综述与专题评论

胶原蛋白改善骨关节健康的研究进展

  • 马晨玮 ,
  • 田晓静 ,
  • 张凯 ,
  • 汪洋 ,
  • 张亚飞 ,
  • 刘新柱 ,
  • 王稳航
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  • 1(天津科技大学 食品科学与工程学院,天津,300457)
    2(星甲(天津)生物技术有限公司 卡勒贞产品开发中心,天津,300457)
第一作者:硕士研究生(王稳航研究员为通信作者,E-mail:wangwenhang @tust.edu.cn)

收稿日期: 2022-07-13

  修回日期: 2022-08-03

  网络出版日期: 2023-02-14

基金资助

国家自然基金面上项目(32172249);天津市合成生物技术创新能力提升行动专项(TSBICIP-KJGG-004)

Research progress of collagen in improving the joint health

  • MA Chenwei ,
  • TIAN Xiaojing ,
  • ZHANG Kai ,
  • WANG Yang ,
  • ZHANG Yafei ,
  • LIU Xinzhu ,
  • WANG Wenhang
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  • 1(College of Food Science and Technology, Tianjin University of Science and Technology, Tianjin 300457, China)
    2(R&D Centre of Collagen Products, Xingjia Biotechnology Co.Ltd., Tianjin 300457, China)

Received date: 2022-07-13

  Revised date: 2022-08-03

  Online published: 2023-02-14

摘要

骨关节炎是人群中最常见的一种影响关节健康的疾病,目前针对骨关节炎的治疗方法主要是服用多种药物,但这些药物在治疗的同时会带来一些副作用,例如皮疹、过敏、肾功能损害、心血管疾病等。随着营养学的迅速发展,骨关节炎患者希望通过营养补充剂来改善骨关节的健康问题。胶原蛋白已被提议作为改善关节炎的潜在营养补充剂。因此,该文从关节结构成分的损坏、炎症和衰老方面讨论了骨关节炎的发病机制,同时从体外刺激软骨细胞合成细胞外基质大分子、免疫调节和抑制软骨细胞肥大3个方面对胶原蛋白的作用机制展开讨论,以探究胶原蛋白作为营养补充剂用于改善骨关节炎的潜在机制,为胶原蛋白在骨关节健康方面的应用提供理论参考。

本文引用格式

马晨玮 , 田晓静 , 张凯 , 汪洋 , 张亚飞 , 刘新柱 , 王稳航 . 胶原蛋白改善骨关节健康的研究进展[J]. 食品与发酵工业, 2023 , 49(1) : 305 -312 . DOI: 10.13995/j.cnki.11-1802/ts.032967

Abstract

Osteoarthritis(OA)is the most common disease that affects joint health. At present, the treatment methods for OA are mainly by taking a variety of drugs, but these drugs will bring some side effects in the treatment, such as rash, allergies, kidney damage, and cardiovascular disease. Therefore, many patients hope to manage OA through nutritional supplements. Collagen has been proposed as a potential and attractive nutritional supplement for OA. In this paper, the pathogenesis of OA was discussed from the damage of joint structural components, and inflammation and ageing of joint, and the action mechanism of collagen was also discussed from three aspects, including stimulating chondrocytes to synthesize extracellular matrix macromolecules in vitro, immunomodulating and inhibiting chondrocyte hypertrophy, to explain how collagen can be used as a potential food supplement to improve OA and provide a theoretical basis for the application of collagen in joint health.

参考文献

[1] SCHRIEBER R, GAREIS H.Gelatine handbook:Theory and industrial practice[M].Hoboken:Wiley, 2007.
[2] RAGLE R L, SAWITZKE A D.Nutraceuticals in the management of osteoarthritis:A critical review[J].Drugs & Aging, 2012, 29(9):717-731.
[3] 景淑萍. 胶原蛋白的安全性及其保健功能[J].甘肃高师学报, 2009, 14(5):82-83;89.
JING S P.On the safety of collagen and its application functions in healthcare industry[J].Journal of Gansu Normal Colleges, 2009, 14(5):82-83;89.
[4] 钱善华. 天然关节软骨的摩擦行为研究[D].徐州:中国矿业大学, 2009.
QIAN S H.Study on friction behavior about natural articular cartialge[D].Xuzhou:China University of Mining and Technology, 2009.
[5] JAABAR I, MICHE A, WANHERDRICK K, et al.Composition and structure of human cartilage extracellular matrix:Unravelling changes during osteoarthrosis at the nanoscale[J].Osteoarthritis and Cartilage, 2021, 29:S198.
[6] AIGNER T, SÖDER S, GEBHARD P M, et al.Mechanisms of Disease:Role of chondrocytes in the pathogenesis of osteoarthritis:Structure, chaos and senescence[J].Nature Clinical Practice Rheumatology, 2007, 3(7):391-399.
[7] MURPHY C A, GARG A K, SILVA-CORREIA J, et al.The Meniscus in normal and osteoarthritic tissues:Facing the structure property challenges and current treatment trends[J].Annual Review of Biomedical Engineering, 2019, 21:495-521.
[8] KIM H A, LEE Y J, SEONG S C, et al.Apoptotic chondrocyte death in human osteoarthritis[J].The Journal of Rheumatology, 2000, 27(2):455-462.
[9] 王斌, 邢丹, 董圣杰, 等.中国膝骨关节炎流行病学和疾病负担的系统评价[J].中国循证医学杂志, 2018, 18(2):134-142.
WANG B, XING D, DONG S J, et al.Prevalence and disease burden of knee osteoarthritis in China:A systematic review[J].Chinese Journal of Evidence-Based Medicine, 2018, 18(2):134-142.
[10] MAIESE K.Picking a bone with WISP1 (CCN4):New strategies against degenerative joint disease[J].Journal of Translational Science, 2016, 1(3):83-85.
[11] LEONG D J, CHOUDHURY M, HIRSH D M, et al.Nutraceuticals:potential for chondroprotection and molecular targeting of osteoarthritis[J].International Journal of Molecular Sciences, 2013, 14(11):23 063-23 085.
[12] NEOGI T.The epidemiology and impact of pain in osteoarthritis[J].Osteoarthritis and Cartilage, 2013, 21(9):1 145-1 153.
[13] LITWIC A, EDWARDS M H, DENNISON E M, et al.Epidemiology and burden of osteoarthritis[J].British Medical Bulletin, 2013, 105:185-199.
[14] BERTHELOT G, JOHNSON S, NOIREZ P, et al.The age-performance relationship in the general population and strategies to delay age related decline in performance[J].Archives of Public Health, 2019, 77:51.
[15] SALMON J H, RAT A C, SELLAM J, et al.Economic impact of lower-limb osteoarthritis worldwide:A systematic review of cost-of-illness studies[J].Osteoarthritis and Cartilage, 2016, 24(9):1 500-1 508.
[16] MOBASHERI A.The future of osteoarthritis therapeutics:Emerging biological therapy[J].Current Rheumatology Reports, 2013, 15(12):1-9.
[17] 高宗强, 郭雄, 陈君长, 等.大骨节病、骨关节炎软骨细胞分泌IL-1β、TNF-α及透明质酸对其影响实验研究[J].陕西医学杂志, 2015, 44(7):774-778.
GAO Z Q, GUO X, CHEN J C, et al.The effect of hyluronic acid on the expression of IL-1β, TNF-α in chondrocytes of Kashin-beck disease and osteoarthritis cultured in vitro[J].Shaanxi Medical Journal, 2015, 44(7):774-778.
[18] MALEMUD C J.Anticytokine therapy for osteoarthritis:Evidence to date[J].Drugs & Aging, 2010, 27(2):95-115.
[19] GOLDRING M B.Anticytokine therapy for osteoarthritis[J].Expert Opinion on Biological Therapy, 2001, 1(5):817-829.
[20] ZHOU X R, YANG H J, GUAN F, et al.T-2 toxin alters the levels of collagen II and its regulatory enzymes MMPs/TIMP-1 in a low-selenium rat model of kashin-beck disease[J].Biological Trace Element Research, 2016, 169(2):237-246.
[21] TONG T, ZHAO W, WU Y Q, et al.Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis[J].Inflammation Research, 2010, 59(5):369-377.
[22] PRIETO-ALHAMBRA D, JUDGE A, JAVAID M K, et al.Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis:Influences of age, gender and osteoarthritis affecting other joints[J].Annals of the Rheumatic Diseases, 2014, 73(9):1 659-1 664.
[23] GAO S G, ZENG C, LI L J, et al.Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis[J].International Journal of Rheumatic Diseases, 2016, 19(3):226-232.
[24] JEON O H, KIM C, LABERGE R M,et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment[J]. Nature Medicine, 2017,23(6): 775-781.
[25] CHILDS B G, GLUSCEVIC M, BAKER D J, et al.Senescent cells:An emerging target for diseases of ageing[J].Nature Reviews Drug Discovery, 2017, 16(10):718-735.
[26] XU M, BRADLEY E W, WEIVODA M M, et al.Transplanted senescent cells induce an osteoarthritis-like condition in mice[J].The Journals of Gerontology:Series A, 2016, 72(6):780-785.
[27] SHEN X H, CUI Y.Progress in traditional Chinese and Western medicine treatments and nursing care of knee osteoarthritis[J].Chinese Nursing Research, 2015, 2(2-3):71-74.
[28] DEHGHAN M, SAFFARI M, RAFIEIAN-KOPAEI M, et al.Comparison of the effect of topical Hedera helix L.extract gel to diclofenac gel in the treatment of knee osteoarthritis[J].Journal of Herbal Medicine, 2020, 22:100350.
[29] UNGPRASERT P, CHEUNGPASITPORN W, CROWSON C S, et al.Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury:A systematic review and meta-analysis of observational studies[J].European Journal of Internal Medicine, 2015, 26(4):285-291.
[30] CATELLA-LAWSON F, REILLY M P, KAPOOR S C, et al.Cyclooxygenase inhibitors and the antiplatelet effects of aspirin[J].The New England Journal of Medicine, 2001, 345(25):1 809-1 817.
[31] UEBELHART D.Clinical review of chondroitin sulfate in osteoarthritis[J].Osteoarthritis and Cartilage, 2008, 16:S19-S21.
[32] LIU Q, WANG J F, SUN Y J, et al.Chondroitin sulfate from sturgeon bone protects chondrocytes via inhibiting apoptosis in osteoarthritis[J].International Journal of Biological Macromolecules, 2019, 134:1 113-1 119.
[33] DEAL C L, MOSKOWITZ R W.Nutraceuticals as therapeutic agents in osteoarthritis.The role of glucosamine, chondroitin sulfate, and collagen hydrolysate[J].Rheum Dis Clin North Am, 1999, 25(2):379-395.
[34] HOUPT J B, MCMILLAN R, WEIN C, et al.Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee[J].The Journal of Rheumatology, 1999, 26(11):2 423-2 430.
[35] WANDEL S, JÜNI P, TENDAL B, et al.Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee:Network meta-analysis[J].BMJ (Clinical Research Ed.), 2010, 341:c4675.
[36] GARZON C, MIHAILOVIC A, JIAN-YU E, et al.Evaluation of away-from-home excursion patterns after falling among individuals with glaucoma:A longitudinal study[J].BMC Geriatrics, 2022, 22(1):101.
[37] ADAM M.Therapie der osteoarthrose-welche wirkung haben gelantinepraparate? [J].Therapiewoche, 1991, 41.
[38] NAGLER-ANDERSON C, BOBER L A, ROBINSON M E, et al.Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen[J].Evidence-Based Complementary and Alternative Medicine, 1986, 83(19):7 443-7 446.
[39] DI CESARE MANNELLI L, MICHELI L, ZANARDELLI M, et al.Low dose native type II collagen prevents pain in a rat osteoarthritis model[J].BMC Musculoskeletal Disorders, 2013, 14:228.
[40] ASNAGLI H, MARTIRE D, BELMONTE N, et al.Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis[J].Arthritis Research & Therapy, 2014, 16(3):R115.
[41] LEÓN-LÓPEZ A, MORALES-PEÑALOZA A, MARTÍNEZ-JUÁREZ V M, et al.Hydrolyzed collagen-sources and applications[J].Molecules (Basel, Switzerland), 2019, 24(22):E4031.
[42] BELLO A E, OESSER S.Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:A review of the literature[J].Current Medical Research and Opinion, 2006, 22(11):2 221-2 232.
[43] OESSER S, ADAM M, BABEL W, et al.Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL)[J].The Journal of Nutrition, 1999, 129(10):1 891-1 895.
[44] WANG L, WANG Q, QIAN J, et al.Bioavailability and bioavailable forms of collagen after oral administration to rats[J].J Agric Food Chem, 2015, 63(14):3 752-3 756.
[45] SHIGEMURA Y, KUBOMURA D, SATO Y, et al.Dose-dependent changes in the levels of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysate ingestion[J].Food Chemistry, 2014, 159:328-332.
[46] ICHIKAWA S, MORIFUJI M, OHARA H, et al.Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate[J].International Journal of Food Sciences and Nutrition, 2010, 61(1):52-60.
[47] SKOV K, OXFELDT M, THGERSEN R, et al.Enzymatic hydrolysis of a collagen hydrolysate enhances postprandial absorption rate:A randomized controlled trial[J].Nutrients, 2019, 11(5):E1064.
[48] GAUZA-WODARCZYK M, KUBISZ L, WODARCZYK D.Amino acid composition in determination of collagen origin and assessment of physical factors effects[J].International Journal of Biological Macromolecules, 2017, 104:987-991.
[49] LI Y S, XIAO W F, LUO W, et al.Alterations of amino acid metabolism in osteoarthritis:Its implications for nutrition and health[J].Amino Acids, 2016, 48(4):907-914.
[50] OESSER S, SEIFERT J.Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen[J].Cell and Tissue Research, 2003, 311(3):393-399.
[51] SCHUNCK M, SCHULZE C H, OESSER S.p199 disparate efficacy of collagen hydrolysate and glucosamine on the extracellular matrix metabolism of articular chondrocytes[J].Osteoarthritis and Cartilage, 2006, 14:S114.
[52] DAR Q A, SCHOTT E M, CATHELINE S E, et al.Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis[J].PLoS One, 2017, 12(4):e0174705.
[53] BROERE F, WIETEN L, KLEIN KOERKAMP E I, et al.Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes[J].Journal of Immunology, 2008, 181(2):899-906.
[54] PAUL C, LESER S, OESSER S.Significant amounts of functional collagen peptides can be incorporated in the diet while maintaining indispensable amino acid balance[J].Nutrients, 2019, 11(5):E1079.
[55] LIAN C, WANG X, QIU X, et al.Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction[J].Bone Research, 2019, 7:8.
[56] 张慧琴, 霍乃蕊, 冀霞, 等.羊骨胶原肽对大鼠腹腔巨噬细胞免疫能力的影响[J].中国实验动物学报, 2021, 29(2):176-182.
ZHANG H Q, HUO N R, JI X, et al.Effect of sheep bone collagen peptide on immune function in rat peritoneal macrophages[J].Acta Laboratorium Animalis Scientia Sinica, 2021, 29(2):176-182.
[57] VAN DER KRAAN P M, VAN DEN BERG W B.Chondrocyte hypertrophy and osteoarthritis:Role in initiation and progression of cartilage degeneration? [J].Osteoarthritis and Cartilage, 2012, 20(3):223-232.
[58] CUI Z, CRANE J, XIE H, et al.Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone[J].Annls of the Rhenmatic Diseases, 2016, 75(9):1 714-1 721.
[59] VAN DE WATER E, OOSTERLINCK M, DUMOULIN M, et al.The preventive effects of two nutraceuticals on experimentally induced acute synovitis[J].Equine Veterinary Journal, 2017, 49(4):532-538.
[60] ISAKA S, SOMEYA A, NAKAMURA S, et al.Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model[J].Pharmaceutics, 2017, 13(6):2 699-2 706.
[61] MA C C, YU M X, HUANG Z J, et al.Oral administration of hydrolysates of cartilage extract in the prevention of osteoarthritis[J].Journal of Functional Foods, 2021, 78:104376.
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