ε-聚-L-赖氨酸作为微生物合成的赖氨酸聚合物,具有良好的抑菌活性和生物相容性,在食品和医药等领域的需求量日增。然而因受微生物胞内代谢调控的制约,其合成量低。基于前体赖氨酸代谢途径的遗传改造,以及有效的发酵控制策略,已在一定程度上提高了ε-聚-L-赖氨酸的产率。对ε-聚-L-赖氨酸合成酶及降解酶的分子结构研究和产生菌遗传转化体系的构建,有望进一步提升ε-聚-L-赖氨酸的品质和产量。

As a microbial biosynthetic lysine polymer,ε-poly-L-lysine exhibits good antimicrobial and biocompatible activities. It has been an increasing demand for ε-poly-L-lysine in industrial applications such as food and medicine. However,the productivity in ε-poly-L-lysine producing strain is low due to the intracellular regulation. The genetic modifications of the producer and the effective fermentation control have enhanced ε-poly-L-lysine productivity to some extent. The studies on the structures of synthetase and degrading enzyme for ε-poly-L-lysine on molecular level and the construction of gene delivery systems for its producer are expected to further improve the quality and the yield of ε-poly-L-lysine.