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食物蛋白源免疫调节肽研究进展

  • 李富强 ,
  • 张廷新 ,
  • 朱丽萍 ,
  • 张楠 ,
  • 颜世敢
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  • (齐鲁工业大学(山东省科学院)生物工程学院,山东省微生物工程重点实验室,山东 济南,250353)
硕士研究生(颜世敢教授为通信作者,E-mail : yanshigan@126.com)

收稿日期: 2021-07-09

  修回日期: 2021-08-12

  网络出版日期: 2022-01-27

基金资助

山东省重点研发计划医用食品专项计划项目(2019YYSP024);山东省自然科学基金项目(ZR2017LD013)

Advance of immunomodulatory peptides from dietary-protein source

  • LI Fuqiang ,
  • ZHANG Tingxin ,
  • ZHU Liping ,
  • ZHANG Nan ,
  • YAN Shigan
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  • (School of Bioengineering,Qilu University of Technology(Shandong Academy of Sciences),Key Laboratory of Microbial Engineering of Shandong Province,Jinan 250353,China)

Received date: 2021-07-09

  Revised date: 2021-08-12

  Online published: 2022-01-27

摘要

免疫系统在维持人类健康方面发挥重要作用,免疫系统功能失调或受损会引发疾病。目前常用的调节免疫功能的化学药物存在价格昂贵、毒副作用大等缺点,因此开发高效、安全的免疫调节制剂成为研究热点。食物蛋白源免疫调节肽是利用食源性蛋白获得的具有调节免疫功能的多肽,其免疫调节活性与氨基酸组成、序列及肽链长度有关。文章综述了近年来食物蛋白源免疫调节活性肽的类型、获取途径、功效评价方法及作用机制,旨在为免疫调节相关的功能性食品或药物的研究及开发提供参考。

本文引用格式

李富强 , 张廷新 , 朱丽萍 , 张楠 , 颜世敢 . 食物蛋白源免疫调节肽研究进展[J]. 食品与发酵工业, 2022 , 48(1) : 308 -314 . DOI: 10.13995/j.cnki.11-1802/ts.028607

Abstract

The immune system plays an important role in maintaining human health.The dysfunction or damage of the immune system can lead to diseases.At present,commonly used medicine for regulating immune function has some disadvantages,such as high cost and serious side effects.As a result,it is essential to develop efficient and safe immunomodulatory medicine.Immunomodulatory peptides are bioactive peptides with immune-regulating activities derived from dietary proteins,and its immunomodulatory activity is relative to the amino acid composition,sequence,and peptide chain length.This paper reviews the types,acquisition methods,efficacy evaluation methods,and mechanisms of food-derived immunomodulatory peptides,which aims at providing reference for the research on functional food or medicine related to immune regulation.

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