[1] PANGESTUTI R, ARIFIN Z.Medicinal and health benefit effects of functional sea cucumbers[J].Journal of Traditional and Complementary Medicine, 2018, 8(3):341-351.
[2] 廖玉麟. 我国的海参[J].生物学通报, 2001, 36(9):1-3;47.
LIAO Y L.Sea cucumber in China[J].Bulletin of Biology, 2001, 36(9):1-3;47.
[3] 韩秋菊, 马宏飞.海参多糖的提取与纯化研究[J].安徽农业科学, 2012, 40(14):8071-8072;8074.
HAN Q J, MA H F.Extraction and purification of polysaccharides in sea cucumber[J].Journal of Anhui Agricultural Sciences, 2012, 40(14):8071-8072;8074.
[4] 冯骏. 海参多糖的分离纯化与化学组成的研究[D].厦门:集美大学, 2014.
FENG J.Study on isolation, purification and chemical component analysis of polysaccharides fromsea cucumber[D].Xiamen:Jimei University, 2014.
[5] LI C, NIU Q F, LI S J, et al.Fucoidan from sea cucumber Holothuria polii:Structural elucidation and stimulation of hematopoietic activity[J].International Journal of Biological Macromolecules, 2020, 154:1123-1131.
[6] GONG P X, WU Y C, LIU Y, et al.Structure and hypoglycemic effect of a neutral polysaccharide isolated from sea cucumber Stichopus japonicus[J].International Journal of Biological Macromolecules, 2022, 216:14-23.
[7] 韩慧敏, 谢安, 罗杰英.海参多糖提取工艺研究[J].湖南中医杂志, 2000, 16(1):56-57.
HAN H M, XIE A, LUO J Y.Study on extraction technology of polysaccharide from sea cucumber[J].Hunan Journal of Traditional Chinese Medicine, 2000, 16(1):56-57.
[8] 陈发河, 李真, 吴光斌.海地瓜多糖和多肽提取纯化工艺及抗氧化活性[J].集美大学学报(自然科学版), 2018, 23(2):105-118.
CHEN F H, LI Z, WU G B.Study on the extraction and antioxidant activities of polysaccharides and polypeptides from Acaudina molpadioides(semper)[J].Journal of Jimei University (Natural Science), 2018, 23(2):105-118.
[9] 徐逯, 叶立斌, 于平, 等.东海海参多糖酶解提取工艺优化[J].食品科学, 2010, 31(20):61-66.
XU L, YE L B, YU P, et al.Optimization of enzymatic polysaccharide extraction from Acaudina molpadioides semper by response surface methodology[J].Food Science, 2010, 31(20):61-66.
[10] MOU J J, LI Q, QI X H, et al.Structural comparison, antioxidant and anti-inflammatory properties of fucosylated chondroitin sulfate of three edible sea cucumbers[J].Carbohydrate Polymers, 2018, 185:41-47.
[11] 展学孔, 周海妹, 马小花, 等.海参多糖提取新工艺[J].中国实验方剂学杂志, 2011, 17(15):40-42.
ZHAN X K, ZHOU H M, MA X H, et al.New extraction technology of polysaccharide from sea cucumber[J].Chinese Journal of Experimental Traditional Medical Formulae, 2011, 17(15):40-42.
[12] LI X M, LUO L, CAI Y, et al.Structural elucidation and biological activity of a highly regular fucosylated glycosaminoglycan from the edible sea cucumber Stichopus herrmanni[J].Journal of Agricultural and Food Chemistry, 2017, 65(42):9315-9323.
[13] HE W T, SUN H H, SU L J, et al.Structure and anticoagulant activity of a sulfated fucan from the sea cucumber Acaudina leucoprocta[J].International Journal of Biological Macromolecules, 2020, 164:87-94.
[14] 王远红, 吕志华, 姜廷福, 等.梅花参中多糖提取工艺及含量测定的研究[J].中国海洋大学学报(自然科学版), 2005, 35(6):987-990.
WANG Y H, LV Z H, JIANG T F, et al.Extraction and determination of polysaccharides in the holothutia[J].Journal of Ocean University of Qingdao, 2005, 35(6):987-990.
[15] WANG J J, SHI S, LI F F, et al.Physicochemi-cal properties and antioxidant activity of polysaccharides obtained from sea cucumber gonads via ultrasound-assisted enzymatic techniques[J].LWT-Food Science and Technology, 2022, 160:113307.
[16] 王庆芬. 刺参中多糖的提取分离、结构表征及其核苷类物质的分析[D].福州:福建医科大学, 2017.
WANG Q F.Extraction, separation, structural characterization of polysaccharide and analysis on nucleoside in Stichopus japonicus[D].Fuzhou:Fujian Medical University, 2017.
[17] 王婧媛, 王联珠, 孙晓杰, 等.海参加工工艺、营养成分及活性物质研究进展[J].食品安全质量检测学报, 2018, 9(11):2749-2755.
WANG J Y, WANG L Z, SUN X J, et al.Research progress on processing technology, nutritive components and active substances of sea cucumber[J].Journal of Food Safety & Quality, 2018, 9(11):2749-2755.
[18] 于双, 李双双, 宋志远, 等.海参多糖提取 分离及纯化的研究概述[J].农产品加工, 2022(7):80-83;88.
YU S, LI S S, SONG Z Y, et al.Research on extraction separation purification methods of sea cucumber polysaccharides[J].Farm Products Processing, 2022(7):80-83;88.
[19] 汪国威. 海南玉足海参的化学成分研究[D].海口:海南大学, 2018.
WANG G W.Studies on the chemical constituents of sea cucumber in Yuzu, Hainan[D].Haikou:Hainan University, 2018.
[20] YUAN Q X, LI H, WANG Q, et al.Deaminative-cleaved S.monotuberculatus fucosylated glycosaminoglycan:Structural elucidation and anticoagulant activity[J].Carbohydrate Polymers, 2022, 298:120072.
[21] 宋思媛, 李美琪, 王泽旭, 等.海参多糖对小鼠肠道菌群紊乱的恢复作用[J].中国微生态学杂志, 2019, 31(9):1 023-1026; 1033.
SONG S Y, LI M Q, WANG Z X, et al. Restoration effect of sea cucumber polysaccharides on intestinal microbiota disorder in mice[J]. Chinese Journal of Microecology, 2019, 31(9):1023-1026; 1033.
[22] 巫若子. 紫米花青素稳定性及应用研究进展[J].印染助剂, 2022, 39(10):7-10.
WU R Z.Research progress on the stability and application of purple rice anthocyanin[J].Textile Auxiliaries, 2022, 39(10):7-10.
[23] 李哲斌. 芋头多糖提取纯化、结构表征及生物活性研究进展[J].食品与发酵工业, 2023, 49(24):354-360.
LI Z B.Research progress on extraction, purification, structure characterization, and biological activity of taro polysaccharides[J].Food and Fermentation Industries, 2023, 49(24):354-360.
[24] 张军瑞, 陈健.木瓜蛋白酶酶解白底辐肛参提取多糖的研究[J].现代食品科技, 2009, 25(5):542-545.
ZHANG J R, CHEN J.Papain-catalyzed hydrolysis of Actinopyga mauritiana for mucopolysaccharide preparation[J].Modern Food Science and Technology, 2009, 25(5):542-545.
[25] 宿玮, 王彦超, 张翠玉, 等.海地瓜多糖脱色工艺研究[J].离子交换与吸附, 2011, 27(6):521-529.
SU W, WANG Y C, ZHANG C Y, et al.Study on decolorization technology of polysaccharide from Acaudina molpadioides[J].Ion Exchange and Adsorption, 2011, 27(6):521-529.
[26] 钮婧杰, 孙延平, 李霄, 等.树脂在中药多糖脱色工艺中的研究进展[J].化学工程师, 2021, 35(1):48-51.
NIU J J, SUN Y P, LI X, et al.Research progress of microporous resin in decolorization of polysaccharides from traditional Chinese medicine[J].Chemical Engineer, 2021, 35(1):48-51.
[27] 韩伟, 黄兮, 张玲玲, 等.中药多糖的提取、分离纯化及分析方法的研究进展[J].机电信息, 2012(14):19-25.
HAN W, HUANG X, ZHANG L L, et al.Advances in the extraction, isolation, purification and assay methods of polysaccharides in Chinese traditional medicine[J].Mechanical and Electrical Information, 2012(14):19-25.
[28] 朱启源. 两种海参多糖组分的制备及其改善大鼠2型糖尿病作用研究[D].广州:华南理工大学, 2020.
ZHU Q Y.Preparation of two sea cucumber polysaccharide fractions and their ameliorative effects on type 2 diabetes in rats[D].Guangzhou:South China University of Technology, 2020.
[29] 高岳. 不同产地刺参多糖的分离纯化及其组分含量的研究[D].大连:大连海洋大学, 2015.
GAO Y.Purification of polysaccharides and analysis of their contents and compositions in sea cucumbers(Apostichopus japonicas) from four origins[D].Dalian:Dalian Ocean University, 2015.
[30] 朱俊友, 李志佳, 董赵微, 等.香菇多糖提取、结构和生物活性的研究进展[J].河南工业大学学报(自然科学版), 2022, 43(5):125-136.
ZHU J Y, LI Z J, DONG Z W, et al.Research progress of extraction, structure, and biological activity of lentinan[J].Journal of Henan University of Technology (Natural Science Edition), 2022, 43(5):125-136.
[31] CHANG Y G, HU Y F, YU L, et al.Primary structure and chain conformation of fucoidan extracted from sea cucumber Holothuria tubulosa[J].Carbohydrate Polymers, 2016, 136:1091-1097.
[32] GONG P X, LI Q Y, WU Y C, et al.Structural elucidation and antidiabetic activity of fucosylated chondroitin sulfate from sea cucumber Stichopus japonicas[J].Carbohydrate Polymers, 2021, 262:117969.
[33] NIELSEN S S.Phenol-Sulfuric Acid Method for Total Carbohydrates[M]//NIELSEN SS.Food Analysis Laboratory Manual.Boston, MA:Springer, 2010:47-53.
[34] 罗素菜, 张海江.王不留行药材中多糖含量测定研究[J].亚太传统医药, 2021, 17(11):47-50.
LUO S C, ZHANG H J.Study on the determination of polysaccharide content in Semen vaccaria[J].Asia-Pacific Traditional Medicine, 2021, 17(11):47-50.
[35] 焦健, 朱振军, 佟志晏, 等.HPLC-MS/MS法分析刺参及其制品中海参多糖的含量[J].中国渔业质量与标准, 2020, 10(5):12-17.
JIAO J, ZHU Z J, TONG Z Y, et al.Quantification of sea cucumber polysaccharide in Apostichopus japonicus and its relevant products[J].Chinese Fishery Quality and Standards, 2020, 10(5):12-17.
[36] 刘芬, 孙晓杰, 朱文嘉, 等.海参中单糖检测方法的建立及含量测定[J].渔业科学进展, 2018, 39(2):177-182.
LIU F, SUN X J, ZHU W J, et al.Establishment and determination of monosaccharide in sea cucumber[J].Progress in Fishery Sciences, 2018, 39(2):177-182.
[37] 顾兴宇, 白光辉, 刘璐, 等.海参多糖结构表征的研究进展[J].中国海洋药物, 2023, 42(1):66-75.
GU X Y, BAI G H, LIU L, et al.Research progress on structural characterization of sea cucumber polysaccharide[J].Chinese Journal of Marine Drugs, 2023, 42(1):66-75.
[38] ZHENG W Q, ZHOU L T, LIN L S, et al.Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumber Pattalus mollis[J].Marine Drugs, 2019, 17(4):198.
[39] LUO L, WU M Y, XU L, et al.Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers[J].Marine Drugs, 2013, 11(12):399-417.
[40] 杨东达.海参内脏多糖的分离、结构鉴定、免疫活性及其应用研究[D].泉州:华侨大学, 2020.
YANG D D.Study on isolation, structure identification, immune activity and application of polysaccharides from sea cucumber viscera[D].Quanzhou:Huaqiao University, 2020.
[41] 王婷, 刘京熙, 张健, 等.海参精多糖提取工艺优化及其体外抗肿瘤活性[J].食品工业科技, 2016, 37(17):68-74.
WANG T, LIU J X, ZHANG J, et al.Optimization of extraction of sea cucumber sperm polysaccharide and its antitumor activity in vitro[J].Science and Technology of Food Industry, 2016, 37(17):68-74.
[42] 卢战辉, 白阳秋, 孙趁意, 等.海参多糖调控JAK2/STAT3/survivin通路对肝癌细胞增殖和凋亡的影响[J].中国普外基础与临床杂志, 2022, 29(7):875-880.
LU Z H, BAI Y Q, SUN C Y, et al.Effects of sea cucumber polysaccharide regulating JAK2/STAT3/survivin pathway on proliferation and apoptosis of hepatocellular carcinoma cells[J].Chinese Journal of Bases and Clinics in General Surgery, 2022, 29(7):875-880.
[43] 李天, 刘一帆, 周东梅, 等.海参多糖抑制人肾癌细胞A498的生长转移作用机制[J].基因组学与应用生物学, 2020, 39(3):1344-1350.
LI T, LIU Y F, ZHOU D M, et al.Mechanism of the effect of sea cucumber polysaccharide on inhibiting the growth and metastasis of human RCC A498 cells[J].Genomics and Applied Biology, 2020, 39(3):1344-1350.
[44] 张晓媛. 海参多糖联合放疗对人肺腺癌A549细胞系的增殖抑制及促凋亡作用研究[D].青岛:青岛大学, 2019.
ZHANG X Y.Combination of holothurian glycosaminoglycan and radiation has synergistically inhibitory effects on human lung adenocarcinoma A549[D].Qingdao:Qingdao University, 2019.
[45] 王静杰, 钟强, 董春晖, 等.海参多糖生物学活性及其作用机制研究进展[J].食品科学, 2021, 42(23):370-380.
WANG J J, ZHONG Q, DONG C H, et al.Recent progress in the biological activity and mechanism of action of sea cucumber polysaccharides[J].Food Science, 2021, 42(23):370-380.
[46] GAO N, CHEN R, MOU R R, et al.Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata[J].International Journal of Biological Macromolecules, 2020, 164:3421-3428.
[47] NING Z M, WANG P, ZUO Z C, et al.A Fucan sulfate with pentasaccharide repeating units from the sea cucumber Holothuria floridana and its anticoagulant activity[J].Marine Drugs, 2022, 20(6):377.
[48] 张哲娴. 玉足海参(Holothuria leucospilota)多糖的化学结构与抗凝活性研究[D].武汉:中南民族大学, 2021.
ZHANG Z X.Studies on the chemical structure and anticoagulant activity of polysaccharides from Holothuria leucospilota[D].Wuhan:Central South University for Nationalities, 2021.
[49] ZHU Y J, TIAN Y Y, WANG N, et al.Structure-function relationship analysis of fucoidan from sea cucumber (Holothuria tubulosa) on ameliorating metabolic inflammation[J].Journal of Food Biochemistry, 2021, 45(1):e13500.
[50] 张帅. 刺参岩藻聚糖硫酸酯对RAW264.7细胞炎症和自噬的影响[D].杨凌:西北农林科技大学, 2021.
ZHANG S.Effects of fucoidan from Stichopus japonicus on inflammation and autophagy of RAW264.7 cells[D].Yangling:Northwest A & F University, 2021.
[51] 袁义琼. 玉足海参多糖对大鼠高脂血症的缓解作用及机制研究[D].海口:海南大学, 2020.
YUAN Y Q.Study on the alleviative effect and mechanism of polysaccharides from sea cucumber of Yuzu on hyperlipidemia in rats[D].Haikou:Hainan University, 2020.
[52] 李启冬. 海参肠壁硫酸软骨素的结构解析和活性研究[D].哈尔滨:哈尔滨工业大学, 2021.
LI Q D.Structure analysis and activity study of chondroitin sulfate from intestinal wall of sea cucumber[D].Harbin:Harbin Institute of Technology, 2021.
[53] GAO L, XU C, TAO X L, et al.Structure elucidation of Fucan sulfate from sea cucumber Holothuria fuscopunctata through a bottom-up strategy and the antioxidant activity analysis[J].International Journal of Molecular Sciences, 2022, 23(9):4488.
[54] WANG W L, MAO H, LI S J, et al.Branched chondroitin sulfate oligosaccharides derived from the sea cucumber Acaudina molpadioides stimulate neurite outgrowth[J].Marine Drugs, 2022, 20(10):653.
[55] 冯巧巧, 谢纪珍, 樊红延, 等.低分子量海参多糖胶囊对小鼠酒精性肝损伤的保护作用[J].卫生研究, 2018, 47(1):146-147.
FENG Q Q, XIE J Z, FAN H Y, et al.Protective effect of low molecular weight sea cucumber polysaccharide capsule on alcoholic liver injury in mice[J].Journal of Hygiene Research, 2018, 47(1):146-147.
[56] LI G, ZHOU Y, YANG W Y, et al.Inhibitory effects of sulfated polysaccharides from the sea cucumber Cucumaria frondosa against Aβ40 aggregation and cytotoxicity[J].ACS Chemical Neuroscience, 2021, 12(11):1854-1859.
[57] ZHU Z J, ZHU B W, SUN Y J, et al.Sulfated polysaccharide from sea cucumber and its depolymerized derivative prevent obesity in association with modification of gut microbiota in high-fat diet-fed mice[J].Molecular Nutrition & Food Research, 2018, 62(23):e1800446.
[58] LI J H, LI S, YAN L F, et al.Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation:Importance of sulfation pattern and molecular size[J].European Journal of Medicinal Chemistry, 2017, 139:191-200.
[59] WU N, YE X Q, GUO X, et al.Depolymerization of fucosylated chondroitin sulfate from sea cucumber, Pearsonothuria graeffei, via 60Co irradiation[J].Carbohydrate Polymers, 2013, 93(2):604-614.
[60] CHEN S G, LI G Y, WU N, et al.Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates[J].Biochimica et Biophysica Acta (BBA)-General Subjects, 2013, 1830(4):3054-3066.