[1] SAUTER M, MOFFATT B, SAECHAO M C, et al.Methionine salvage and S-adenosylmethionine:Essential links between sulfur, ethylene and polyamine biosynthesis[J].Biochem,2013,451(2):145-154.
[2] 陈英军,张卓标,吕海龙.我国蛋氨酸生产现状及市场分析[J].精细与专用化学品, 2005,13(16):22-24.
CHEN Y J, ZHANG Z B, LYU H L.Domestic production situation of methionine and its market analysis[J].Fine and Specialty Chemicals, 2005, 13(16):22-24.
[3] 苏雪梅.食品级L-蛋氨酸的生产工艺[J].中国调味品,2019,44(9):141-143.
SU X M.Production process of feed-grade L-methionine[J].China Condiment, 2019, 44(9):141-143.
[4] 李爱平.几种新型药用氨基酸及衍生物的制备[D].南京:东南大学, 2005.
LI A P.Preparation of several new medicinal amino acids and their derivatives[D].Nanjing:Southeast University, 2005.
[5] SAGONG H Y, KIM K J.Structural insights into substrate specificity of cystathionine γ-synthase from Corynebacterium glutamicum[J].J Agric Food,2017,65(29):6 002-6 008.
[6] QIN T, HU X Q, HU J, et al.Metabolic engineering of Corynebacterium glutamicum strain ATCC13032 to produce L-methionine[J].Biotechnol Appl Biochem,2015,62(4):563-573.
[7] LI Y, CONG H, LIU B N, et al.Metabolic engineering of Corynebacterium glutamicum for methionine production by removing feedback inhibition and increasing NADPH level[J].Anton Leeuw Int J G,2016,109(9):1 185-1 197.
[8] 李莹.基于代谢工程选育谷氨酸棒状杆菌L-蛋氨酸高产菌[D].哈尔滨工业大学,2016.
LI Y.Breeding L-methionine over-producer by Corynebacterium glutamicum based on metabolic engineering[D].Harbin:Harbin Institute of Technology, 2016.
[9] HUANG J F, LIU Z Q, JIN L Q, et al.Metabolic engineering of Escherichia coli for microbial production of L-Methionine[J].Biotechnol Bioeng,2017,114(4):843-851.
[10] 李华.系统代谢工程改造大肠杆菌生产L-蛋氨酸[D].无锡:江南大学,2017.
LI H.Systematic metabolic engineering of Escherichia coli for L-methionine production[D].Wuxi:Jiangnan University, 2017.
[11] HUANG J F, SHEN Z Y, MAO Q L, et al.Systematic analysis of bottlenecks in a multi-branched and multilevel regulated pathway:The molecular fundamentals of methionine biosynthesis in Escherichia coli[J].Acs Synth Biol,2018,7(11):2 577-2 589.
[12] DISCHERT W, FIGGE R.Patent to metabolic explorer:Recombinant microorganism for the fermentative production of methionine[P].WO2013/190343(A1).2013-06-09.
[13] ZHOU H Y, WU W J, NIU K, et al.Enhanced L-methionine production by genetically engineered Escherichia coli through fermentation optimization[J].Biotech,2019,9(3):96.
[14] NIU K, XUY Y, WU WJ, et al.Effect of dissolved oxygen on L-methionine production from glycerol by Escherichia coli W3110BL using metabolic flux analysis method[J].J Ind Microbiol Biotechnol,2020,47(3):287-297.
[15] LI Y,Ai Y Q, ZhANG J Z, et al.A novel expression vector for Corynebacterium glutamicum with an auxotrophy complementation system[J].Plasmid,2020,107:102 476.
[16] PARK S D, LEE J Y, SIM S Y, et al.Characteristics of methionine production by an engineered Corynebacterium glutamicum strain[J].Metab Eng,2007,9(4):327-336.
[17] RUCKERT C.Sulfate reduction in microorganisms—recent advances and biotechnological applications[J].Curr Opin Microbiol,2016,33(5):140-146.
[18] JANDER G, JOSHI V.Recent progress in deciphering the biosynthesis of aspartate-derived amino acids in plants[J].Mol Plant,2010,3(1):54-65.
[19] NAKATANI T, OHTSU I, NONAKA G, et al.Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli[J].Microb Cell Fac,2012,11(1):62.
[20] CHEN Z G, ZHANG X, LI H, et al.The complete pathway of thiosulfate utilization in Saccharomyces cerevisiae[J].Appl Environ Microbiol,2018,84(22):1-15.
[21] 黄勤勤,王慧梅,梁玲等.定点突变及lysC、asdA串联表达对谷氨酸棒杆菌L-苏氨酸积累的影响[J].生物技术通报, 2019,35(2):93-100.
HUANG Q Q, WANG H M, LIANG L, et al.Effects of site-directed mutation of gene lysC and co-expression of asdA cluster on L-threonine accumulation in Corynebacterium glutamicum[J].Biotechnology Bulletin, 2019, 35(2):93-100.
[22] GANGULY S, SATAPATHY KB.Statistical optimization of culture conditions for L-Methionine production by Corynebacterium glutamicum X300[J].Journal of Theoretical & Computational Science,2017,4(1):1-7.
[23] 徐德雨,郑小梅,赵晶,等.谷氨酸棒杆菌天冬氨酸激酶G359D突变解除赖氨酸与苏氨酸协同抑制的研究[J].生物技术通报,2017,33(11):143-152.
XU D Y, ZHENG X M, ZHAO J, et al.Aspartate kinase G359D from Corynebacterium glutamicum relieves the synergistic inhibition of lysine and threonine[J].Biotechnology Bulletin, 2017, 33(11):143-152.
[24] DONG X, ZHAO Y, ZHAO J, et al.Characterization of aspartate kinase and homoserine dehydrogenase from Corynebacterium glutamicum IWJ001 and systematic investigation of L-isoleucine biosynthesis[J].J Ind Microbiol Biotechnol,2016,43(6):873-885.
[25] REINSCHEID D J, EIKMANNS B J, SAHM H.Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase[J].J Bacteriol,1991,173(10):3 228-3 230.
[26] USUDA Y, KURAHASHI O.Effects of deregulation of methionine biosynthesis on methionine excretion in Escherichia coli[J].Appl Environ Microbiol,2005,71(6):3 228-3 234.
[27] 郭谦,方芳,李江华,等.代谢工程改造蛋氨酸代谢途径构建高产L-蛋氨酸大肠杆菌[J].过程工程学报,2013,13(6):1 013-1 019.
GUO Q, FANG F, LI J H, et al.Metabolic engineering of methionine biosynthesis pathway for production of L-methionine by Escherichia coli[J].The Chinese Journal of Process Engineering, 2013, 13(6):1 013-1 019.
[28] MOCKEL B, PFEFFER W, MARX A, et al.Nucleotide sequences which code for the Met Y gene[P].US, 20020110878A1.2002-08-15.
[29] WEI L, WANG Q, XU N, et al.Metabolic engineering strategies for high-level production of O-Acetylhomoserine in Escherichia coli[J].ACS Synth Biol,2019,8(5):1 153-1 167.
[30] 吴婷婷.大肠杆菌dapA基因的敲除及其对蛋氨酸产量影响的研究[D].长春:吉林大学,2008.
WU T T.Study on L-methionine yield of E.coli with dapA gene deletion[D].Changchun:Jilin University,2008.
[31] 万方,陈民良,张斌,等.代谢工程改造微生物高产氨基酸的策略[J].中国生物工程杂志,2015,35(3):99-103.
WANG F, CHEN M L, ZHANG B, et al.Strategy of metabolic engineering microorganism for high yield amino acids[J].China Biotechnology, 2015, 35(3):99-103.
[32] RICARDO M A, MUNEHIRO T, PENELOPE S, et al.Identification of new ligands for the methionine biosynthesis transcriptional regulator (MetJ) by FAC-MS[J].J Mol Microbiol Biotechnol,2012,22(4):205-214.
[33] 闫海洋,林松毅,欧阳红生.大肠杆菌metJ的基因修饰对其蛋氨酸产量的影响[J].现代农业科技,2014(5):296-297;300.
NI H Y, LIN S Y, OUYANG H S, et al.Effect of gene modification in Escherichia coli metJ on its L-Met production[J]. Xian Dai NongYe Ke Ji, 2014(5):296-297.
[34] REY D A, NENTWICH S S, KOCH D J, et al.The McbR repressor modulated by the effector substance S-denosylhomocysteine controls directly the transcription of a regulon involved in sulphur metabolism of Corynebacterium glutamicum ATCC 13032[J].Mol Microbiol,2005,56(4):871-887.
[35] NAKAMORI S, KOBAYASHI S, NISHIMURA T, et al.Mechanism of L-methionine overproduction by Escherichia coli:The replacement of Ser-54 by Asn in the MetJ protein causes the derepression of L-methionine biosynthetic enzymes[J].Appl Microbiol Biotechnol,1999,52(2):179-185.
[36] MAXON M E, REDFIELD B, CAI X Y, et al.Regulation of methionine synthesis in Escherichia coli:Effect of the MetR protein on the expression of the metE and metR genes[J].Proc Natl Acad Sci USA,1989,86(1):85-89.
[37] 董迅衍,王小元.微生物生产L-苏氨酸的代谢工程研究进展[J].食品与生物技术学报,2016,35(12):1 233-1 240.
DONG X Y, WANG X Y.Advances in microbial metabolic engineering to increase L-Threonine production[J].Journal of Food Science and Biotechnology, 2016, 35(12):1 233-1 240.
[38] LIU Q, LIANG Y, ZHANG Y, et al.YjeH is a novel exporter of L-methionine and branched-chain amino acids in Escherichia coli[J].Appl Environ Microbiol,2015,81(22):7 753-7 766.
[39] MERLIN C, GARDINER G, DURAND S, et al.The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ) [J].J Bacteriol,2002,184(19):5 513-5 517.
[40] TRÖTSCHEL C, DEUTENBERG D, BATHE B, et al.Characterization of methionine export in Corynebacterium glutamicum[J].J Bacteriol,2005,187(11):3 786-3 794.
[41] LANGE C, MUSTAFI N, FRUNZKE J, et al.Lrp of Corynebacterium glutamicum controls expression of the brnFE operon encoding the export system for L-methionine and branched-chain amino acids[J].J Biotechnol,2011,158(4):231-241.
[42] KOPRIVOVA A, KOPRIVA S.Molecular mechanisms of regulation of sulfate assimilation:First steps on a long road[J].Front Plant Sci,2014,5:589.
[43] PILSYK S, PASZEWSKI A.Sulfate permeases-phylogenetic diversity of sulfate transport[J].Acta Biochim Pol,2009,56(3):375-384.
[44] AGUILAR-BARAJAS E, DÍAZ-PÉREZ C, RAMÍREZ-DÍAZ M I, et al.Bacterial transport of sulfate, molybdate, and related oxyanions[J].BioMetals,2011,24(4):687-707.
[45] 董伟.转运系统集成改造提升大肠杆菌胞外L-蛋氨酸积累[D].无锡:江南大学,2018.
DONG W.The effect of amino acid transporter system modification on extracellular L-methionine accumulation in Escherichia coli[D].Wuxi:Jiangnan University, 2018.
[46] LIU H, HOU Y, WANG Y, et al.Enhancement of sulfur conversion rate in the production of L-cysteine by engineered Escherichia coli[J].J Agri and Food Chem,2020,68(1):250-257.
[47] GUÉDON E, MARTIN-VERSTRATE.Cysteine metabolism and its regulation in bacteria[M].Springer-Verlag Berlin Heidelberg,2006:195-218.
[48] KRÕMER J O, WITTMANN C, SCHRÕDER H,et al.Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum[J].Metab Eng,2006,8(4):353-369.
[49] GEORGI T, RITTMANN D, WENDISCH V F.Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose:Roles of malic enzyme and fructose-1,6-bisphosphatase[J].Metab Eng, 2005,7(4):291-301.
[50] JUNKO O, RITSUKO K, SATOSHI M, et al.A novel gnd mutation leading to increased L-lysine production in Corynebacterium glutamicum[J].FEMS Microbiol Lett,2005,242(2):265-274.
[51] BECKER J, ZELDER O,Stefan H, et al.From zero to hero-design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production[J].Metab Eng,2011,13(2):159-168.
[52] BOMMAREDDY R R, ChEN Z, RAPPERT S, et al.A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase[J].Metab Eng,2014,25:30-37.
[53] 刘俊琦,于金龙,宋凤亮.北京棒杆菌AS1.299发酵生产蛋氨酸的营养条件优化[J].现代食品, 2018, 5(9):34-38;46.
LIU J Q, YU J L, SONG F L.Optimization of fermentation conditions for producing methionine by Corynebacterium AS 1.299[J].Modern Food, 2018, 5(9):34-38;46.
[54] LI Y, WEI H, WANG T, et al.Current status on metabolic engineering for the production of L-aspartate family amino acids and derivatives[J].Bioresource Technol, 2017, 245:1 588-1 602.
[55] 王宝瑄,袁学斌.蛋氨酸螯合物简易测定方法[J].饲料博览,2003(4):28-29.
WANG B X, YUAN X B.A simple method for the determination of methionine chelate[J].Feed Review, 2003(4):28-29.
[56] 刘强,黄应祥,王聪,等.蛋氨酸硒对西门塔尔牛瘤胃发酵及尿嘌呤衍生物的影响[J].中国生态农业学报,2009,17(1):110-114.
LIU Q, HUANG Y X, WANG C, et al.Effect of selenium methionine on rumen fermentation and purine derivatives in simmental steer[J].Chinese Journal of Eco-Agriculture, 2009, 17(1):110-114.
[57] KRAUSE R J, RIPP S L, SAUSEN P J, et al.Characterization of the methionine S-Oxidase activity of rat liver and kidney microsomes:Immunochemical and kinetic evidence for FMO3 being the major catalyst[J].Arch Biochem Biophy,1996,333(1):109-116.
[58] WANG F, LI S L, XIN J, et al.Effects of methionine hydroxy copper supplementation on lactation performance, nutrient digestibility, and blood biochemical parameters in lactating cows[J].J Dairy Sci,2012,95(10):5 813-5 820.
[59] BHARADWAJ A S, PATNAIK S, BROWDY C L,et al.Comparative evaluation of an inorganic and a commercial chelated copper source in Pacific white shrimp Litopenaeus vannamei (Boone) fed diets containing phytic acid[J].Aquaculture,2014,422-423:63-68.
[60] RANDHAWA S S, DUA K, SING R S, et al.Effect of supplementation of zinc methionine on claw characteristics in crossbred dairy cattle[J].Ind J Anim Sci,2012,82(3):304-308.
[61] LI Y S, ZHU N H, NIU P P, et al.Effects of dietary chromium methionine on growth performance, carcass composition, meat colour and expression of the colour-related gene myoglobin of growing-finishing pigs[J].Asian-Australasian Journal of Animal Sciences,2013,26(7):1 021-1 029.
[62] KUMAR D, SUBRAMANIAN K, BISARIA V S, et al.Effect of cysteine on methionine production by a regulatory mutant of Corynebacterium lilium[J].Bioresour Technol,2005,96(3):287-294.
[63] 金利群,金伟熔,柳志强.硫模块启动子对提高L-甲硫氨酸的生物合成的影响及发酵培养条件的优化[J].食品与发酵工业,2019,45(19):8-16.
JIN L Q, JIN W R, LIU Z Q.Effect of sulfur module promoter on the improvement of L-methionine biosynthesis and optimization of fermentation conditions[J].Food and Fermentation Industry, 2019, 45(19):8-16.
[64] WANG X X, LIN C P, ZHANG X J, et al.Improvement of a newly cloned carbonyl reductase and its application to biosynthesize chiral intermediate of duloxetine[J].Process Biochem,2018,70:124-128.
