[1] SAEEDI P, PETERSOHN I, SALPEA P, et al.Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045:Results from the international diabetes federation diabetes atlas, 9th edition[J].Diabetes Research and Clinical Practice, 2019, 157:107843.
[2] NARAIN N.Potential of passion (Passiflora spp.) fruit in control of type Ⅱ diabetes[J].Current Research in Diabetes & Obesity Journal, 2018, 7(3):555712.
[3] DÍAZ-AMADOR R, CAÑIZARES-CARMENATE Y, TABOADA-CRISPI A, et al.Computational modeling of aldose reductase inhibitory activity of flavonoids derivatives for diabetic complications treatment[J].Letters in Drug Design and Discovery, 2021, 18(11):1 094-1 105.
[4] 杜伟奇, 施秀芳, 邱明艳, 等.治疗糖尿病药物的研究进展[J].中国医院药学杂志, 2005, 25(1):67-69.
DU W Q, SHI X F, QIU M Y, et al.Research progress of drugs for treating diabetes mellitus[J].Chinese Journal of Hospital Pharmacy, 2005, 25(1):67-69.
[5] EDDOUKS M, BIDI A, EL BOUHALI B, et al.Antidiabetic plants improving insulin sensitivity[J].Journal of Pharmacy and Pharmacology, 2014, 66(9):1 197-1 214.
[6] 魏丽娟, 易倩, 张曲, 等.一测多评法测定藜麦中6种酚类成分[J].食品工业科技, 2018, 39(19):232-236;242.
WEI L J, YI Q, ZHANG Q, et al.Determination of six polyphenols in Chenopodium quinoa eilld(quinoa)by quantitative analysis of multi-components by single marker method[J].Science and Tech- nology of Food Industry, 2018, 39(19):232-236;242.
[7] LUYEN B T T, THAO N P, TAI B H, et al.Chemical constituents of Triticum aestivum and their effects on adipogenic differentiation of 3T3-L1 preadipocytes[J].Archives of Pharmacal Research, 2015, 38(6):1 011-1 018.
[8] NAM T G, LIM T G, LEE B H, et al.Comparison of anti-inflammatory effects of flavonoid-rich common and tartary buckwheat sprout extracts in lipopolysaccharide-stimulated RAW 264.7 and peritoneal macrophages[J].Oxidative Medicine & Cellular Longevity, 2017, 2017:9658030.
[9] KUMARAN A, HO C C, HWANG L S.Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease[J].Journal of Food and Drug Analysis, 2018, 26(1):172-181.
[10] SALLES B C C, DA SILVA M A, TANIGUTHI L, et al.Passiflora edulis leaf extract:Evidence of antidiabetic and antiplatelet effects in rats[J]. Biological and Pharmaceutical Bulletin, 2020, 43(1):169-174.
[11] LEE C W, SEO J Y, KIM S L, et al.Corn silk maysin ameliorates obesity in vitro and in vivo via suppression of lipogenesis, differentiation, and function of adipocytes[J].Biomedicine & Pharmacotherapy, 2017, 93:267-275.
[12] MOHANBABU A V R, KISHORE M K K, CHANDRASHEKAR B R, et al. Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats [J]. Journal of Basic and Clinical Physiology and Pharmacology, 2015, 26(2):201-209.
[13] LUAN G X, WANG Y W, WANG Z H, et al. Flavonoid glycosides from fenugreek seeds regulate glycolipid metabolism by improving mitochondrial function in 3T3-L1 adipocytes in vitro[J]. Journal of Agricultural & Food Chemistry, 2018, 66(12):3 169-3 178.
[14] ANILKUMAR K, REDDY G V, AZAD R, et al.Evaluation of anti-inflammatory properties of isoorientin isolated from tubers of Pueraria tuberosa[J].Oxidative Medicine and Cellular Longevity, 2017.DOI:10.1155/2017/5498054.
[15] LÓPEZ-LÁZARO M. Distribution and biological activities of the flavonoid luteolin [J]. Mini Reviews in Medicinal Chemistry, 2009, 9(1):31-59.
[16] XIAO J B, CAPANOGLU E, JASSBI A R, et al.Advance on the flavonoid C-glycosides and health benefits [J]. Critical Reviews in Food Science & Nutrition, 2016, 56(Suppl1):S29-S45.
[17] CHOI J S, ISLAM M N, ALI M Y, et al.The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities [J]. Archives of Pharmacal Research, 2014, 37(10):1 354-1 363.
[18] 袁莉, 吴雨晨, 任骁萌, 等. 荭草素和异荭草素抗氧化活性及对肝癌细胞增殖的影响[ J]. 食品科学技术学报, 2013, 31(6):21-27.
YUAN L, WU Y C, REN X M, et al.Comparison of antioxidant ac-tivities and cytotoxicity in HepG 2 cells of orientin and isoorientin[J]. Journal of Food Science and Technology, 2013, 31 ( 6 ):21-27.
[19] 张琴. 异荭草素对人宫颈癌hela 细胞凋亡的影响[D]. 衡阳:南华大学, 2018.
ZHANG Q. Effects of isoorientin on hela cells apoptosis in cervical cancer[D]. Hengyang:University of South China, 2018.
[20] TEIXEIRA F M, COELHO M N, JOSÉ-CHAGAS F D N, et al.Oral treatments with a flavonoid-enriched fraction from Cecropia hololeuca and with rutin reduce articular pain and inflammation in murine zymosan-induced arthritis [J]. Journal of Ethnopharmacology, 2020, 260:112841.
[21] 朱秀珍, 申文伟, 龚翠莹, 等. 异荭草苷体内外抗呼吸道合胞病毒活性研究[J]. 中山大学学报( 医学科学版), 2015, 36(3):352-359.
ZHU X Z, SHEN W W, GONG C Y, et al. Antiviral activity of isoorientin against respiratory syncytial virus in vitro and in vivo [J]. Journal of Sun Yat-Sen University (Medical Sciences), 2015, 36(3):352-359.
[22] IBRAHIM R M, EL-HALAWANY A M, SALEH D O, et al.HPLC-DAD-MS/ MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic ac-tivities[J]. Revista Brasileira de Farmacognosia, 2015, 25(2):134-141.
[23] GASPAR M C, FONSECA D A, ANTUNES M J, et al.Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract [J].Natural Product Research, 2018, 32(6):732-738.
[24] XU G K, QIN X Y, WANG G K, et al. Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet- and streptozotocin-induced Type 2 diabetic rats [J]. Chinese Journal of Natural Medicines, 2017, 15(3):168-177.
[25] ANDRADE-CETTO A, WIEDENFELD H. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats [J]. Journal of Ethnopharmacology, 2001, 78(2-3):145-149.
[26] SEZIK E, ASLAN M, YESILADA E, et al.Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques [J]. Life Sciences, 2005, 76(11):1 223-1 238.
[27] ALONSO-CASTRO A J, ZAPATA-BUSTOS R, GÓMEZ-ESPINOZA G, et al.Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway [J].Endocrinology, 2012, 153(11):5 222-5 230.
[28] WAN H, WANG B, CUI Y K, et al. Low-level lead exposure promotes hepatic gluconeogenesis and contributes to the elevation of fasting glucose level [J].Chemosphere, 2021, 276(71):130111.
[29] ANDRADE-CETTO A, VÁZQUEZ R C. Gluconeogenesis inhibition and phytochemical composition of two Cecropia species[J].Journal of Ethnopharmacology, 2010, 130(1):93-97.
[30] KASANGANA P B, EID H M, NACHAR A, et al. Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv. :The ethyl acetate fraction contains bioactive phenolic compounds that improve liver cell glucose homeostasis[J].Journal of Ethnopharmacology, 2019, 245:112167.
[31] ROSEN E D, SARRAF P, TROY A E, et al.PPAR γ is required for the differentiation of adipose tissue in vivo and in vitro[J]. Molecular Cell, 1999, 4(4):611-617.
[32] POUDEL B, NEPALI S, XIN M J, et al. Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway [J]. Molecular Medicine Reports, 2015, 12 (2): 3 139-3 145.
[33] MAZIBUKO-MBEJE S E, ZIQUBU K, DLUDLA P V, et al. Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes [J]. Metabolism Open, 2020, 6:100037.
[34] MALIK A, JAMIL U, BUTT T T, et al. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model [J]. Drug Design, Development and Therapy, 2019, 13:1 501-1 513.
[35] GOLDENTHAL M J, MARÍN-GARCÍA J.Mitochondrial signaling pathways:A receiver/ integrator organelle [J]. Molecular and Cellular Biochemistry, 2004, 262(1-2):1-16.
[36] KAAMAN M, SPARKS L M, VAN HARMELEN V, et al. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue [J]. Diabetologia, 2007, 50(12):2 526-2 533.
[37] ZIQUBU K, MULLER C J F, DLUDLA P V, et al. Impact of isoorientin on metabolic activity and lipid accumulation in differentiated adipocytes [J]. Molecules (Basel, Switzerland), 2020, 25(8):1773.
[38] ABUELIZZ H A, ANOUAR E H, AHMAD R, et al. Triazoloquinazolines as a new class of potent α-glucosidase inhibitors:In vitro evaluation and docking study[J].PLoS One, 2019, 14(8):e0220379.
[39] ZHANG X L, LI G L, WU D, et al.Emerging strategies for the activity assay and inhibitor screening of alpha-glucosidase [J]. Food Function, 2020, 11(1):66-82.
[40] DE LAAR F A V. Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes [J]. Vascular Health and Risk Management, 2008, 4(6):1 189-1 195.
[41] SHIBANO M, KAKUTANI K, TANIGUCHI M, et al.Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity [J]. Journal of Natural Medicines, 2008, 62(3):349-353.
[42] BORGES P H O, PEDREIRO S, BAPTISTA S J, et al. Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) stapf[J].Journal of Ethnopharmacology, 2021, 280:114470.
[43] MULLER C J F, MALHERBE C J, CHELLAN N, et al. Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(beta-D-glucopyranosyloxy)- 3-phenylpropenoic acid in prevention of metabolic syndrome [J]. Critical Reviews in Food Science and Nutrition, 2018, 58(2):227-246.
[44] ANNAPURNA H V, APOORVA B, RAVICHANDRAN N, et al. Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.)[J].Journal of Molecular Graphics and Modelling, 2013, 39:87-97.
[45] WOODWARD C, MAGWENZI S G, WRAITH K S, et al. Oxidised LDL activates blood platelets through CD36-NADPH oxidasemediated inhibition of the cgmp/protein kinase g signalling cascade[J].Atherosclerosis, 2015, 241(1):e5-e6.
[46] SALLES B C C, LEME K C, DA SILVA M A, et al.Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats[J].Journal of Pharmacy and Pharmacology, 2021, 73(10):1 361-1 368.
[47] KANDANDAPANI S, BALARAMAN A K, AHAMED H N.Extracts of passion fruit peel and seed of Passiflora edulis (Passifloraceae) attenuate oxidative stress in diabetic rats [J]. Chinese Journal of Natural Medicines, 2015, 13(9):680-686.
[48] YUAN L, HAN X, LI W F, et al. Isoorientin prevents hyperlipidaemia and liver injury by regulating lipid metabolism, antioxidant capability and inflammatory cytokine release in high-fructose-fed mice [J]. Journal of Agricultural & Food Chemistry, 2016, 64(13):2 682-2 689.
[49] 周岚. 姜德友教授治疗2型糖尿病的用药规律研究[D].哈尔滨:黑龙江中医药大学, 2021.
ZHOU L.Study on the medication regularity of professor Jiang Deyou in the treatment of type 2 diabetes mellitus [D]. Harbin:Heilongjiang University of Chinese Medicine, 2021.
[50] 李芸芳. 中药抗糖尿病活性筛选及作用机制研究[D]. 武汉: 武汉大学, 2017.
LI Y F.Anti-diabetic activity screening of traditional Chinese medicines and the molecular mechanism[D].Wuhan:Wuhan University, 2017.