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疏水化多糖自聚集系统的制备方法及其形成机制分析

  • 李红 ,
  • 唐新 ,
  • 汪小刚 ,
  • 王勇德 ,
  • 赵博 ,
  • 吴振
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  • 1(重庆市食品药品检验检测研究院,国家市场监管重点实验室(调味品监管技术),重庆,401121)
    2(重庆市中药研究院,中药健康学重庆市重点实验室,重庆,400065)
第一作者:硕士,高级工程师(吴振研究员为通信作者,E-mail:wuzhen985@126.com)

收稿日期: 2022-09-23

  修回日期: 2022-11-22

  网络出版日期: 2024-03-15

基金资助

重庆市技术创新与应用发展专项重点项目(cstc2021jscx-dxwtBX0011,cstc2021jscx-gksb-N0037,CSTB2022TIAD-KPX0094);重庆市科卫联合医学科研项目(2023MSXM159);重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0001);重庆市基本科研业务费计划项目(jbky20210009)

Analysis of preparation methods and formation mechanisms of hydrophobized polysaccharide-based self-assembly systems

  • LI Hong ,
  • TANG Xin ,
  • WANG Xiaogang ,
  • WANG Yongde ,
  • ZHAO Bo ,
  • WU Zhen
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  • 1(National Key Laboratory of Market Supervision (Condiment Supervision Technology), Chongqing Institute for Food and Drug Control, Chongqing 401121, China)
    2(Chongqing Academy of Chinese Materia Medica, Chongqing Key Laboratory of Chinese Medicine and Health Science, Chongqing 400065, China)

Received date: 2022-09-23

  Revised date: 2022-11-22

  Online published: 2024-03-15

摘要

天然多糖作为一种安全、无毒和有效的递送载体材料近年来得到广泛的关注,但两亲性和聚集能力缺乏、空间结构难控及易失稳等缺点制约了其应用,而适度疏水化处理能使多糖分子在高级结构上发生巨变,赋予其更多的结构调控性和应用可能性。该文系统梳理了近5年疏水化多糖的研究进展,主要总结了通过疏水化多糖制备各种自聚集系统(主要包括胶束、反胶束、聚合物囊泡和水凝胶等)的方法路径,分析了其形成的前提条件和分子机制。结果发现可通过选择疏水化多糖种类及其制备方法定制其自聚集系统的结构、粒径大小和形貌等特性,以期实现特定场所应用,为疏水化多糖自聚集体及其递送系统的设计、制备和应用提供基础与依据。

本文引用格式

李红 , 唐新 , 汪小刚 , 王勇德 , 赵博 , 吴振 . 疏水化多糖自聚集系统的制备方法及其形成机制分析[J]. 食品与发酵工业, 2024 , 50(3) : 336 -344 . DOI: 10.13995/j.cnki.11-1802/ts.033748

Abstract

As safe, non-toxic, and effective delivery carrier materials, natural polysaccharides have been widely studied in recent years, but lack of amphiphilicity and self-assembly ability and uncontrolled and unstable spatial structures limit their application. The high-level structures of polysaccharides can be changed greatly by suitable hydrophobic modification, giving more possibilities for their structural regulation and application. The research progress of hydrophobized polysaccharides (HPs) in the last five years was summarized. The preparation methods of various delivery systems (micelles, reverse micelles, polymersomes, hydrogels, etc.) formed by HPs molecules were mainly summarized. Their preconditions and molecular mechanisms were analyzed. Results showed that the structures, sizes, and morphologies of HPs self-aggregation systems could be customized by selecting the types and preparation methods of HPs to achieve specific applications. It provides the foundation and basis for the design, preparation, and application of HPs self-aggregates and their delivery systems.

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