食品与发酵工业 >

2023 , Vol. 49 >Issue 10: 306 - 313

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.032462

综述与专题评论

表面功能化银纳米粒子(Ag NPs)在生物传感器构建中的应用

  • 地力努·库尔班 ,
  • 陈菲 ,
  • 王德萍 ,
  • 秦亚楠 ,
  • 邢军 ,
  • 张民伟
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  • (新疆大学 生命科学与技术学院,新疆 乌鲁木齐,830017)
第一作者:地力努·库尔班(硕士研究生)和陈菲(博士研究生)为共同第一作者(张民伟副教授和邢军讲师为共同通信作者,E-mail:zhang78089680@sina.com;1540517550@qq.com)

收稿日期: 2022-05-26

  修回日期: 2022-08-20

  网络出版日期: 2023-06-13

基金资助

国家自然科学基金(31960496)

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Application of surface functionalized silver nanoparticles (Ag NPs) in biosensors construction

  • DILINU Kuerban ,
  • CHEN Fei ,
  • WANG Deping ,
  • QIN Yanan ,
  • XING Jun ,
  • ZHANG Minwei
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  • (College Life Science and Technology, Xinjiang University, Urumqi 830017, China)

Received date: 2022-05-26

  Revised date: 2022-08-20

  Online published: 2023-06-13

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摘要

银纳米粒子(silver nanoparticles,Ag NPs)具有消光系数较高、比表面积大、合成成本低、表面可修饰等特性,被广泛用作比色探针构建生物传感器用于食品、药品、环境中危害因子的检测。Ag NPs的表面状态影响生物传感器的选择性、灵敏度、稳定性等,因此,对Ag NPs进行有效地表面功能化尤为重要。采用共价键合功能化、非共价键合功能化或掺杂复合功能化等不同的修饰方法,提高了Ag NPs的稳定性和分析适用性,从而扩宽Ag NPs的应用和研究。该文重点介绍了Ag NPs的表面物理修饰法和化学修饰法以及表面功能化后的Ag NPs在构建荧光生物传感器、比色生物传感器、电化学免疫生物传感器、表面等离子体共振生物传感器中的应用原理,以期为纳米生物传感器的研究发展提供参考。

关键词： 功能化银纳米粒子(Ag NPs); 表面功能化; 生物传感器; 食品安全

本文引用格式

地力努·库尔班 , 陈菲 , 王德萍 , 秦亚楠 , 邢军 , 张民伟 . 表面功能化银纳米粒子(Ag NPs)在生物传感器构建中的应用[J]. 食品与发酵工业, 2023 , 49(10) : 306 -313 . DOI: 10.13995/j.cnki.11-1802/ts.032462

Abstract

Silver nanoparticles (Ag NPs) exhibit high extinction coefficient, large specific surface area, low cost and surface functionalization, which are widely used to build biosensor for the detection of hazard factors in food, drugs and environment. The selectivity, sensitivity, and stability of the Ag NPs-based biosensors are strongly dependent the surface of Ag NPs. Currently, the surface of Ag NPs could be modified via covalently bonded, non-covalently bonded, or doped compound functionalization to improve the stability and analytical applicability of Ag NPs. In this review, the surface functionalization of Ag NPs is comprehensively summarized. More importantly, the application principle of functionalized Ag NPs in the construction of fluorescent biosensor, colorimetric biosensor, electrochemical immune biosensor, and surface plasmon resonance biosensor are highlighted in detail. The review provides effective guidance on how to construct nano-biosensors.

Key words： functionalized silver nanoparticles (Ag NPs); surface functionalization; biosensor; food safety

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