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模拟移动床色谱在多组分糖液分离中的研究应用进展

  • 李云飞 ,
  • 栾庆民 ,
  • 刘峰 ,
  • 孙桂莲 ,
  • 张莉 ,
  • 李珍珍 ,
  • 李克文
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  • 1(保龄宝生物股份有限公司,山东 禹城,251200)
    2(山东省功能糖提取与应用技术重点实验室,山东 禹城,251200)
    3(上海交通大学 农业与生物学院,上海,200240)
第一作者:博士,教授(李克文教授级高级工程师为通信作者,E-mail:likwen@126.com)

收稿日期: 2021-07-21

  修回日期: 2021-09-06

  网络出版日期: 2022-06-23

基金资助

2019年泰山产业领军人才项目(传统产业创新类);2020年度山东省重点研发计划(2020CXGC010601)

Development and research of simulated moving bed chromatography in separation of multi-fraction saccharides

  • LI Yunfei ,
  • LUAN Qingmin ,
  • LIU Feng ,
  • SUN Guilian ,
  • ZHANG Li ,
  • LI Zhenzhen ,
  • LI Kewen
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  • 1(Baolingbao Biotechnology Co.Ltd., Yucheng 251200, China)
    2(Shandong Provincial Key Laboratory of Extraction and Application Technology for Functional Glycomics, Yucheng 251200, China)
    3(School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China)

Received date: 2021-07-21

  Revised date: 2021-09-06

  Online published: 2022-06-23

摘要

近些年,关于模拟移动床(simulated moving bed, SMB)色谱在多组分糖液分离方面的应用有大量的相关报道,但是在系统配置与运行模式方面却鲜有归纳总结。该文基于国内外期刊论文和专利文献,分析了SMB色谱的结构变化特点和运行策略。与常规SMB色谱比较,近几年SMB色谱柱配置数量趋于少量化、各区数量多样化。进出口切换时间和顺序逐步细化,通过模拟预测各组分的前锋位移信息,实现多组分的精准分离。发挥批处理色谱和SMB色谱各自优势,两种色谱结合运行模式越来越多。

本文引用格式

李云飞 , 栾庆民 , 刘峰 , 孙桂莲 , 张莉 , 李珍珍 , 李克文 . 模拟移动床色谱在多组分糖液分离中的研究应用进展[J]. 食品与发酵工业, 2022 , 48(11) : 338 -344 . DOI: 10.13995/j.cnki.11-1802/ts.028731

Abstract

A large number of papers and patents on simulated moving bed (SMB) chromatography used in the separation of multi-fraction saccharides have been published recently. However, the comprehensive review on the column configuration and operation strategies of SMB was limited. Compared with classic SMB, the following characteristics and operating strategies were summarized: the number of columns tends to be fewer and variable; switch time of ports is divided more substeps; the profile front of concentration is predicted and separated more accurately; the combination of batchwise chromatography and SMB has been employed widely to make full use of each advantage.

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