以海南产椰子的种皮油提取物(CEOE)为研究对象,探讨了其对蛋白质羰基氧化的抑制作用、过氧化氢的清除能力、过氧化氢诱导的人血清蛋白氧化损伤和羟自由基引发的DNA损伤的保护作用。结果表明:CEOE可有效抑制过氧化氢引发的蛋白质羰基和氢过氧化物的增多;且2.5 mg/mL的CEOE对过氧化氢的清除率已达49.81%;同时该提取物还可以修复羟自由基诱导的DNA损伤;是一种值得开发的抗氧化剂资源。

Coconut(Cocosnucifera L.) endocarp oil extract(CEOE) obtained from the coconut grown up in Hainan island were analyzed on its inhibiting effect on the oxidation of protein carbonyl,hydrogen peroxide scavenging activity,protective effect on hydrogen peroxide-induced oxidative damage to human serum albumin and hydroxyl radical-induced DNA damage.The results showed that CEOE could inhibit the increase of protein carbonyl and hydroperoxides content induced by hydrogen peroxide effectively,and its scavenging activity on hydrogen peroxide was 49.81%at 2.5 mg /mL;meanwhile,CEOE was able to repair the DNA damage induced by hydroxyl radical,which suggested that CEOE might be a new worthy exploiting source of natural antioxidants.