食品与发酵工业 >

2024 , Vol. 50 >Issue 14: 196 - 204

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.036487

研究报告

青熟期托克逊杏咀嚼片对小鼠肠胃功能的影响

  • 王晨 ,
  • 尼格尔热依·亚迪卡尔 ,
  • 冯作山 ,
  • 李硕 ,
  • 杨莲 ,
  • 古丽米热·努尔麦麦提 ,
  • 白羽嘉
展开
  • 1(新疆农业大学 食品科学与药学学院,新疆 乌鲁木齐,830052)
    2(新疆果品采后科学与技术重点实验室,新疆 乌鲁木齐,830052)
第一作者：硕士研究生(尼格尔热依·亚迪卡尔副教授为通信作者,E-mail:nigary-sy@xjau.edu.cn)

收稿日期: 2023-06-15

  修回日期: 2023-08-04

  网络出版日期: 2024-08-02

基金资助

新疆杏产业技术体系专项资金项目(XJCYTX-03-05-2021);新疆农业大学研究生科研创新计划项目(XJAUGRI2023047)

收起

Effects of green ripe period Tuokexun apricot chewable tablets on gastrointestinal function in mice

  • WANG Chen ,
  • NIGARY·Yadikar ,
  • FENG Zuoshan ,
  • LI Shuo ,
  • YANG Lian ,
  • GULIMIRE·Nuermaimaiti ,
  • BAI Yujia
Expand
  • 1(School of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi 830052, China)
    2(Xinjiang Key Laboratory of Science and Technology, Urumqi 830052, China)

Received date: 2023-06-15

  Revised date: 2023-08-04

  Online published: 2024-08-02

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摘要

该文旨在研究自制青熟期托克逊杏咀嚼片对小鼠肠胃功能的影响。将昆明小鼠自由组合分为空白对照组、阳性对照组、模型对照组、青熟期托克逊杏果实组、青熟期托克逊杏咀嚼片低剂量组、青熟期托克逊杏咀嚼片中剂量组、青熟期托克逊杏咀嚼片高剂量组。经适应性喂养7 d后,采用盐酸洛哌丁胺对小鼠造便秘模型,通过对小鼠肠胃功能的研究,得到小鼠排首粒蓝便时间、6 h内排便粒数、粪便含水率、小肠推进率、结肠含水率、胃排空率的影响。结果表明,青熟期托克逊杏咀嚼片(低、中、高)剂量组与便秘模型对照组、阳性对照组、青熟期托克逊杏果实组相比较,各项指标均有不同的显著差异。结论表明青熟期托克逊杏咀嚼片能明显提高便秘模型小鼠的小肠推进率,缩短小鼠排便时间、增加6 h排便粒数、增加胃排空率、提高粪便含水率和结肠含水率,并深入研究了其通便作用机制,表明青熟期托克逊杏咀嚼片可调节P物质、血管活性肠肽含量,促进肠道蠕动,改善便秘的情况。

关键词： 青熟期托克逊杏; 咀嚼片; 润肠通便; 便秘; 小鼠

本文引用格式

王晨 , 尼格尔热依·亚迪卡尔 , 冯作山 , 李硕 , 杨莲 , 古丽米热·努尔麦麦提 , 白羽嘉 . 青熟期托克逊杏咀嚼片对小鼠肠胃功能的影响[J]. 食品与发酵工业, 2024 , 50(14) : 196 -204 . DOI: 10.13995/j.cnki.11-1802/ts.036487

Abstract

This study aimed to investigate the effect of homemade green ripe period chewing tablets on gastrointestinal function in mice.The free combination of Kunming mice was divided into a blank control group, a positive control group, a model control group, a green ripe period Tuokexun apricot fruit group, a low-dose group of green ripe period Tuokexun apricot chewable tablets, a medium dose group of green ripe period Tuokexun apricot chewable tablets, and a high-dose group of green ripe period Tuokexun apricot chewable tablets.After 7 days of adaptive feeding, loperamide hydrochloride was used in the mouse model of constipation, through studies of gastrointestinal function in mice, the effects of first blue stool time, the number of defecation grains, fecal moisture content, small bowel propulsion rate, colon water content, and gastric emptying rate were obtained.Results showed that there were significant differences in various indicators between the low, medium, and high dose groups of the green ripening stage Tuokexun apricot chewing tablets and the constipation model control group, positive control group, and green ripening stage Tuokexun apricot fruit group.This indicated that the green ripe period Tuokexun apricot chewing tablets could significantly improve the small intestine propulsion rate, shorten the defecation time, increase the number of defecated particles in 6 hours, increase gastric emptying rate, fecal water content, and colon water content in constipation model mice, through deeply studying the laxative mechanism, showing that it could regulate the content of P substance and vasoactive intestinal peptide, promote intestinal peristalsis, and improve constipation.

Key words： green ripe period Tuokexun; chewable tablet; relaxing bowel; constipation; mice

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