[1] JAGGUPILLI A, HOWARD R, UPADHYAYA J D, et al.Bitter taste receptors:Novel insights into the biochemistry and pharmacology[J].The International Journal of Biochemistry & Cell Biology, 2016, 77:184-196.
[2] FRANK O, OTTINGER H, HOFMANN T.Characterization of an intense bitter-tasting 1H, 4H-quinolizinium-7-olate by application of the taste dilution analysis, a novel bioassay for the screening and identification of taste-active compounds in foods[J].Journal of Agricultural and Food Chemistry, 2001, 49(1):231-238.
[3] MENNELLA J A, BOBOWSKI N K.The sweetness and bitterness of childhood:Insights from basic research on taste preferences[J].Physiology & Behavior, 2015, 152:502-507.
[4] 毛青钟. 影响机械化黄酒中产生苦(涩)味物质的因素及控制[J].酿酒, 2001, 28(1):43-45.
MAO Q Z.Factors affecting bitter (astringent) flavor substances in mechanized yellow rice wine and their control[J].Liquor-making, 2001, 28(1):43-45.
[5] 杨国军. 黄酒中苦味物质及其来源探讨[J].酿酒, 2003, 30(3):44-46.
YANG G J.Discussion on bitter substances in yellow rice wine and their sources[J].Liquor-making, 2003, 30(3):44-46.
[6] 杨国军. 黄酒中的苦味物质及其来源探讨[J].食品与发酵工业, 2004, 30(2):87-90.
YANG G J.Discussion on bitter substances in yellow rice wine and their sources[J].Food and Fermentation Industries, 2004, 30(2):87-90.
[7] HOFMANN T, KRAUTWURST D, SCHIEBERLE P.Current status and future perspectives in flavor research:Highlights of the 11th wartburg symposium on flavor chemistry & biology[J].Journal of Agricultural and Food Chemistry, 2018, 66(10):2 197-2 203.
[8] HUFNAGEL J C, HOFMANN T.Quantitative reconstruction of the nonvolatile sensometabolome of a red wine[J].Journal of Agricultural and Food Chemistry, 2008, 56(19):9 190-9 199.
[9] HASHIZUME K, ITO T, SHIMOHASHI M, et al.Taste-guided fractionation and instrumental analysis of hydrophobic compounds in sake[J].Bioscience, Biotechnology, and Biochemistry, 2012, 76(7):1 291-1 295.
[10] ZHAO T F, NI D R, HU G Y, et al.6-(2-formyl-5-methyl-1 H-pyrrol-1-yl)hexanoic acid as a novel retronasal burnt aroma compound in soy sauce aroma-type Chinese Baijiu[J].Journal of Agricultural and Food Chemistry, 2019, 67(28):7 916-7 925.
[11] ZHAO T F, CHEN S, LI H Z, et al.Identification of 2-hydroxymethyl-3, 6-diethyl-5-methylpyrazine as a key retronasal burnt flavor compound in soy sauce aroma type Baijiu using sensory-guided isolation assisted by multivariate data analysis[J].Journal of Agricultural and Food Chemistry, 2018, 66(40):10 496-10 505.
[12] TOELSTEDE S, HOFMANN T.Sensomics mapping and identification of the key bitter metabolites in Gouda cheese[J].Journal of Agricultural and Food Chemistry, 2008, 56(8):2 795-2 804.
[13] HUFNAGEL J C, HOFMANN T.Orosensory-directed identification of astringent mouthfeel and bitter-tasting compounds in red wine[J].Journal of Agricultural and Food Chemistry, 2008, 56(4):1 376-1 386.
[14] 蒲云峰. 骏枣苦味物质鉴定及形成机理研究[D].杭州:浙江大学, 2019.
PU Y F.Identification of bitter compounds and its formation mechanism of jujube fruit(Z.jujuba.cv.Junzao)[D].Hangzhou:Zhejiang University, 2019.
[15] 赵腾飞, 陈双, 李华钟, 等.白酒难挥发组分中呈苦味三羟基十八烯酸的分离与鉴定[J].食品与发酵工业, 2018, 44(9):225-231.
ZHAO T F, CHEN S, LI H Z, et al.Isolation and identification of bitter-tasting trihydroxyoctadecenoic acids in Baijiu(Chinese liquor)[J].Food and Fermentation Industries, 2018, 44(9):225-231.
[16] 吴继红. 芝麻香型白酒中多肽的抗氧化活性及其对白酒风味影响的研究[D].广州:华南理工大学, 2018.
WU J H.Antioxidant activity of peptides from sesame flavor-type Baijiu and their interactions with aroma compounds[D].Guangzhou:South China University of Technology, 2018.
[17] 魏冬, 范文来, 徐岩.应用UPLC-Q-TOF-MS鉴定白酒酒糟中的水溶性多肽[J].食品与发酵工业, 2019, 45(5):203-207.
WEI D, FAN W L, XU Y.Identification of water-soluble peptides in distilled spent grains by UPLC-Q-TOF-MS[J].Food and Fermentation Industries, 2019, 45(5):203-207.
[18] 卢敏. 促酵母生长代谢活性肽的分离纯化与结构鉴定研究[D].广州:华南理工大学, 2017.
LU M.Purification and identification of active peptides that promote yeast growth and metabolism[D].Guangzhou:South China University of Technology, 2017.
[19] 周永婧. 小麦面筋蛋白源促酵母增殖与代谢活性肽的分离纯化与结构鉴定研究[D].广州:华南理工大学, 2018.
ZHOU Y J.Purification and identification of peptides with growth-and fermentation-promoting activity of brewer’s yeast from wheat gluten protein[D].Guangzhou:South China University of Technology, 2018.
[20] 瞿杰. 牡丹籽油脂的理化性质研究及抗氧化肽的分离鉴定[D].合肥:合肥工业大学, 2017.
QU J.Physicochemical properties of peony seed oil and isolation and identificantion of antioxidant peptide[D].Hefei:Hefei University of Technology, 2017.
[21] 王树英, 徐岩, 徐文琦, 等.中国黄酒与日本清酒氨基酸成份和成因研究与分析[J].酿酒, 1997, 24(6):10-11.
WANG S Y, XU Y, XU W Q, et al.Study and analysis on amino acid composition and causes of China yellow rice wine and Japanese sake[J].Liquor Making, 1997, 24(6):10-11.
[22] HASHIZUME K, OKUDA M, NUMATA M, et al.Bitter-tasting sake peptides derived from the N-terminus of the rice glutelin acidic subunit[J].Food Science and Technology Research, 2007, 13(3):270-274.
[23] HASHIZUME K, ITO T, IGARASHI S.Quantitation using a stable isotope dilution assay (SIDA) and thresholds of taste-active pyroglutamyl decapeptide ethyl esters (PGDPEs) in sake[J].Bioscience, Biotechnology, and Biochemistry, 2017, 81(3):426-430.
[24] MAEDA Y, OKUDA M, HASHIZUME K, et al.Analyses of peptides in sake mash:Forming a profile of bitter-tasting peptides[J].Journal of Bioscience and Bioengineering, 2011, 112(3):238-246.
[25] KIYONO T, HIROOKA K, YAMAMOTO Y, et al.Identification of pyroglutamyl peptides in Japanese rice wine (sake):Presence of hepatoprotective pyroGlu-Leu[J].Journal of Agricultural and Food Chemistry, 2013, 61(47):11 660-11 667.
[26] KANEKO S, KUMAZAWA K, NISHIMURA O.Isolation and identification of the umami enhancing compounds in Japanese soy sauce[J].Bioscience, Biotechnology, and Biochemistry, 2011, 75(7):1 275-1 282.
[27] SCHLICHTHERLE-CERNY H, AMADÒ R.Analysis of taste-active compounds in an enzymatic hydrolysate of deamidated wheat gluten[J].Journal of Agricultural and Food Chemistry, 2002, 50(6):1 515-1 522.
[28] GAZME B, BOACHIE R T, TSOPMO A, et al.Occurrence, properties and biological significance of pyroglutamyl peptides derived from different food sources[J].Food Science and Human Wellness, 2019, 8(3):268-274.
[29] COOMAN L, AERTS G, OVERMEIRE H, et al.Alterations of the profiles of iso-α-acids during beer ageing, marked instability of trans-iso-α-acids and implications for beer bitterness consistency in relation to tetrahydroiso-α-acids[J].Journal of the Institute of Brewing, 2000, 106(3):169-178.
[30] HASELEU G, INTELMANN D, HOFMANN T.Identification and RP-HPLC-ESI-MS/MS quantitation of bitter-tasting beta-acid transformation products in beer[J].Journal of Agricultural and Food Chemistry, 2009, 57(16):7 480-7 489.
[31] 郝俊光, 周月南, 尹花, 等.啤酒中源自酒花α-酸的苦味物质研究进展[J].食品与发酵工业, 2017, 43(12):232-240.
HAO J G, ZHOU Y N, YIN H, et al.Study on bitter compounds in beer originated from hop α acid[J].Food and Fermentation Industries, 2017, 43(12):232-240.
[32] INTELMANN D, HASELEU G, HOFMANN T.LC-MS/MS quantitation of hop-derived bitter compounds in beer using the ECHO technique[J].Journal of Agricultural and Food Chemistry, 2009, 57(4):1 172-1 182.
[33] RUDNITSKAYA A, NIEUWOUDT H H, MULLER N, et al.Instrumental measurement of bitter taste in red wine using an electronic tongue[J].Analytical and Bioanalytical Chemistry, 2010, 397(7):3 051-3 060.
[34] GLABASNIA A, HOFMANN T.Sensory-directed identification of taste-active ellagitannins in American (Quercus alba L.) and European oak wood (Quercus robur L.) and quantitative analysis in bourbon whiskey and oak-matured red wines[J].Journal of Agricultural and Food Chemistry, 2006, 54(9):3 380-3 390.
[35] SINDT L, GAMMACURTA M, WAFFO-TEGUO P, et al.Taste-guided isolation of bitter lignans from Quercus petraea and their identification in wine[J].Journal of Natural Products, 2016, 79(10):2 432-2 438.
[36] 毕静莹. 柑橘酒苦味物质及其控制技术研究[D].杨凌:西北农林科技大学, 2019.
BI J Y.Study on the bitter substances and its control technology of citrus wine[D].Yangling:Northwest A & F University, 2019.
[37] DRESEL M, DUNKEL A, HOFMANN T.Sensomics analysis of key bitter compounds in the hard resin of hops (Humulus lupulus L.) and their contribution to the bitter profile of Pilsner-type beer[J].Journal of Agricultural and Food Chemistry, 2015, 63(13):3 402-3 418.
[38] SUZUKI N, ITO T, HIROSHIMA K, et al.Formation of ethyl ferulate from feruloylated oligosaccharide by transesterification of rice koji enzyme under sake mash conditions[J].Journal of Bioscience and Bioengineering, 2016, 121(3):281-285.
[39] 孙志高, 黄学根, 焦必宁, 等.柑桔果实主要苦味成分的分布及橙汁脱苦技术研究[J].食品科学, 2005, 26(6):146-148.
SUN Z G, HUANG X G, JIAO B N, et al.Studied on the distributing of main bitter components in citrus fruit and the debittering technology of orange juice[J].Food Science, 2005, 26(6):146-148.
[40] 梁泽建, 蒲彪, 彭训亮, 等.活性硅酸镁对柑桔汁中柠檬苦素吸附的研究[J].食品工业科技, 2007, 28(9):132-134.
LIANG Z J, PU B, PENG X L, et al.Study on the adsorption of limonin in citrus juice by activated magnesium silicate[J].Science and Technology of Food Industry, 2007, 28(9):132-134.
[41] HASHIZUME K, ITO T, SHIMOHASHI M, et al.Ferulic acid and ethyl ferulate in sake:Comparison of levels between sake and mirin and analysis of their sensory properties[J].Food Science and Technology Research, 2013, 19(4):705-709.
[42] 李萍. 大豆肽脱苦及其生理功能的研究[D].济南:济南大学, 2014.
LI P.Study on soybean peptide debitterizing and physiological function[D].Jinan:University of Jinan, 2014.
[43] 李睿晓. 柚子酒的微生物脱苦技术研究[D].重庆:西南大学, 2010.
LI R X.Study on debittering technology with microorganism of grapefruit wine[D].Chongqing:Southwest University, 2010.
[44] 刘伯业. 小麦蛋白低苦味肽的制备及其脱苦机理研究[D].无锡:江南大学, 2017.
LIU B Y.Study on the preparation of low-bitterness peptide powders from gluten and debittering mechanism[D].Wuxi:Jiangnan University, 2017.
[45] HILLMANN H, HOFMANN T.Quantitation of key tastants and re-engineering the taste of Parmesan cheese[J].Journal of Agricultural and Food Chemistry, 2016, 64(8):1 794-1 805.
[46] 芮鸿飞, 张晓瑜, 刘兴泉, 等.PITC柱前衍生-反相高效液相色谱法测定黄酒中游离氨基酸和生物胺[J].食品科学, 2016, 37(8):159-163.
RUI H F, ZHANG X Y, LIU X Q, et al.Simultaneous determination of free amino acids and biogenic amines in Chinese rice wine by RP-HPLC with pre-column phenylisothiocyanate(PITC)derivatization[J].Food Science, 2016, 37(8):159-163.
[47] 张辉, 袁军川, 毛严根, 等.机制黄酒酿造生产过程中氨基酸变化研究[J].酿酒科技, 2009(2):37-39.
ZHANG H, YUAN J C, MAO Y G, et al.Research on the change of amino acid content in mechanized production of yellow rice wine[J].Liquor-Making Science & Technology, 2009(2):37-39.
[48] 齐小慧, 孙军勇, 谢广发, 等.蛋白质对黄酒品质影响的研究进展[J].食品与发酵工业, 2018, 44(3):273-279.
QI X H, SUN J Y, XIE G F, et al.Effect of protein on quality of Chinese rice wine[J].Food and Fermentation Industries, 2018, 44(3):273-279.
[49] 孔令琼, 管政兵, 陆健, 等.绍兴黄酒成品麦曲中微生物胞外酶的双向电泳技术的建立[J].食品与生物技术学报, 2011, 30(3):453-457.
KONG L Q, GUAN Z B, LU J, et al.Establishment of a two-dimensional electrophoresis protocol for extracellular enzymes excreted by microorganisms from Shaoxing rice wine wheat Qu[J].Journal of Food Science and Biotechnology, 2011, 30(3):453-457.
[50] 冯红霞, 陆兆新, 尤华.苦味肽的形成及脱苦方法的研究[J].食品科学, 2002, 23(5):151-154.
FENG H X, LU Z X, YOU H.Study on forming mechanism and debittering methods of bitter peptides[J].Food Science, 2002, 23(5):151-154.
[51] NEY K H.Voraussage der bitterkeit von peptiden aus deren aminosáurezu-sammensetzung[J].Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung, 1971, 147(2):64-68.
[52] LUO Y, KONG L H, XUE R Q, et al.Bitterness in alcoholic beverages:The profiles of perception, constituents, and contributors[J].Trends in Food Science & Technology, 2020, 96:222-232.
[53] KIM H O, LI-CHAN E C Y.Quantitative structure-activity relationship study of bitter peptides[J].Journal of Agricultural and Food Chemistry, 2006, 54(26):10 102-10 111.
[54] LU Z D, XIE G F, WU D H, et al.Isolation and identification of the bitter compound from Huangjiu[J].Food Chemistry, 2021, 349:129133.
