[1] KIM R, SUNG J H.Recent advances in gut- and gut-organ-axis-on-a-chip models [J].Advanced Healthcare Materials, 2024,13(21):e23032777.
[2] MCCOY R, OLDROYD S, YANG W, et al.In vitro models for investigating intestinal host-pathogen interactions[J].Advanced Science, 2024, 11(8):2306727.
[3] STEINWAY S N, SALEH J, KOO B K, et al.Human microphysiological models of intestinal tissue and gut microbiome [J].Frontiers in Bioengineering and Biotechnology, 2020, 8:725.
[4] MALIJAUSKAITE S, CONNOLLY S, NEWPORT D, et al.Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms [J].Cytokine & Growth Factor Reviews, 2021, 60:76-88.
[5] TORRAS N, ZABALO J, ABRIL E, et al.A bioprinted 3D gut model with crypt-villus structures to mimic the intestinal epithelial-stromal microenvironment [J].Biomaterials Advances, 2023, 153:213534.
[6] ZACHOS N C, KOVBASNJUK O, FOULKE-ABEL J, et al.Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology [J].Journal of Biological Chemistry, 2016, 291(8):3759-3766.
[7] GAO J W, CAO B, ZHAO R Y, et al.Critical signaling transduction pathways and intestinal barrier:Implications for pathophysiology and therapeutics [J].Pharmaceuticals, 2023, 16(9):1216.
[8] GROOTJANS J, THUIJLS G, VERDAM F, et al.Non-invasive assessment of barrier integrity and function of the human gut [J].World Journal of Gastrointestinal Surgery, 2010, 2(3):61-69.
[9] MÉNARD S, LACROIX-LAMANDÉ S, EHRHARDT K, et al.Cross-talk between the intestinal epithelium and Salmonella typhimurium [J].Frontiers in Microbiology, 2022, 13:906238.
[10] ALLAM-NDOUL B, CASTONGUAY-PARADIS S, VEILLEUX A.Gut microbiota and intestinal trans-epithelial permeability [J].International Journal of Molecular Sciences, 2020, 21(17):6402.
[11] VONAESCH P, ANDERSON M, SANSONETTI P J.Pathogens, microbiome and the host:Emergence of the ecological Koch’s postulates [J].FEMS Microbiology Reviews, 2018, 42(3):273-292.
[12] MIRZAEI R, DEHKHODAIE E, BOUZARI B, et al.Dual role of microbiota-derived short-chain fatty acids on host and pathogen [J].Biomedicine & Pharmacotherapy, 2022, 145:112352.
[13] ABT M C, PAMER E G.Commensal bacteria mediated defenses against pathogens [J].Current Opinion in Immunology, 2014, 29:16-22.
[14] GARCÍA-DÍAZ M, CENDRA M D M, ALONSO-ROMAN R, et al.Mimicking the intestinal host-pathogen interactions in a 3D in vitro model:The role of the mucus layer [J].Pharmaceutics, 2022, 14(8):1552.
[15] SANTOS R L.Pathobiology of Salmonella, intestinal microbiota, and the host innate immune response [J].Frontiers in Immunology, 2014, 5:252.
[16] MOSSER D M, EDWARDS J P.Exploring the full spectrum of macrophage activation [J].Nature Reviews Immunology, 2008, 8(12):958-969.
[17] SAEZ A, HERRERO-FERNANDEZ B, GOMEZ-BRIS R, et al.Pathophysiology of inflammatory bowel disease:Innate immune system [J].International Journal of Molecular Sciences, 2023, 24(2):1526.
[18] GUERREIRO D N, ARCARI T, O’BYRNE C P.The σB-mediated general stress response of Listeria monocytogenes:Life and death decision making in a pathogen [J].Frontiers in Microbiology, 2020, 11:1505.
[19] GAHAN C G M, HILL C.Listeria monocytogenes:Survival and adaptation in the gastrointestinal tract [J].Frontiers in Cellular and Infection Microbiology, 2014, 4:9.
[20] QUEREDA J J, DUSSURGET O, NAHORI M A, et al.Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection [J].Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(20):5706-5711.
[21] QUEREDA J J, MORÓN-GARCÍA A, PALACIOS-GORBA C, et al.Pathogenicity and virulence of Listeria monocytogenes:A trip from environmental to medical microbiology [J].Virulence, 2021, 12(1):2509-2545.
[22] LIU B, JIANG L Y, LIU Y T, et al.Enterohaemorrhagic E.coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization [J].Nature Communications, 2023, 14(1):7227.
[23] GARMENDIA J, FRANKEL G, CREPIN V F.Enteropathogenic and enterohemorrhagic Escherichia coli infections:Translocation, translocation, translocation [J].Infection and Immunity, 2005, 73(5):2573-2585.
[24] LANGE M E, UWIERA R R E, DOUGLAS INGLIS G.Enteric Escherichia coli O157:H7 in cattle, and the use of mice as a model to elucidate key aspects of the host-pathogen-microbiota interaction:A review [J].Frontiers in Veterinary Science, 2022, 9:937866.
[25] JAJERE S M.A review of Salmonella enterica with particular focus on the pathogenicity and virulence factors, host specificity and antimicrobial resistance including multidrug resistance [J].Veterinary World, 2019, 12(4):504-521.
[26] YIN Y B, ZHOU D G.Organoid and enteroid modeling of Salmonella infection [J].Frontiers in Cellular and Infection Microbiology, 2018, 8:102.
[27] BAKOWSKI M A, BRAUN V, BRUMELL J H.Salmonella-containing vacuoles:Directing traffic and nesting to grow[J].Traffic, 2008, 9(12):2022-2031.
[28] KIM J B.Three-dimensional tissue culture models in cancer biology [J].Seminars in Cancer Biology, 2005, 15(5):365-377.
[29] CHAICHAROENAUDOMRUNG N, KUNHORM P, NOISA P.Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling [J].World Journal of Stem Cells, 2019, 11(12):1065-1083.
[30] CHIEW G G Y, WEI N, SULTANIA S, et al.Bioengineered three-dimensional co-culture of cancer cells and endothelial cells:A model system for dual analysis of tumor growth and angiogenesis [J].Biotechnology and Bioengineering, 2017, 114(8):1865-1877.
[31] LIN R Z, CHANG H Y.Recent advances in three-dimensional multicellular spheroid culture for biomedical research [J].Biotechnology Journal, 2008, 3(9-10):1172-1184.
[32] NETO A I, CORREIA C R, OLIVEIRA M B, et al.A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening [J].Biomaterials Science, 2015, 3(4):581-585.
[33] CUI X, HARTANTO Y, ZHANG H.Advances in multicellular spheroids formation [J].Journal of the Royal Society Interface, 2017, 14(127):20160877.
[34] CUI X, DINI S, DAI S, et al.A mechanistic study on tumour spheroid formation in thermosensitive hydrogels:Experiments and mathematical modelling [J].RSC Advances, 2016, 6(77):73282-73291.
[35] BIAŁKOWSKA K, KOMOROWSKI P, BRYSZEWSKA M, et al.Spheroids as a type of three-dimensional cell cultures-examples of methods of preparation and the most important application [J].International Journal of Molecular Sciences, 2020, 21(17):6225.
[36] NICKERSON C A, GOODWIN T J, TERLONGE J, et al.Three-dimensional tissue assemblies:Novel models for the study of Salmonella enterica serovar typhimurium pathogenesis [J].Infection and Immunity, 2001, 69(11):7106-7120.
[37] BARRILA J, YANG J, CRABBÉ A, et al.Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns [J].NPJ Microgravity, 2017, 3:10.
[38] DE WEIRDT R, CRABBÉ A, ROOS S, et al.Glycerol supplementation enhances L.reuteri′s protective effect against S.typhimurium colonization in a 3-D model of colonic epithelium [J].PLoS One, 2012, 7(5):e37116.
[39] 宋仪洋,吴梦洁,董庆利,等.食源性致病菌感染体内外肠道模型研究进展[J].食品与发酵工业,2024,50(5):340-349.
SONG Y Y, WU M J, DONG Q L, etc.Research progress on in vivo and external intestinal models of foodborne pathogenic bacteria infection[J].Food and Fermentation Industries,2024,50(5):340-349.
[40] CHUSILP S, LI B, LEE D, et al.Intestinal organoids in infants and children [J].Pediatric Surgery International, 2020, 36(1):1-10.
[41] SATO T, VRIES R G, SNIPPERT H J, et al.Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche [J].Nature, 2009, 459(7244):262-265.
[42] SPENCE J R, MAYHEW C N, RANKIN S A, et al.Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro [J].Nature, 2011, 470(7332):105-109.
[43] ZHANG Y G, WU S P, XIA Y L, et al.Salmonella-infected crypt-derived intestinal organoid culture system for host-bacterial interactions [J].Physiological Reports, 2014, 2(9):e12147.
[44] HUANG J, ZHOU C, ZHOU G H, et al.Effect of Listeria monocytogenes on intestinal stem cells in the co-culture model of small intestinal organoids [J].Microbial Pathogenesis, 2021, 153:104776.
[45] ROUCH J D, SCOTT A, LEI N Y, et al.Development of functional microfold (M) cells from intestinal stem cells in primary human enteroids [J].PLoS One, 2016, 11(1):e0148216.
[46] PRADHAN S, WEISS A A.Probiotic properties of Escherichia coli nissle in human intestinal organoids [J].mBio, 2020, 11(4):e01470-20.
[47] LU X X, XIE S, YE L L, et al.Lactobacillus protects against S.typhimurium-induced intestinal inflammation by determining the fate of epithelial proliferation and differentiation [J].Molecular Nutrition & Food Research, 2020, 64(5):e1900655.
[48] CO J Y, MARGALEF-CATALÀ M, LI X N, et al.Controlling epithelial polarity:A human enteroid model for host-pathogen interactions [J].Cell Reports, 2019, 26(9):2509-2520.e4
[49] 李向阳, 史鹏程, 张乐, 等.肠芯片在宿主-微生物互作中的研究进展 [J].生物工程学报, 2024,40(9):2916-2933.
LI X Y, SHI P C, ZHANG L, et al.Research progress of intestinal chip in host-microbe interaction [J].Chinese Journal of Biotechnology, 2024,40(9):2916-2933.
[50] SHIN W, HINOJOSA C D, INGBER D E, et al.Human intestinal morphogenesis controlled by transepithelial morphogen gradient and flow-dependent physical cues in a microengineered gut-on-a-chip [J].IScience, 2019, 15:391-406.
[51] TRIETSCH S J, NAUMOVSKA E, KUREK D, et al.Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes [J].Nature Communications, 2017, 8(1):262.
[52] NIKOLAEV M, MITROFANOVA O, BROGUIERE N, et al.Homeostatic mini-intestines through scaffold-guided organoid morphogenesis [J].Nature, 2020, 585(7826):574-578.
[53] KASENDRA M, LUC R, YIN J Y, et al.Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model [J].eLife, 2020, 9:e50135.
[54] ZHANG D X, QIAO L.Intestine-on-a-chip for intestinal disease study and pharmacological research [J].View, 2023, 4(1):20220037.
[55] BEAURIVAGE C, NAUMOVSKA E, CHANG Y X, et al.Development of a gut-on-a-chip model for high throughput disease modeling and drug discovery [J].International Journal of Molecular Sciences, 2019, 20(22):5661.
[56] LIANG D, SU W T, TAN M Q.Advances of microfluidic intestine-on-a-chip for analyzing anti-inflammation of food [J].Critical Reviews in Food Science and Nutrition, 2022, 62(16):4418-4434.
[57] COSTELLO C M, SORNA R M, GOH Y L, et al.3-D intestinal scaffolds for evaluating the therapeutic potential of probiotics [J].Molecular Pharmaceutics, 2014, 11(7):2030-2039.
[58] LIU H T, WANG Y Q, CUI K L, et al.Advances in hydrogels in organoids and organs-on-a-chip [J].Advanced Materials, 2019, 31(50):e1902042.
[59] GRASSART A, MALARDÉ V, GOBAA S, et al.Bioengineered human organ-on-chip reveals intestinal microenvironment and mechanical forces impacting Shigella infection[J].Cell Host & Microbe, 2019, 26(3):435-444.e4
[60] CHIN W H, KETT C, COOPER O, et al.Bacteriophages evolve enhanced persistence to a mucosal surface [J].Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(27):e2116197119.
[61] JEON M S, CHOI Y Y, MO S J, et al.Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip [J].Nano Convergence, 2022, 9(1):8.
[62] KASENDRA M, TOVAGLIERI A, SONTHEIMER-PHELPS A, et al.Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids [J].Scientific Reports, 2018, 8(1):2871.
[63] SUNUWAR L, YIN J Y, KASENDRA M, et al.Mechanical stimuli affect Escherichia coli heat-stable enterotoxin-cyclic GMP signaling in a human enteroid intestine-chip model [J].Infection and Immunity, 2020, 88(3):e00866-19.
[64] GAZZANIGA F S, CAMACHO D M, WU M, et al.Harnessing colon chip technology to identify commensal bacteria that promote host tolerance to infection [J].Frontiers in Cellular and Infection Microbiology, 2021, 11:638014.
[65] KIM H J, LI H, COLLINS J J, et al.Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip [J].Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(1):E7-15.
[66] JING B L, WANG Z A, ZHANG C, et al.Establishment and application of peristaltic human gut-vessel microsystem for studying host-microbial interaction [J].Frontiers in Bioengineering and Biotechnology, 2020, 8:272.
[67] ROGAL J, PROBST C, LOSKILL P.Integration concepts for multi-organ chips:How to maintain flexibility?! [J].Future Science OA, 2017, 3(2):FSO180.
[68] BRICKS T, PAULLIER P, LEGENDRE A, et al.Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines [J].Toxicology in Vitro, 2014, 28(5):885-895.
[69] MASCHMEYER I, LORENZ A K, SCHIMEK K, et al.A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [J].Lab on a Chip, 2015, 15(12):2688-2699.
[70] LEE Y, KIM M H, ALVES D R, et al.Gut-kidney axis on chip for studying effects of antibiotics on risk of hemolytic uremic syndrome by shiga toxin-producing Escherichia coli [J].Toxins, 2021, 13(11):775.
[71] JIE M S, LIN H F, HE Z Y, et al.An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation [J].Science China-Chemistry, 2018, 61(2):236-242.
[72] MOTA C, CAMARERO-ESPINOSA S, BAKER M B, et al.Bioprinting:From tissue and organ development to in vitro models [J].Chemical Reviews, 2020, 120(19):10 547-10 607.
[73] OZBOLAT I T.Bioprinting scale-up tissue and organ constructs for transplantation [J].Trends in Biotechnology, 2015, 33(7):395-400.
[74] HEINRICH M A, LIU W J, JIMENEZ A, et al.3D bioprinting:From benches to translational applications [J].Small, 2019, 15(23):e1805510.
[75] MANDRYCKY C, WANG Z J, KIM K, et al.3D bioprinting for engineering complex tissues [J].Biotechnology Advances, 2016, 34(4):422-434.
[76] CRIS WILSON W Jr, BOLAND T.Cell and organ printing 1:Protein and cell printers [J].The Anatomical. Record Part A,Discoveries in Molecular, Cellular, and Evolutionary Biology, 2003, 272(2):491-496.
[77] DUOCASTELLA M, COLINA M, FERNÀNDEZ-PRADAS J M, et al.Study of the laser-induced forward transfer of liquids for laser bioprinting [J].Applied Surface Science, 2007, 253(19):7855-7859.
[78] MADDEN L R, NGUYEN T V, GARCIA-MOJICA S, et al.Bioprinted 3D primary human intestinal tissues model aspects of native physiology and ADME/tox functions [J].iScience, 2018, 2:156-167.
[79] KIM W, KIM G.Intestinal villi model with blood capillaries fabricated using collagen-based bioink and dual-cell-printing process[J].ACS Applied Materials & Interfaces, 2018, 10(48):41185-41196.