipidemic effect in vivo.Methods: The activity of L.u was measured by clot liquefaction time and the effect of L.u on bleeding time and coagulation time were observed after L.u treatment.The hyperlipidemic animal model was established,and then the effect of L.u on blood lipids was evaluated.Results: L.u prolonged the coagulation time and bleeding time,reduced the serum levels of total triglycerides and total cholesterols in hyperlipidemic animals.Conclusions: L.u has the fibrinolytic function.The effects may be due to its anticoagulant and hypolipidemic function.