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猴头菇多糖结构及调节肠道菌群作用研究进展

  • 朱佳敏 ,
  • 武艺 ,
  • 赵琳静 ,
  • 沈凡妮 ,
  • 曹婷苇 ,
  • 刘晓会 ,
  • 刘锡建 ,
  • 李洪森 ,
  • 李琦 ,
  • 冯美卿
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  • 1(上海工程技术大学 化学化工学院,上海,201620)
    2(上海雷允上药业有限公司,上海,201401)
    3(复旦大学 药学院,上海,201203)
朱佳敏(硕士研究生)和武艺(硕士研究生)为共同第一作者(赵琳静副教授为通信作者,E-mail:ljzhao@sues.edu.cn)

收稿日期: 2023-03-23

  修回日期: 2023-04-11

  网络出版日期: 2023-08-30

基金资助

国家自然科学基金项目 (31701032);上海市大学生创新训练项目(cs2104007)

Structures and effects of Hericium erinaceus polysaccharide on regulating gut microbiota: A review

  • ZHU Jiamin ,
  • WU Yi ,
  • ZHAO Linjing ,
  • SHEN Fanni ,
  • CAO Tingwei ,
  • LIU Xiaohui ,
  • LIU Xijian ,
  • LI Hongsen ,
  • LI Qi ,
  • FENG Meiqing
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  • 1(College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China)
    2(Shanghai Leiyunshang Pharmaceutical Co. Ltd., Shanghai 201401, China)
    3(School of Pharmacy, Fudan University, Shanghai 201203, China)

Received date: 2023-03-23

  Revised date: 2023-04-11

  Online published: 2023-08-30

摘要

猴头菇多糖是从食药真菌猴头菇(Hericium erinaceus)的子实体、菌丝体或发酵培养液中提取的一类活性大分子。近年来,关于猴头菇多糖通过改变肠道菌群来调节免疫、缓解炎症性肠病、影响神经系统及代谢性疾病的研究日益增多。猴头菇多糖可通过促进肠道益生菌增殖、抑制致病菌生长、增加短链脂肪酸生成、增强肠道免疫及激活特定信号通路发挥健康促进作用。这些生物活性与猴头菇多糖的结构有关。该文总结了不同来源猴头菇多糖的结构特征及对肠道菌群多样性的影响,综述了猴头菇多糖通过调节肠道菌群促进健康的积极作用及可能机制,并列举了其在多领域的应用和开发前景,为猴头菇多糖调控肠道微生物稳态的深入探索提供了理论依据,也为猴头菇多糖类益生元制剂的开发利用提供了参考。

本文引用格式

朱佳敏 , 武艺 , 赵琳静 , 沈凡妮 , 曹婷苇 , 刘晓会 , 刘锡建 , 李洪森 , 李琦 , 冯美卿 . 猴头菇多糖结构及调节肠道菌群作用研究进展[J]. 食品与发酵工业, 2023 , 49(14) : 311 -320 . DOI: 10.13995/j.cnki.11-1802/ts.035592

Abstract

Hericium erinaceus polysaccharide is a kind of biological macromolecule extracted from the fruiting body, mycelium or fermentation broth of the culinary and medicinal mushroom of H. erinaceus. In recent years, more and more studies have shown the roles of H. erinaceus polysaccharide in immune regulation, alleviating inflammatory bowel disease, and improving nervous system and metabolic diseases by mediating gut microbiota. H. erinaceus polysaccharide possess a variety of health promoting effects by enriching the intestinal probiotics, inhibiting the growth of pathogenic bacteria, improving the production of short-chain fatty acids, enhancing intestinal immune responses, and activating the specific signaling pathways. These biological activities are related to the structure of H. erinaceus polysaccharide. This review summarized the structural characteristics of H. erinaceus polysaccharide from different sources and the influence on gut microbiota diversity, the effects and potential mechanism on promoting health by regulating intestinal flora, as well as the applications and development prospects in various fields. It could provide a theoretical basis for further study of H. erinaceus polysaccharides on gut microbial homeostasis, and give a reference for developing and utilizing H. erinaceus polysaccharides as promising prebiotics.

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