食品与发酵工业 >

2021 , Vol. 47 >Issue 13: 51 - 58

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.025995

研究报告

植物蛋白-益生菌复合制剂对小鼠铅毒性的缓解作用

  • 马申嫣 ,
  • 王晶 ,
  • 朱家民 ,
  • 曹江 ,
  • 翟齐啸 ,
  • 张灏 ,
  • 赵建新 ,
  • 田丰伟 ,
  • 陈卫
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  • (江南大学 食品学院,江苏 无锡,214122)
硕士研究生(田丰伟教授为通讯作者,E-mail: fwtian@jiangnan.edu.cn)

收稿日期: 2020-10-24

  修回日期: 2020-12-12

  网络出版日期: 2021-08-02

收起

Alleviating effects of plant protein-probiotics preparation on lead toxicity in mice

  • MA Shenyan ,
  • WANG Jing ,
  • ZHU Jiaming ,
  • CAO Jiang ,
  • ZHAI Qixiao ,
  • ZHANG Hao ,
  • ZHAO Jianxin ,
  • TIAN Fengwei ,
  • CHEN Wei
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  • (School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

Received date: 2020-10-24

  Revised date: 2020-12-12

  Online published: 2021-08-02

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摘要

铅在体内过量蓄积会引发严重的氧化应激以及神经毒害反应,目前常用的螯合剂对轻度铅中毒的缓解作用较小且有一定的副作用,不能长期使用。植物乳杆菌CCFM8661在前期研究中表现出了良好的铅毒性缓解能力,具有一定的应用前景。该研究通过对植物乳杆菌CCFM8661与植物蛋白进行复配,探究不同复配方式对小鼠铅毒性缓解能力的影响。结果表明,CCFM8661与植物蛋白复配能够显著增强铅毒性缓解能力。其中CCFM8661+大豆蛋白促进小鼠粪便铅排泄,降低组织铅含量及缓解肠道炎症的效果更显著,而CCFM8661+大米蛋白能显著缓解铅对神经系统的毒害及肝肾脏的氧化损伤。同时CCFM8661与2种植物蛋白复配均能更好缓解铅暴露导致的肠道菌群失调。这表明CCFM8661能够与植物蛋白进行复配,并作为一款具有排铅功能的复合膳食补充剂产品进入市场,弥补市场上关于此类产品的空白。

关键词： 铅毒性; 植物乳杆菌; 植物蛋白; 复合配方

本文引用格式

马申嫣 , 王晶 , 朱家民 , 曹江 , 翟齐啸 , 张灏 , 赵建新 , 田丰伟 , 陈卫 . 植物蛋白-益生菌复合制剂对小鼠铅毒性的缓解作用[J]. 食品与发酵工业, 2021 , 47(13) : 51 -58 . DOI: 10.13995/j.cnki.11-1802/ts.025995

Abstract

Lead is a non-essential metal with cumulative toxicity. Excessive accumulation of lead may cause serious oxidative stress and neurotoxic reactions. At present, the commonly chelating agents have a little alleviating effect on mild lead toxicity with side effects. In previous studies, Lactobacillus plantarum CCFM8661 showed good ability to alleviate lead toxicity, which had a promising application prospect. In this study, L. plantarum CCFM8661 was formulated with two plant protein to explore the ability of alleviate lead toxicity. The results showed that plant protein-probiotics formulation could significantly enhance the ability of alleviate lead toxicity and could better alleviate the intestinal flora imbalance which caused by lead exposure. Strain CCFM8661 + soybean protein could accelerate the excretion of fecal lead, reduce the concentration of tissue lead and alleviate intestinal inflammation, while strain CCFM8661 + rice protein could significantly alleviate lead toxicity of nervous system and oxidative damage of liver and kidney. The results indicated that strain CCFM8661 could be used as a dietary supplement with the function of removing lead, which will make up for the blank of this kind of product.

Key words： lead toxicity; Lactobacillus plantarum; plant protein; formulation

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