综述与专题评论

异荭草素调控糖尿病的作用机制研究进展

  • 闫科润 ,
  • 沈玥 ,
  • 李宁 ,
  • 黄现青 ,
  • 乔明武 ,
  • 宋莲军
展开
  • (河南农业大学 食品科学技术学院, 河南省食品加工与流通安全控制工程技术研究中心, 河南 郑州,450000)
第一作者:硕士研究生(宋莲军教授为通信作者,E-mail:slj69@126.com)

收稿日期: 2021-12-08

  修回日期: 2022-01-26

  网络出版日期: 2022-12-20

基金资助

河南省优青项目(202300410193);2022年河南省研究生联合培养基地项目(YJS2022JD16)

Research progress on the mechanism of isoorientin in regulating diabetes mellitus

  • YAN Kerun ,
  • SHEN Yue ,
  • LI Ning ,
  • HUANG Xianqing ,
  • QIAO Mingwu ,
  • SONG Lianjun
Expand
  • (College of Food Science and Technology, Henan Agricultural Univercity, Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control, Zhengzhou 450000, China)

Received date: 2021-12-08

  Revised date: 2022-01-26

  Online published: 2022-12-20

摘要

异荭草素是一种天然的黄酮类物质,实验证明其具有改善糖尿病的功能,且对一型和二型糖尿病都有作用。为了更好地了解异荭草素的作用机制,该文就异荭草素在促进葡萄糖的吸收、缓解胰岛素抵抗及氧化应激、促进线粒体生物发生等方面的作用机制进行阐述,并对异荭草素调控糖尿病及其并发症的研究前景作出展望,以期促进异荭草素的开发和利用,为异荭草素在食品行业及临床治疗中的应用提供理论依据。

本文引用格式

闫科润 , 沈玥 , 李宁 , 黄现青 , 乔明武 , 宋莲军 . 异荭草素调控糖尿病的作用机制研究进展[J]. 食品与发酵工业, 2022 , 48(22) : 338 -344 . DOI: 10.13995/j.cnki.11-1802/ts.030374

Abstract

Isoorientin is a kind of natural flavonoid, which has been proved to have the function of improving diabetes, and has effects on both type 1 and type 2 diabetes mellitus. In order to better understand the mechanism of isoorientin, this paper expounds on the mechanism of isoorientin in promoting the absorption of glucose, alleviating insulin resistance and oxidative stress, and promoting mitochondrial biogenesis, the research prospect of isoorientin regulating diabetes and its complications prospected, in order to promote the development and utilization of isoorientin. To provide a theoretical basis for the application of isoorientin in the food industry and clinical treatment.

参考文献

[1] SAEEDI P, PETERSOHN I, SALPEA P, et al.Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045:Results from the international diabetes federation diabetes atlas, 9th edition[J].Diabetes Research and Clinical Practice, 2019, 157:107843.
[2] NARAIN N.Potential of passion (Passiflora spp.) fruit in control of type Ⅱ diabetes[J].Current Research in Diabetes & Obesity Journal, 2018, 7(3):555712.
[3] DÍAZ-AMADOR R, CAÑIZARES-CARMENATE Y, TABOADA-CRISPI A, et al.Computational modeling of aldose reductase inhibitory activity of flavonoids derivatives for diabetic complications treatment[J].Letters in Drug Design and Discovery, 2021, 18(11):1 094-1 105.
[4] 杜伟奇, 施秀芳, 邱明艳, 等.治疗糖尿病药物的研究进展[J].中国医院药学杂志, 2005, 25(1):67-69.
DU W Q, SHI X F, QIU M Y, et al.Research progress of drugs for treating diabetes mellitus[J].Chinese Journal of Hospital Pharmacy, 2005, 25(1):67-69.
[5] EDDOUKS M, BIDI A, EL BOUHALI B, et al.Antidiabetic plants improving insulin sensitivity[J].Journal of Pharmacy and Pharmacology, 2014, 66(9):1 197-1 214.
[6] 魏丽娟, 易倩, 张曲, 等.一测多评法测定藜麦中6种酚类成分[J].食品工业科技, 2018, 39(19):232-236;242.
WEI L J, YI Q, ZHANG Q, et al.Determination of six polyphenols in Chenopodium quinoa eilld(quinoa)by quantitative analysis of multi-components by single marker method[J].Science and Tech- nology of Food Industry, 2018, 39(19):232-236;242.
[7] LUYEN B T T, THAO N P, TAI B H, et al.Chemical constituents of Triticum aestivum and their effects on adipogenic differentiation of 3T3-L1 preadipocytes[J].Archives of Pharmacal Research, 2015, 38(6):1 011-1 018.
[8] NAM T G, LIM T G, LEE B H, et al.Comparison of anti-inflammatory effects of flavonoid-rich common and tartary buckwheat sprout extracts in lipopolysaccharide-stimulated RAW 264.7 and peritoneal macrophages[J].Oxidative Medicine & Cellular Longevity, 2017, 2017:9658030.
[9] KUMARAN A, HO C C, HWANG L S.Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease[J].Journal of Food and Drug Analysis, 2018, 26(1):172-181.
[10] SALLES B C C, DA SILVA M A, TANIGUTHI L, et al.Passiflora edulis leaf extract:Evidence of antidiabetic and antiplatelet effects in rats[J]. Biological and Pharmaceutical Bulletin, 2020, 43(1):169-174.
[11] LEE C W, SEO J Y, KIM S L, et al.Corn silk maysin ameliorates obesity in vitro and in vivo via suppression of lipogenesis, differentiation, and function of adipocytes[J].Biomedicine & Pharmacotherapy, 2017, 93:267-275.
[12] MOHANBABU A V R, KISHORE M K K, CHANDRASHEKAR B R, et al. Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats [J]. Journal of Basic and Clinical Physiology and Pharmacology, 2015, 26(2):201-209.
[13] LUAN G X, WANG Y W, WANG Z H, et al. Flavonoid glycosides from fenugreek seeds regulate glycolipid metabolism by improving mitochondrial function in 3T3-L1 adipocytes in vitro[J]. Journal of Agricultural & Food Chemistry, 2018, 66(12):3 169-3 178.
[14] ANILKUMAR K, REDDY G V, AZAD R, et al.Evaluation of anti-inflammatory properties of isoorientin isolated from tubers of Pueraria tuberosa[J].Oxidative Medicine and Cellular Longevity, 2017.DOI:10.1155/2017/5498054.
[15] LÓPEZ-LÁZARO M. Distribution and biological activities of the flavonoid luteolin [J]. Mini Reviews in Medicinal Chemistry, 2009, 9(1):31-59.
[16] XIAO J B, CAPANOGLU E, JASSBI A R, et al.Advance on the flavonoid C-glycosides and health benefits [J]. Critical Reviews in Food Science & Nutrition, 2016, 56(Suppl1):S29-S45.
[17] CHOI J S, ISLAM M N, ALI M Y, et al.The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities [J]. Archives of Pharmacal Research, 2014, 37(10):1 354-1 363.
[18] 袁莉, 吴雨晨, 任骁萌, 等. 荭草素和异荭草素抗氧化活性及对肝癌细胞增殖的影响[ J]. 食品科学技术学报, 2013, 31(6):21-27.
YUAN L, WU Y C, REN X M, et al.Comparison of antioxidant ac-tivities and cytotoxicity in HepG 2 cells of orientin and isoorientin[J]. Journal of Food Science and Technology, 2013, 31 ( 6 ):21-27.
[19] 张琴. 异荭草素对人宫颈癌hela 细胞凋亡的影响[D]. 衡阳:南华大学, 2018.
ZHANG Q. Effects of isoorientin on hela cells apoptosis in cervical cancer[D]. Hengyang:University of South China, 2018.
[20] TEIXEIRA F M, COELHO M N, JOSÉ-CHAGAS F D N, et al.Oral treatments with a flavonoid-enriched fraction from Cecropia hololeuca and with rutin reduce articular pain and inflammation in murine zymosan-induced arthritis [J]. Journal of Ethnopharmacology, 2020, 260:112841.
[21] 朱秀珍, 申文伟, 龚翠莹, 等. 异荭草苷体内外抗呼吸道合胞病毒活性研究[J]. 中山大学学报( 医学科学版), 2015, 36(3):352-359.
ZHU X Z, SHEN W W, GONG C Y, et al. Antiviral activity of isoorientin against respiratory syncytial virus in vitro and in vivo [J]. Journal of Sun Yat-Sen University (Medical Sciences), 2015, 36(3):352-359.
[22] IBRAHIM R M, EL-HALAWANY A M, SALEH D O, et al.HPLC-DAD-MS/ MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic ac-tivities[J]. Revista Brasileira de Farmacognosia, 2015, 25(2):134-141.
[23] GASPAR M C, FONSECA D A, ANTUNES M J, et al.Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract [J].Natural Product Research, 2018, 32(6):732-738.
[24] XU G K, QIN X Y, WANG G K, et al. Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet- and streptozotocin-induced Type 2 diabetic rats [J]. Chinese Journal of Natural Medicines, 2017, 15(3):168-177.
[25] ANDRADE-CETTO A, WIEDENFELD H. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats [J]. Journal of Ethnopharmacology, 2001, 78(2-3):145-149.
[26] SEZIK E, ASLAN M, YESILADA E, et al.Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques [J]. Life Sciences, 2005, 76(11):1 223-1 238.
[27] ALONSO-CASTRO A J, ZAPATA-BUSTOS R, GÓMEZ-ESPINOZA G, et al.Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway [J].Endocrinology, 2012, 153(11):5 222-5 230.
[28] WAN H, WANG B, CUI Y K, et al. Low-level lead exposure promotes hepatic gluconeogenesis and contributes to the elevation of fasting glucose level [J].Chemosphere, 2021, 276(71):130111.
[29] ANDRADE-CETTO A, VÁZQUEZ R C. Gluconeogenesis inhibition and phytochemical composition of two Cecropia species[J].Journal of Ethnopharmacology, 2010, 130(1):93-97.
[30] KASANGANA P B, EID H M, NACHAR A, et al. Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv. :The ethyl acetate fraction contains bioactive phenolic compounds that improve liver cell glucose homeostasis[J].Journal of Ethnopharmacology, 2019, 245:112167.
[31] ROSEN E D, SARRAF P, TROY A E, et al.PPAR γ is required for the differentiation of adipose tissue in vivo and in vitro[J]. Molecular Cell, 1999, 4(4):611-617.
[32] POUDEL B, NEPALI S, XIN M J, et al. Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway [J]. Molecular Medicine Reports, 2015, 12 (2): 3 139-3 145.
[33] MAZIBUKO-MBEJE S E, ZIQUBU K, DLUDLA P V, et al. Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes [J]. Metabolism Open, 2020, 6:100037.
[34] MALIK A, JAMIL U, BUTT T T, et al. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model [J]. Drug Design, Development and Therapy, 2019, 13:1 501-1 513.
[35] GOLDENTHAL M J, MARÍN-GARCÍA J.Mitochondrial signaling pathways:A receiver/ integrator organelle [J]. Molecular and Cellular Biochemistry, 2004, 262(1-2):1-16.
[36] KAAMAN M, SPARKS L M, VAN HARMELEN V, et al. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue [J]. Diabetologia, 2007, 50(12):2 526-2 533.
[37] ZIQUBU K, MULLER C J F, DLUDLA P V, et al. Impact of isoorientin on metabolic activity and lipid accumulation in differentiated adipocytes [J]. Molecules (Basel, Switzerland), 2020, 25(8):1773.
[38] ABUELIZZ H A, ANOUAR E H, AHMAD R, et al. Triazoloquinazolines as a new class of potent α-glucosidase inhibitors:In vitro evaluation and docking study[J].PLoS One, 2019, 14(8):e0220379.
[39] ZHANG X L, LI G L, WU D, et al.Emerging strategies for the activity assay and inhibitor screening of alpha-glucosidase [J]. Food Function, 2020, 11(1):66-82.
[40] DE LAAR F A V. Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes [J]. Vascular Health and Risk Management, 2008, 4(6):1 189-1 195.
[41] SHIBANO M, KAKUTANI K, TANIGUCHI M, et al.Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity [J]. Journal of Natural Medicines, 2008, 62(3):349-353.
[42] BORGES P H O, PEDREIRO S, BAPTISTA S J, et al. Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) stapf[J].Journal of Ethnopharmacology, 2021, 280:114470.
[43] MULLER C J F, MALHERBE C J, CHELLAN N, et al. Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(beta-D-glucopyranosyloxy)- 3-phenylpropenoic acid in prevention of metabolic syndrome [J]. Critical Reviews in Food Science and Nutrition, 2018, 58(2):227-246.
[44] ANNAPURNA H V, APOORVA B, RAVICHANDRAN N, et al. Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.)[J].Journal of Molecular Graphics and Modelling, 2013, 39:87-97.
[45] WOODWARD C, MAGWENZI S G, WRAITH K S, et al. Oxidised LDL activates blood platelets through CD36-NADPH oxidasemediated inhibition of the cgmp/protein kinase g signalling cascade[J].Atherosclerosis, 2015, 241(1):e5-e6.
[46] SALLES B C C, LEME K C, DA SILVA M A, et al.Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats[J].Journal of Pharmacy and Pharmacology, 2021, 73(10):1 361-1 368.
[47] KANDANDAPANI S, BALARAMAN A K, AHAMED H N.Extracts of passion fruit peel and seed of Passiflora edulis (Passifloraceae) attenuate oxidative stress in diabetic rats [J]. Chinese Journal of Natural Medicines, 2015, 13(9):680-686.
[48] YUAN L, HAN X, LI W F, et al. Isoorientin prevents hyperlipidaemia and liver injury by regulating lipid metabolism, antioxidant capability and inflammatory cytokine release in high-fructose-fed mice [J]. Journal of Agricultural & Food Chemistry, 2016, 64(13):2 682-2 689.
[49] 周岚. 姜德友教授治疗2型糖尿病的用药规律研究[D].哈尔滨:黑龙江中医药大学, 2021.
ZHOU L.Study on the medication regularity of professor Jiang Deyou in the treatment of type 2 diabetes mellitus [D]. Harbin:Heilongjiang University of Chinese Medicine, 2021.
[50] 李芸芳. 中药抗糖尿病活性筛选及作用机制研究[D]. 武汉: 武汉大学, 2017.
LI Y F.Anti-diabetic activity screening of traditional Chinese medicines and the molecular mechanism[D].Wuhan:Wuhan University, 2017.
文章导航

/