综述与专题评论

基于文献计量分析益生菌微胶囊化研究现状及发展趋势

  • 黄镇宇 ,
  • 徐磊 ,
  • 孙培龙 ,
  • 杨开 ,
  • 蔡铭 ,
  • 王舰
展开
  • (浙江工业大学 食品科学与工程学院,浙江 杭州,310014)
第一作者:本科生(蔡铭教授与王舰副教授为共同通信作者,E-mail:caiming@zjut.edu.cn;wangjian1926@zjut.edu.cn)

收稿日期: 2023-04-23

  修回日期: 2023-06-07

  网络出版日期: 2024-05-09

基金资助

浙江省科技攻关计划项目(2023C02040,2022C02041);浙江省自然科学基金项目(LQ23C200013)

A bibliometrics analysis of the current situation and development trend of probiotic microencapsulation research

  • HUANG Zhenyu ,
  • XU Lei ,
  • SUN Peilong ,
  • YANG Kai ,
  • CAI Ming ,
  • WANG Jian
Expand
  • (Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China)

Received date: 2023-04-23

  Revised date: 2023-06-07

  Online published: 2024-05-09

摘要

益生菌产品对维护肠道健康的重要性不断被揭示,但无论是加工、贮藏、运输中的物理损伤还是摄入之后胃酸、胆汁盐等的胁迫,都会导致益生菌活力损失。为解决这些问题,利用微胶囊技术对益生菌进行包埋已经成为重要议题。该研究借助CiteSpace6.1.R6、VOSviewer1.6.19和Bibliometrix等文献计量工具,对1 438篇中英文文献进行了分布特征分析。结果显示,益生菌微胶囊化研究正处于高速发展期,中国发文量领先,展现了未来发展的巨大潜力。包埋材料正在从壳聚糖与藻酸盐为主走向多元化发展,喷雾干燥技术取代冷冻干燥技术成为最常使用的微胶囊化手段。同时,各类生物活性材料的应用愈发频繁,多酚与人工酶将助力高自由度纳米封装。此外,益生菌与益生元的共封装或成为研究热点。结合关键词演变知识图谱,可以推测该领域未来研究热点,为研究者提供参考。

本文引用格式

黄镇宇 , 徐磊 , 孙培龙 , 杨开 , 蔡铭 , 王舰 . 基于文献计量分析益生菌微胶囊化研究现状及发展趋势[J]. 食品与发酵工业, 2024 , 50(7) : 398 -408 . DOI: 10.13995/j.cnki.11-1802/ts.035924

Abstract

The significance of probiotic products in maintaining intestinal health is continuously being unveiled.However, the physical damage during processing, storage, and transportation, as well as the stresses from gastric acid and bile salts after ingestion, can result in the loss of probiotic viability.To address these issues, the encapsulation of probiotics using microencapsulation technology has emerged as a crucial area of research.Bibliometric tools, including CiteSpace 6.1.R6, VOSviewer 1.6.19, and Bibliometrix were utilized to analyze a total of 1 438 English and Chinese literature sources in this study.The results indicate that research on probiotic microencapsulation is experiencing rapid development, with China leading in the number of publications, showcasing significant potential for future advancements.Encapsulation materials have diversified beyond chitosan and alginate, and spray drying technology has emerged as the most studied method, surpassing freeze-drying.Moreover, the application of diverse bioactive materials, such as polyphenols and artificial enzymes, is becoming increasingly prevalent, enabling high-freedom nano-encapsulation.Additionally, co-encapsulation of probiotics and prebiotics is anticipated to be a prominent research focus.By integrating keyword evolution knowledge mapping, this study offers insights into future research hotspots in the field, thereby guiding researchers in their investigations.

参考文献

[1] BURGAIN J, GAIANI C, LINDER M, et al.Encapsulation of probiotic living cells:From laboratory scale to industrial applications[J].Journal of Food Engineering, 2011, 104(4):467-483.
[2] ANSELMO A C, MCHUGH K J, WEBSTER J, et al.Layer-by-layer encapsulation of probiotics for delivery to the microbiome[J].Advanced Materials, 2016, 28(43):9486-9490.
[3] QUINTANA G, SIMÕES M G, HUGO A, et al.Layer-by-layer encapsulation of Lactobacillus delbrueckii subsp.bulgaricus using block-copolymers of poly(acrylic acid) and pluronic for safe release in gastro-intestinal conditions[J].Journal of Functional Foods, 2017, 35:408-417.
[4] ASSADPOUR E, JAFARI S M.A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers[J].Critical Reviews in Food Science and Nutrition, 2019, 59(19):3129-3151.
[5] CASSANI L, GOMEZ-ZAVAGLIA A, SIMAL-GANDARA J.Technological strategies ensuring the safe arrival of beneficial microorganisms to the gut:From food processing and storage to their passage through the gastrointestinal tract[J].Food Research International, 2020, 129:108852.
[6] 周钰, 刘庆梅, 张军, 等.基于CiteSpace对抗食物过敏研究领域的可视化分析[J].中国食品学报, 2021, 21(6):366-374.
ZHOU Y, LIU Q M, ZHANG J, et al.Visualization analysis of anti food allergy research based on CiteSpace[J].Journal of Chinese Institute of Food Science and Technology, 2021, 21(6):366-374.
[7] REN M N, YU X J, MUJUMDAR A S, et al.Visualizing the knowledge domain of pulsed light technology in the food field:A scientometrics review[J].Innovative Food Science & Emerging Technologies, 2021, 74:102823.
[8] HOU A J, YANG L, LYU J H, et al.A bibliometrics visualization analysis and hotspots prediction for natural product on osteoporosis research from 2000 to 2021[J].Journal of Future Foods, 2022, 2(4):326-337.
[9] 陈悦, 陈超美, 刘则渊, 等.CiteSpace知识图谱的方法论功能[J].科学学研究, 2015, 33(2):242-253.
CHEN Y, CHEN C M, LIU Z Y, et al.The methodology function of CiteSpace mapping knowledge domains[J].Studies in Science of Science, 2015, 33(2):242-253.
[10] 孙人杰, 何琴, 吴德智.基于CiteSpace知识图谱及专利计量对铁皮石斛相关研究的可视化分析[J].食品工业科技, 2023, 44(20):322-330.
SUN R J, HE Q, WU D Z.Visual analysis of Dendrobium candidum related research based on CiteSpace knowledge map and patent bibliometrics[J].Science and Technology of Food Industry, 2023, 44(20):322-330.
[11] 吴雨凌, 马雨辰, 邓胡雪, 等.基于CiteSpace的食品和肠道微生物研究的计量分析[J].食品工业科技, 2022, 43(23):1-10.
WU Y L, MA Y C, DENG H X, et al.Quantitative analysis of food and gut microbiota based on CiteSpace[J].Science and Technology of Food Industry, 2022, 43(23):1-10.
[12] ANAL A K, SINGH H.Recent advances in microencapsulation of probiotics for industrial applications and targeted delivery[J].Trends in Food Science & Technology, 2007, 18(5):240-251.
[13] YAO M F, XIE J J, DU H J, et al.Progress in microencapsulation of probiotics:A review[J].Comprehensive Reviews in Food Science and Food Safety, 2020, 19(2):857-874.
[14] CHÁVARRI M, MARAÑÓN I, ARES R, et al.Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions[J].International Journal of Food Microbiology, 2010, 142(1):185-189.
[15] 钱文文, 辛宝, 任晓梅, 等.CiteSpace联合VOSviewer对血糖生成指数相关文献的可视化分析[J].食品与发酵工业, 2022, 48(18):278-285.
QIAN W W, XIN B, REN X M, et al.Visualization analysis of literatures related to glycemic index based on CiteSpace and VOSviewer[J].Food and Fermentation Industries, 2022, 48(18):278-285.
[16] REQUE P M, BRANDELLI A.Encapsulation of probiotics and nutraceuticals:Applications in functional food industry[J].Trends in Food Science & Technology, 2021, 114:1-10.
[17] DE PRISCO A, MAURIELLO G.Probiotication of foods:A focus on microencapsulation tool[J].Trends in Food Science & Technology, 2016, 48:27-39.
[18] KAVITAKE D, KANDASAMY S, DEVI P B, et al.Recent developments on encapsulation of lactic acid bacteria as potential starter culture in fermented foods:A review[J].Food Bioscience, 2018, 21:34-44.
[19] CHEN W, KONG S, DU L P, et al.Tea polyphenol cytoprotective exoskeleton for living cells[J].Materials Letters, 2021, 293:129670.
[20] KIM J U, KIM B, SHAHBAZ H M, et al. Encapsulation of probiotic Lactobacillus acidophilus by ionic gelation with electrostatic extrusion for enhancement of survival under simulated gastric conditions and during refrigerated storage[J]. International Journal of Food Science & Technology, 2017, 52(2): 519-530.
[21] DING X Q, XU Y B, WANG Y Y, et al.Carboxymethyl konjac glucomannan-chitosan complex nanogels stabilized double emulsions incorporated into alginate hydrogel beads for the encapsulation, protection and delivery of probiotics[J].Carbohydrate Polymers, 2022, 289:119438.
[22] LI Q, LIN H Y, LI J, et al.Improving probiotic (Lactobacillus casei) viability by encapsulation in alginate-based microgels:Impact of polymeric and colloidal fillers[J].Food Hydrocolloids, 2023, 134:108028.
[23] 董阳, 贺佳鑫, 顾悦, 等.高吸附铅乳酸菌的微胶囊化及特性[J].中国食品学报, 2021, 21(3):173-182.
DONG Y, HE J X, GU Y, et al.Microencapsulation and its characteristic of lactic acid bacteria with highly adsorbed ability of lead[J].Journal of Chinese Institute of Food Science and Technology, 2021, 21(3):173-182.
[24] 万茵, 罗成, 张鸿婷, 等.海藻酸钠微胶囊对乳酸菌产乙醛脱氢酶在体外胃肠消化环境中保护作用[J].食品与发酵工业, 2018, 44(9):61-65.
WAN Y, LUO C, ZHANG H T, et al.Protection of Lactobacillus ALDH activity by sodium alginate microcapsule during gastrointestinal digestion in vitro[J].Food and Fermentation Industries, 2018, 44(9):61-65.
[25] SARAO L K, ARORA M.Probiotics, prebiotics, and microencapsulation:A review[J].Critical Reviews in Food Science and Nutrition, 2017, 57(2):344-371.
[26] WŁODARCZYK M, ŚLIŚEWSKA K, BARCZYŃSKA R, et al.Effects of resistant dextrin from potato starch on the growth dynamics of selected co-cultured strains of gastrointestinal bacteria and the activity of fecal enzymes[J].Nutrients, 2022, 14(10):2158.
[27] 李妍, 马蓁.抗性淀粉微胶囊壁材在生物功能活性物质传递系统中应用的研究进展[J].中国粮油学报, 2023, 38(7):238-248.
LI Y, MA Z.Research advances of microcapsule wall materials based on resistant starch in the application of bio-active substance delivery system[J].Journal of the Chinese Cereals and Oils Association, 2023, 38(7):238-248.
[28] CHEN W W, ZHANG T, MA Q, et al.Structure characterization and potential probiotic effects of sorghum and oat resistant dextrins[J].Foods, 2022, 11(13):1877.
[29] OBRADOVIĆ N, VOLIĆ M, NEDOVIĆ V, et al.Microencapsulation of probiotic starter culture in protein-carbohydrate carriers using spray and freeze-drying processes:Implementation in whey-based beverages[J].Journal of Food Engineering, 2022, 321:110948.
[30] VISHALI D A, MONISHA J, SIVAKAMASUNDARI S K, et al.Spray freeze drying:Emerging applications in drug delivery[J].Journal of Controlled Release, 2019, 300:93-101.
[31] SEMYONOV D, RAMON O, KAPLUN Z, et al.Microencapsulation of Lactobacillus paracasei by spray freeze drying[J].Food Research International, 2010, 43(1):193-202.
[32] SOBULSKA M, ZBICINSKI I.Advances in spray drying of sugar-rich products[J].Drying Technology, 2021, 39(12):1774-1799.
[33] SHEEHAN V M, ROSS P, FITZGERALD G F.Assessing the acid tolerance and the technological robustness of probiotic cultures for fortification in fruit juices[J].Innovative Food Science & Emerging Technologies, 2007, 8(2):279-284.
[34] CAMELO-SILVA C, VERRUCK S, AMBROSI A, et al.Innovation and trends in probiotic microencapsulation by emulsification techniques[J].Food Engineering Reviews, 2022, 14(3):462-490.
[35] MA J G, XU C, YU H L, et al.Electro-encapsulation of probiotics in gum Arabic-pullulan blend nanofibres using electrospinning technology[J].Food Hydrocolloids, 2021, 111:106381.
[36] RAMDHAN T, HUNG CHING S, PRAKASH S, et al.Evaluation of alginate-biopolymers (protein, hydrocolloid, starch) composite microgels prepared by the spray aerosol technique as a carrier for green tea polyphenols[J].Food Chemistry, 2022, 371:131382.
[37] COLÍN-CRUZ M A, PIMENTEL-GONZÁLEZ D J, CARRILLO-NAVAS H, et al.Co-encapsulation of bioactive compounds from blackberry juice and probiotic bacteria in biopolymeric matrices[J].LWT, 2019, 110:94-101.
[38] SUN Z Y, HÜBNER R, LI J, et al.Artificially sporulated Escherichia coli cells as a robust cell factory for interfacial biocatalysis[J].Nature Communications, 2022, 13(1):3142.
[39] SU J Q, CAI Y J, TAI K D, et al.High-internal-phase emulsions (HIPEs) for co-encapsulation of probiotics and curcumin:Enhanced survivability and controlled release[J].Food & Function, 2021, 12(1):70-82.
[40] HOSSAIN M N, RANADHEERA C S, FANG Z X, et al.Impact of encapsulating probiotics with cocoa powder on the viability of probiotics during chocolate processing, storage, and in vitro gastrointestinal digestion[J].Journal of Food Science, 2021, 86(5):1629-1641.
[41] CAO F F, JIN L L, GAO Y, et al.Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis[J].Nature Nanotechnology, 2023, 18(6):617-627.
[42] 刘耀东, 贾荣玲, 王国强.益生菌微胶囊化对仔猪生长性能及免疫功能的影响[J].中国饲料, 2021(3):55-59;63.
LIU Y D, JIA R L, WANG G Q.Effect of microencapsulation of probiotics on growth performance and immune function of piglets[J].China Feed, 2021(3):55-59;63.
[43] MISRA S, PANDEY P, MISHRA H N.Novel approaches for co-encapsulation of probiotic bacteria with bioactive compounds, their health benefits and functional food product development:A review[J].Trends in Food Science & Technology, 2021, 109:340-351.
[44] KLEINBERG J.Bursty and hierarchical structure in streams[J].Data Mining and Knowledge Discovery, 2003, 7(4):373-397.
[45] BALTHAZAR C F, GUIMARÃES J F, COUTINHO N M, et al.The future of functional food:Emerging technologies application on prebiotics, probiotics and postbiotics[J].Comprehensive Reviews in Food Science and Food Safety, 2022, 21(3):2560-2586.
[46] LYNCH J P, GOERS L, LESSER C F.Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics[J].Trends in Pharmacological Sciences, 2022, 43(9):772-786.
[47] YAHAV S, BERKOVICH Z, OSTROV I, et al.Encapsulation of beneficial probiotic bacteria in extracellular matrix from biofilm-forming Bacillus subtilis[J].Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46(sup2):974-982.
[48] CHONG L S H, ZHANG J Y, BHAT K S, et al.Bioinspired cell-in-shell systems in biomedical engineering and beyond:Comparative overview and prospects[J].Biomaterials, 2021, 266:120473.
[49] LEE H, KIM N, RHEEM H B, et al.A decade of advances in single-cell nanocoating for mammalian cells[J].Advanced Healthcare Materials, 2021, 10(13):e2100347.
[50] 余帅朋, 崔玥, 王琳, 等.多尺度蛋白质-多糖基益生菌递送体系研究进展[J].食品工业科技, 2023, 44(17):470-482.
YU S P, CUI Y, WANG L, et al.Research advances in the multiscale protein-polysaccharide based systems for probiotics delivery[J].Science and Technology of Food Industry, 2023, 44(17):470-482.
[51] EKANEM E E, ZHANG Z L, VLADISAVLJEVIĆG T.Facile microfluidic production of composite polymer core-shell microcapsules and crescent-shaped microparticles[J].Journal of Colloid and Interface Science, 2017, 498:387-394.
[52] OKURO P K, THOMAZINI M, BALIEIRO J C C, et al.Co-encapsulation of Lactobacillus acidophilus with inulin or polydextrose in solid lipid microparticles provides protection and improves stability[J].Food Research International, 2013, 53(1):96-103.
[53] SILVA M P, TULINI F L, MATOS-JR F E, et al.Application of spray chilling and electrostatic interaction to produce lipid microparticles loaded with probiotics as an alternative to improve resistance under stress conditions[J].Food Hydrocolloids, 2018, 83:109-117.
[54] XU D, LIU Z B, AN Z N, et al.Incorporation of probiotics into 3D printed Pickering emulsion gel stabilized by tea protein/xanthan gum[J].Food Chemistry, 2023, 409:135289.
[55] YUCEL FALCO C, SOTRES J, RASCÓN A, et al.Design of a potentially prebiotic and responsive encapsulation material for probiotic bacteria based on chitosan and sulfated β-glucan[J].Journal of Colloid and Interface Science, 2017, 487:97-106.
[56] MOKHTARI S, JAFARI S M, KHOMEIRI M, et al.The cell wall compound of Saccharomyces cerevisiae as a novel wall material for encapsulation of probiotics[J].Food Research International, 2017, 96:19-26.
文章导航

/