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微生物合成低分子质量及寡聚透明质酸研究进展

  • 李宛莹 ,
  • 郑丽圆 ,
  • 喻林兵 ,
  • 宋馨 ,
  • 夏永军 ,
  • 艾连中 ,
  • 熊智强
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  • (上海理工大学 健康科学与工程学院,上海食品微生物工程研究中心,上海,200093)
硕士研究生(熊智强教授为通信作者,E-mail:xiongzq@hotmail.com)

收稿日期: 2022-12-15

  修回日期: 2023-01-11

  网络出版日期: 2023-04-28

基金资助

上海市科技创新行动计划国内合作项目(21015800300)

Progress in the synthesis of low molecular weight and oligomeric hyaluronic acid by microorganism

  • LI Wanying ,
  • ZHENG Liyuan ,
  • Yu Linbing ,
  • SONG Xin ,
  • Xia Yongjun ,
  • AI Lianzhong ,
  • XIONG Zhiqiang
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  • (Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)

Received date: 2022-12-15

  Revised date: 2023-01-11

  Online published: 2023-04-28

摘要

透明质酸(hyaluronic acid,HA)是由D-葡萄糖醛酸和N-乙酰氨基葡萄糖组成的天然线性黏多糖,具有良好的保湿性能,广泛应用于食品、医药和化妆品等行业。HA生物活性与分子质量高低密切相关,尤其低分子质量透明质酸(low molecular weight hyaluronic acid,LMW-HA)和寡聚透明质酸(oligomeric hyaluronic acid,o-HA)具有促进骨和血管生成、增强免疫调节和改善皮肤屏障受损等功效。尽管目前HA生产菌株的筛选和改造、发酵条件优化等方面取得了显著进展,然而大量报道主要是关于提高HA生产效率和高分子质量HA生产,较少关注LMW-HA和o-HA的生产。文章总结了两者生物合成途径及其工业应用,并探讨生物合成过程中分子质量调控策略,以期为LMW-HA和o-HA工业化生产提供依据。

本文引用格式

李宛莹 , 郑丽圆 , 喻林兵 , 宋馨 , 夏永军 , 艾连中 , 熊智强 . 微生物合成低分子质量及寡聚透明质酸研究进展[J]. 食品与发酵工业, 2023 , 49(7) : 302 -308 . DOI: 10.13995/j.cnki.11-1802/ts.034634

Abstract

Hyaluronic acid (HA) is a natural linear mucopolysaccharide composed of D-glucuronic acid and N-acetyl glucosamine, which has great moisturizing properties and is widely used in food, medicine, and cosmetic industries.The biological activity of HA is closely related to the molecular weight, especially low molecular weight hyaluronic acid (LMW-HA) and oligomeric hyaluronic acid (o-HA) have the effect of promoting bone and angiogenesis, enhancing immune regulation, and improving skin barrier damage.Although significant progress has been made in screening and modification of HA production strains and optimization of fermentation conditions, most reports focused on the increase of HA production efficiency and high molecular weight HA production and less attention on the production of LMW-HA and o-HA.This article summarizes the biosynthetic pathways and industrial applications of LMW-HA and o-HA, and investigates the molecular weight regulation strategies during the biosynthesis process, with a view to providing a basis for the industrial production of LMW-HA and o-HA.

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